Two new diterpenoids, maoecrystal U and epi-maoecrystal P were isolated from the leaves of Isodon eriocalyx. Their structures were determined as 6 beta-acetoxy-15 beta-hydroxy-3 alpha, 20epoxy-ent-kaur-16-ene-1,7-dion...Two new diterpenoids, maoecrystal U and epi-maoecrystal P were isolated from the leaves of Isodon eriocalyx. Their structures were determined as 6 beta-acetoxy-15 beta-hydroxy-3 alpha, 20epoxy-ent-kaur-16-ene-1,7-dione 1 and 16 (s)-methoxymethyl-6 beta,7 beta-dihydroxy-7 alpha,20-epoxy-ent-kaur-2,3-ethenylene-1, 15-dione 2 respectively, by spectroscopic methods.展开更多
Two new ent-kaurenoids, 19-acetyl-ent-3β, 17-dihydroxykaur-15-ene (1), 19-acetyl-ent- 3β-hydroxykaur-15-en-17-al (2) were isolated from Cacalia pilgeriana. Their structures were elucidated by spectroscopic methods.
Three new ent-kaurene diterpenoids, adenanthins N, 0 and P (1-3), and four known diterpenoids, leucophyllin E (4), glabcensin C (5), adenanthin A (6), leucophyllin B (7), together with a highly unsaturated fatty acid,...Three new ent-kaurene diterpenoids, adenanthins N, 0 and P (1-3), and four known diterpenoids, leucophyllin E (4), glabcensin C (5), adenanthin A (6), leucophyllin B (7), together with a highly unsaturated fatty acid, 9,16-dioxo-10,1 2,14-octadeca-trienoic acid (8), were isolated from Isodon adenanthus (Diels) Kudo. The structure of compound 4 was revised accordingly. Compound I showed significant cytotoxic activity against K562 cells with IC50 = 0.45 mug/mL.展开更多
Three crystalline components, a new kaurane type diterpenoid named macrocalyxin H and two known diterpenoid oridonin and enmenol, were isolated from the leaves of Rabdosia macrocalyx (Dunn) Hara.Based on IR, MS, 1 H 1...Three crystalline components, a new kaurane type diterpenoid named macrocalyxin H and two known diterpenoid oridonin and enmenol, were isolated from the leaves of Rabdosia macrocalyx (Dunn) Hara.Based on IR, MS, 1 H 1H COSY, 13 C 1H COSY and NOE spectroscopy, the structure of macrocalyxin H was determined as ent 7β 20 epoxy 1α, 6α, 7α, 15α, 16α pentahydroxy kaurene 17 acetate.展开更多
Known diterpenoid maoyerabdosin was isolated from the leaves of Rabdosia macrocalyx (Dunn) Hara.Based on elemental analyses and spectra of MS,NMR,COSY and NOESY,the structure of maoyerabdosin was revised as ent 7β 20...Known diterpenoid maoyerabdosin was isolated from the leaves of Rabdosia macrocalyx (Dunn) Hara.Based on elemental analyses and spectra of MS,NMR,COSY and NOESY,the structure of maoyerabdosin was revised as ent 7β 20 epoxy 1α,7α,15α,16α tetrahydro xy kaurene 6α,17 diacetate.展开更多
文摘Two new diterpenoids, maoecrystal U and epi-maoecrystal P were isolated from the leaves of Isodon eriocalyx. Their structures were determined as 6 beta-acetoxy-15 beta-hydroxy-3 alpha, 20epoxy-ent-kaur-16-ene-1,7-dione 1 and 16 (s)-methoxymethyl-6 beta,7 beta-dihydroxy-7 alpha,20-epoxy-ent-kaur-2,3-ethenylene-1, 15-dione 2 respectively, by spectroscopic methods.
基金This work was supported by the NNSFC(No．29972017 and No．20021001一QT Program)
文摘Two new ent-kaurenoids, 19-acetyl-ent-3β, 17-dihydroxykaur-15-ene (1), 19-acetyl-ent- 3β-hydroxykaur-15-en-17-al (2) were isolated from Cacalia pilgeriana. Their structures were elucidated by spectroscopic methods.
文摘Three new ent-kaurene diterpenoids, adenanthins N, 0 and P (1-3), and four known diterpenoids, leucophyllin E (4), glabcensin C (5), adenanthin A (6), leucophyllin B (7), together with a highly unsaturated fatty acid, 9,16-dioxo-10,1 2,14-octadeca-trienoic acid (8), were isolated from Isodon adenanthus (Diels) Kudo. The structure of compound 4 was revised accordingly. Compound I showed significant cytotoxic activity against K562 cells with IC50 = 0.45 mug/mL.
文摘Three crystalline components, a new kaurane type diterpenoid named macrocalyxin H and two known diterpenoid oridonin and enmenol, were isolated from the leaves of Rabdosia macrocalyx (Dunn) Hara.Based on IR, MS, 1 H 1H COSY, 13 C 1H COSY and NOE spectroscopy, the structure of macrocalyxin H was determined as ent 7β 20 epoxy 1α, 6α, 7α, 15α, 16α pentahydroxy kaurene 17 acetate.
文摘Known diterpenoid maoyerabdosin was isolated from the leaves of Rabdosia macrocalyx (Dunn) Hara.Based on elemental analyses and spectra of MS,NMR,COSY and NOESY,the structure of maoyerabdosin was revised as ent 7β 20 epoxy 1α,7α,15α,16α tetrahydro xy kaurene 6α,17 diacetate.
