【目的】观察氟伐他汀联合缬沙坦治疗糖尿病肾病（DN）患者的临床疗效及对内皮素-1（ET-1）和降钙素基因相关肽（CGRP）的影响。【方法】将70例DN患者随机分为观察组和对照组，每组35例；在常规治疗的基础上，观察组给予氟伐他汀联合缬...【目的】观察氟伐他汀联合缬沙坦治疗糖尿病肾病（DN）患者的临床疗效及对内皮素-1（ET-1）和降钙素基因相关肽（CGRP）的影响。【方法】将70例DN患者随机分为观察组和对照组，每组35例；在常规治疗的基础上，观察组给予氟伐他汀联合缬沙坦治疗，对照组给予缬沙坦治疗；3个月后分析比较两组患者的24 h尿蛋白定量和血中ET-1、CGRP水平、临床总有效率及不良反应发生情况。【结果】两组患者的24 h尿蛋白定量和血中ET-1水平均较治疗前降低，血中CGRP水平均较治疗前升高，差异有统计学意义（ P ＜0．05或 P ＜0．01），且上述指标的改善观察组优于对照组（ P ＜0．05）；观察组的临床总有效率为91．43％，优于对照组的74．29％（ P ＜0．05）；两组不良反应发生率比较差异无统计学意义（ P ＞0．05）。【结论】氟伐他汀联合缬沙坦治疗DN安全有效，其降脂降压外的肾保护作用可能与调节血中ET-1、CGRP水平有关。展开更多
Objective We have reported previously that ceruleininduced edematous pancreatitis would transform into hemorrhagic pancreatitis by administration of endothelin1 in rats In the present study, we tried to protect rat ...Objective We have reported previously that ceruleininduced edematous pancreatitis would transform into hemorrhagic pancreatitis by administration of endothelin1 in rats In the present study, we tried to protect rat model from developing into hemorrhagic pancreatitis with BQ123 (an ETA receptor ant agonist) Methods The rat model was made by 5hour restraint waterimmersion st ress and two intraperitoneal injections of cerulein (40?g/kg) at hourly inter val BQ123 (3 or 6?mg/kg) was administered intravenously 30 minutes befo re and 2 hours after the first cerulein injection Results Acute hemorrhagic pancreatitis was induced in all rats treated with cerulin+stress The score for pancreatic hemorrhage was 2402 in this g roup In the rats pretreated with BQ123, the score was reduced to 100 0, p ancreas wet weight and serum amylase activity were significantly reduced, and hi stologic alterations in the pancreas lightened, also the local pancreatic blood flow improved without affecting the systemic blood pressure Conclusions These results suggest that endothelin1 should play a role in aggravating the development of acute hemorrhagic pancreatitis, through its a ction on the pancreatic microcirculation展开更多
文摘【目的】观察氟伐他汀联合缬沙坦治疗糖尿病肾病（DN）患者的临床疗效及对内皮素-1（ET-1）和降钙素基因相关肽（CGRP）的影响。【方法】将70例DN患者随机分为观察组和对照组，每组35例；在常规治疗的基础上，观察组给予氟伐他汀联合缬沙坦治疗，对照组给予缬沙坦治疗；3个月后分析比较两组患者的24 h尿蛋白定量和血中ET-1、CGRP水平、临床总有效率及不良反应发生情况。【结果】两组患者的24 h尿蛋白定量和血中ET-1水平均较治疗前降低，血中CGRP水平均较治疗前升高，差异有统计学意义（ P ＜0．05或 P ＜0．01），且上述指标的改善观察组优于对照组（ P ＜0．05）；观察组的临床总有效率为91．43％，优于对照组的74．29％（ P ＜0．05）；两组不良反应发生率比较差异无统计学意义（ P ＞0．05）。【结论】氟伐他汀联合缬沙坦治疗DN安全有效，其降脂降压外的肾保护作用可能与调节血中ET-1、CGRP水平有关。
文摘Objective We have reported previously that ceruleininduced edematous pancreatitis would transform into hemorrhagic pancreatitis by administration of endothelin1 in rats In the present study, we tried to protect rat model from developing into hemorrhagic pancreatitis with BQ123 (an ETA receptor ant agonist) Methods The rat model was made by 5hour restraint waterimmersion st ress and two intraperitoneal injections of cerulein (40?g/kg) at hourly inter val BQ123 (3 or 6?mg/kg) was administered intravenously 30 minutes befo re and 2 hours after the first cerulein injection Results Acute hemorrhagic pancreatitis was induced in all rats treated with cerulin+stress The score for pancreatic hemorrhage was 2402 in this g roup In the rats pretreated with BQ123, the score was reduced to 100 0, p ancreas wet weight and serum amylase activity were significantly reduced, and hi stologic alterations in the pancreas lightened, also the local pancreatic blood flow improved without affecting the systemic blood pressure Conclusions These results suggest that endothelin1 should play a role in aggravating the development of acute hemorrhagic pancreatitis, through its a ction on the pancreatic microcirculation
