AFDX(Avionics Full Duplex Switch Ethernet)是空客公司首先提出的,并在A380上应用的一种新型机载通信网络,具有高可靠、强实时和高安全性的优点。在应用商业以太网技术的基础上,通过增加特殊功能来保证航空应用的确定性和可靠性。在...AFDX(Avionics Full Duplex Switch Ethernet)是空客公司首先提出的,并在A380上应用的一种新型机载通信网络,具有高可靠、强实时和高安全性的优点。在应用商业以太网技术的基础上,通过增加特殊功能来保证航空应用的确定性和可靠性。在解析协议的基础上,介绍AFDX网络的关键技术,并针对AFDX网络测试的需求,提出了一种基于FPGA的AFDX监控测试卡技术方案,并对板卡设计中的系统结构、功能组成,以及关键模块的设计进行了较详细的介绍。试验结果表明该测试卡可满足端系统和交换机的测试以及网络监控需求,并为以后相关测试系统的研制提供了设计思路和借鉴经验。展开更多
Non-alcoholic fatty liver disease(NAFLD)is a major cause of liver disease around the world.It includes a spectrum of conditions from simple steatosis to non-alcoholic steatohepatitis(NASH)and can lead to fibrosis,cirr...Non-alcoholic fatty liver disease(NAFLD)is a major cause of liver disease around the world.It includes a spectrum of conditions from simple steatosis to non-alcoholic steatohepatitis(NASH)and can lead to fibrosis,cirrhosis,liver failure,and/or hepatocellular carcinoma.NAFLD is also associated with other medical conditions such as obesity,diabetes mellitus(DM),metabolic syn-drome,hypertension,insulin resistance,hyperlipidemia,and cardiovascular disease(CVD).In diabetes,chronic hyperglycemia contributes to the development of both macro-and microvascular conditions through a variety of metabolic pathways.Thus,it can cause a variety of metabolic and hemodynamic conditions,including upregulated advanced glycation end-products(AGEs)synthesis.In our previous study,the most abundant type of toxic AGEs(TAGE);i.e.,glyceraldehyde-derived AGEs,were found to make a significant contribution to the pathogenesis of DM-induced angiopathy.Furthermore,accumulating evidence suggests that the binding of TAGE with their receptor(RAGE)induces oxidative damage,promotes inflammation,and causes changes in intracellular signaling and the expression levels of certain genes in various cell populations including hepatocytes and hepatic stellate cells.All of these effects could facilitate the pathogenesis of hypertension,cancer,diabetic vascular complications,CVD,dementia,and NASH.Thus,inhibiting TAGE synthesis,preventing TAGE from binding to RAGE,and downregulating RAGE expression and/or the expression of associated effector molecules all have potential as therapeutic strategies against NASH.Here,we examine the contributions of RAGE and TAGE to various conditions and novel treatments that target them in order to prevent the development and/or progression of NASH.展开更多
In order to improve robotic harvesting and reduce production cost,a harvesting robot system for strawberry on the elevated-trough culture was designed.It was supposed to serve for sightseeing agriculture and technolog...In order to improve robotic harvesting and reduce production cost,a harvesting robot system for strawberry on the elevated-trough culture was designed.It was supposed to serve for sightseeing agriculture and technological education.Based on the sonar-camera sensor,an autonomous navigation system of the harvesting robot was built to move along the trough lines independently.The mature fruits were recognized according to the H(Hue)and S(Saturation)color feature and the picking-point were located by the binocular-vision unit.A nondestructive end-effector,used to suck the fruit,hold and cut the fruit-stem,was designed to prevent pericarp damage and disease infection.A joint-type industrial manipulator with six degrees-of-freedom(DOF)was utilized to carry the end-effector.The key points and time steps for the collision-free and rapid motion of manipulator were planned.Experimental results showed that all the 100 mature strawberry targets were recognized automatically in the harvesting test.The success harvesting rate was 86%,and the success harvesting operation cost 31.3 seconds on average,including a single harvest operation of 10 seconds.The average error for fruit location was less than 4.6 mm.展开更多
文摘AFDX(Avionics Full Duplex Switch Ethernet)是空客公司首先提出的,并在A380上应用的一种新型机载通信网络,具有高可靠、强实时和高安全性的优点。在应用商业以太网技术的基础上,通过增加特殊功能来保证航空应用的确定性和可靠性。在解析协议的基础上,介绍AFDX网络的关键技术,并针对AFDX网络测试的需求,提出了一种基于FPGA的AFDX监控测试卡技术方案,并对板卡设计中的系统结构、功能组成,以及关键模块的设计进行了较详细的介绍。试验结果表明该测试卡可满足端系统和交换机的测试以及网络监控需求,并为以后相关测试系统的研制提供了设计思路和借鉴经验。
基金Supported by The Japan Society for the Promotion of Science(JSPS)KAKENHI Grant,No.19300254,22300264 and 25282029(Takeuchi M)Kanazawa Medical University,No.SR2012-04(Tsutsumi M)the Ministry of Education,Culture,Sports,Science,and Technology(MEXT),Regional Innovation Strategy Support Program(Takeuchi M)
文摘Non-alcoholic fatty liver disease(NAFLD)is a major cause of liver disease around the world.It includes a spectrum of conditions from simple steatosis to non-alcoholic steatohepatitis(NASH)and can lead to fibrosis,cirrhosis,liver failure,and/or hepatocellular carcinoma.NAFLD is also associated with other medical conditions such as obesity,diabetes mellitus(DM),metabolic syn-drome,hypertension,insulin resistance,hyperlipidemia,and cardiovascular disease(CVD).In diabetes,chronic hyperglycemia contributes to the development of both macro-and microvascular conditions through a variety of metabolic pathways.Thus,it can cause a variety of metabolic and hemodynamic conditions,including upregulated advanced glycation end-products(AGEs)synthesis.In our previous study,the most abundant type of toxic AGEs(TAGE);i.e.,glyceraldehyde-derived AGEs,were found to make a significant contribution to the pathogenesis of DM-induced angiopathy.Furthermore,accumulating evidence suggests that the binding of TAGE with their receptor(RAGE)induces oxidative damage,promotes inflammation,and causes changes in intracellular signaling and the expression levels of certain genes in various cell populations including hepatocytes and hepatic stellate cells.All of these effects could facilitate the pathogenesis of hypertension,cancer,diabetic vascular complications,CVD,dementia,and NASH.Thus,inhibiting TAGE synthesis,preventing TAGE from binding to RAGE,and downregulating RAGE expression and/or the expression of associated effector molecules all have potential as therapeutic strategies against NASH.Here,we examine the contributions of RAGE and TAGE to various conditions and novel treatments that target them in order to prevent the development and/or progression of NASH.
基金Funding for this research was provided by the National High Technology Research and Development Program of China(2012AA101903)the National Science&Technology Pillar Program of China(2012BAF07B02).
文摘In order to improve robotic harvesting and reduce production cost,a harvesting robot system for strawberry on the elevated-trough culture was designed.It was supposed to serve for sightseeing agriculture and technological education.Based on the sonar-camera sensor,an autonomous navigation system of the harvesting robot was built to move along the trough lines independently.The mature fruits were recognized according to the H(Hue)and S(Saturation)color feature and the picking-point were located by the binocular-vision unit.A nondestructive end-effector,used to suck the fruit,hold and cut the fruit-stem,was designed to prevent pericarp damage and disease infection.A joint-type industrial manipulator with six degrees-of-freedom(DOF)was utilized to carry the end-effector.The key points and time steps for the collision-free and rapid motion of manipulator were planned.Experimental results showed that all the 100 mature strawberry targets were recognized automatically in the harvesting test.The success harvesting rate was 86%,and the success harvesting operation cost 31.3 seconds on average,including a single harvest operation of 10 seconds.The average error for fruit location was less than 4.6 mm.
