Purpose:.To discuss the incidence and clinical features of early and mid-late elevated intraocular pressure after pars plana vitrectomy and silicone oil injection, and to evaluate the clinical management of eyes with ...Purpose:.To discuss the incidence and clinical features of early and mid-late elevated intraocular pressure after pars plana vitrectomy and silicone oil injection, and to evaluate the clinical management of eyes with secondary glaucoma.Methods:.This was an observational consecutive case series of 691 eyes in 679 patients who were treated with pars plana vitrectomy and silicone injection...The diagnostic criteria of early elevated intraocular pressure after silicone oil injection was ≥21 mmHg two weeks after surgery, while mid-late elevated intraocular pressure was ≥21 mmHg after two weeks.The incidence and clinical management of elevated intraocular pressure were analyzed.Results: In total, 211 of 691 eyes(30.54%) developed elevated intraocular pressure two weeks after pars plana vitrecto my and silicone injection. Of the 211 eyes, 101 eyes(47.87%)had ocular inflammation, 64 eyes(30.33%) showed hyphema,35 eyes(16.59%) had silicone oil in the anterior chamber, 6eyes.(2.84%).had excess silicone oil injected,.and 5 eyes(2.37%).had rubeosis irides..Eighty three of 691 eyes(12.01%).developed elevated intraocular pressure after two weeks..Of these 83 eyes, 25 eyes(30.12%) had rubeosis irides,.16 eyes(19.27%) had issues related to topic steroid therapy,.13 eyes.(15.66%).had a papillary block,.silicone oil in the anterior chamber,10 eyes(12.05%) had a silicone emulsion,.10 eyes(12.05%).had peripheral anterior synchiae,.and 9 eyes(10.84%).had silicone oil in the anterior chamber..All eyes with elevated intraocular pressure were treated with antiglaucoma medications and surgeries.Conclusion:.The reasons for elevated intraocular pressure differed between early and mid-late after pars plana vitrectomy and silicone oil injection. The elevated intraocular pressure can be controlled effectively by immediate diagnosis and proper treatment with medicine and operation.展开更多
目的探讨老年白内障手术患者术后眼压升高的影响因素。方法采用整群抽样方式选取2020年6月至2023年6月该院眼科收治的进行手术治疗的老年白内障患者182例作为研究对象,经医院电子病历系统收集相关资料,分析老年白内障手术患者术后眼压...目的探讨老年白内障手术患者术后眼压升高的影响因素。方法采用整群抽样方式选取2020年6月至2023年6月该院眼科收治的进行手术治疗的老年白内障患者182例作为研究对象,经医院电子病历系统收集相关资料,分析老年白内障手术患者术后眼压升高的影响因素。结果182例患者中术后眼压升高16例(8.79%)。不同年龄、眼部炎症反应、手术时间、合并基础疾病、术后眼压波动、晶状体皮质或黏弹剂残留患者术后眼压升高发生率比较,差异均有统计学意义(P<0.05);不同病程、使用糖皮质激素、性别、高度近视、术眼、遗传史患者术后眼压升高发生率比较,差异均无统计学意义(P>0.05);年龄大于或等于70岁、手术时间大于或等于3 h、有眼部炎症反应、术后眼压波动大于或等于8 mm Hg、合并基础疾病、有晶状体皮质或黏弹剂残留是老年白内障手术患者术后发生眼压升高的危险因素,差异均有统计学意义(P<0.05)。结论老年白内障手术患者术后眼压升高与年龄、眼部炎症反应、手术时间、合并基础疾病、术后眼压波动、晶状体皮质或黏弹剂残留有关。展开更多
A rat model of acute high intraocular pressure was established by injecting saline into the anterior chamber of the left eye. Synaptophysin expression was increased in the inner plexiform layer at 2 hours following in...A rat model of acute high intraocular pressure was established by injecting saline into the anterior chamber of the left eye. Synaptophysin expression was increased in the inner plexiform layer at 2 hours following injury, and was widely distributed in the outer plexiform layer at 3-7 days, and then decreased to the normal level at 14 days. This suggests that expression of this presynaptic functional protein experienced spatiotemporal alterations after elevation of intraocular pressure. There was no significant change in the fluorescence intensity and distribution pattern for synapse-associated protein 102 following elevated intraocular pressure. Synapse-associated protein 102 immunoreactivity was confined to the outer plexiform layer, while synaptophysin immunoreactivity spread into the outer plexiform layer and the outer nuclear layer at 3 and 7 days following injury. These alterations in presynaptic elements were not accompanied by changes in postsynaptic components.展开更多
AIM: To analyze changes of the optic nerve head(ONH) and peripapillary region during intraocular pressure(IOP) elevation in patients using spectral domain optical coherence tomography(SD-OCT).METHODS: Both an optic di...AIM: To analyze changes of the optic nerve head(ONH) and peripapillary region during intraocular pressure(IOP) elevation in patients using spectral domain optical coherence tomography(SD-OCT).METHODS: Both an optic disc 200×200 cube scan and a high-definition 5-line raster scan were obtained from open angle glaucoma patients presented with monocular elevation of IOP(≥30 mm Hg) using SD-OCT. Additional baseline characteristics included age, gender, diagnosis,best-corrected visual acuity, refractive error, findings of slit lamp biomicroscopy, findings of dilated stereoscopic examination of the ONH and fundus, IOP, pachymetry findings, and the results of visual field.RESULTS: The 24 patients were selected and divided into two groups: group 1 patients had no history of IOP elevation or glaucoma(n =14), and group 2 patients did have history of IOP elevation or glaucoma(n =10). In each patient, the study eye with elevated IOP was classified into group H(high), and the fellow eye was classified into group L(low). The mean deviation(MD)differed significantly between groups H and L when all eyes were considered(P =0.047) and in group 2(P =0.042), not in group 1(P =0.893). Retinal nerve fiber layer(RNFL) average thickness(P =0.050), rim area(P =0.015),vertical cup/disc ratio(P =0.011), cup volume(P =0.028),inferior quadrant RNFL thickness(P =0.017), and clockhour(1, 5, and 6) RNFL thicknesses(P =0.050, 0.012, and0.018, respectively), cup depth(P =0.008), central prelaminar layer thickness(P =0.023), mid-inferior prelaminar layer thickness(P =0.023), and nasal retinal slope(P =0.034)were significantly different between the eyes with groups H and L.CONCLUSION:RNFLaveragethickness,rim area,vertical cup/disc ratio, cup volume, inferior quadrant RNFL thickness, and clock-hour(1, 5, and 6) RNFL thicknesses significantly changed during acute IOP elevation.展开更多
文摘Purpose:.To discuss the incidence and clinical features of early and mid-late elevated intraocular pressure after pars plana vitrectomy and silicone oil injection, and to evaluate the clinical management of eyes with secondary glaucoma.Methods:.This was an observational consecutive case series of 691 eyes in 679 patients who were treated with pars plana vitrectomy and silicone injection...The diagnostic criteria of early elevated intraocular pressure after silicone oil injection was ≥21 mmHg two weeks after surgery, while mid-late elevated intraocular pressure was ≥21 mmHg after two weeks.The incidence and clinical management of elevated intraocular pressure were analyzed.Results: In total, 211 of 691 eyes(30.54%) developed elevated intraocular pressure two weeks after pars plana vitrecto my and silicone injection. Of the 211 eyes, 101 eyes(47.87%)had ocular inflammation, 64 eyes(30.33%) showed hyphema,35 eyes(16.59%) had silicone oil in the anterior chamber, 6eyes.(2.84%).had excess silicone oil injected,.and 5 eyes(2.37%).had rubeosis irides..Eighty three of 691 eyes(12.01%).developed elevated intraocular pressure after two weeks..Of these 83 eyes, 25 eyes(30.12%) had rubeosis irides,.16 eyes(19.27%) had issues related to topic steroid therapy,.13 eyes.(15.66%).had a papillary block,.silicone oil in the anterior chamber,10 eyes(12.05%) had a silicone emulsion,.10 eyes(12.05%).had peripheral anterior synchiae,.and 9 eyes(10.84%).had silicone oil in the anterior chamber..All eyes with elevated intraocular pressure were treated with antiglaucoma medications and surgeries.Conclusion:.The reasons for elevated intraocular pressure differed between early and mid-late after pars plana vitrectomy and silicone oil injection. The elevated intraocular pressure can be controlled effectively by immediate diagnosis and proper treatment with medicine and operation.
文摘目的探讨老年白内障手术患者术后眼压升高的影响因素。方法采用整群抽样方式选取2020年6月至2023年6月该院眼科收治的进行手术治疗的老年白内障患者182例作为研究对象,经医院电子病历系统收集相关资料,分析老年白内障手术患者术后眼压升高的影响因素。结果182例患者中术后眼压升高16例(8.79%)。不同年龄、眼部炎症反应、手术时间、合并基础疾病、术后眼压波动、晶状体皮质或黏弹剂残留患者术后眼压升高发生率比较,差异均有统计学意义(P<0.05);不同病程、使用糖皮质激素、性别、高度近视、术眼、遗传史患者术后眼压升高发生率比较,差异均无统计学意义(P>0.05);年龄大于或等于70岁、手术时间大于或等于3 h、有眼部炎症反应、术后眼压波动大于或等于8 mm Hg、合并基础疾病、有晶状体皮质或黏弹剂残留是老年白内障手术患者术后发生眼压升高的危险因素,差异均有统计学意义(P<0.05)。结论老年白内障手术患者术后眼压升高与年龄、眼部炎症反应、手术时间、合并基础疾病、术后眼压波动、晶状体皮质或黏弹剂残留有关。
基金sponsored by the Ph.D.Programs Foundation of the Ministry of Education of China,No20090162110019the Natural Science Foundation of Hunan Province,No. 10JJ4023+1 种基金the Fundamental Research Funds for the Central Universities of China,No. 2011QNZT128Graduate Scientific Research Innovation Projects of Hunan Province in 2011,No. CX2011B047
文摘A rat model of acute high intraocular pressure was established by injecting saline into the anterior chamber of the left eye. Synaptophysin expression was increased in the inner plexiform layer at 2 hours following injury, and was widely distributed in the outer plexiform layer at 3-7 days, and then decreased to the normal level at 14 days. This suggests that expression of this presynaptic functional protein experienced spatiotemporal alterations after elevation of intraocular pressure. There was no significant change in the fluorescence intensity and distribution pattern for synapse-associated protein 102 following elevated intraocular pressure. Synapse-associated protein 102 immunoreactivity was confined to the outer plexiform layer, while synaptophysin immunoreactivity spread into the outer plexiform layer and the outer nuclear layer at 3 and 7 days following injury. These alterations in presynaptic elements were not accompanied by changes in postsynaptic components.
文摘AIM: To analyze changes of the optic nerve head(ONH) and peripapillary region during intraocular pressure(IOP) elevation in patients using spectral domain optical coherence tomography(SD-OCT).METHODS: Both an optic disc 200×200 cube scan and a high-definition 5-line raster scan were obtained from open angle glaucoma patients presented with monocular elevation of IOP(≥30 mm Hg) using SD-OCT. Additional baseline characteristics included age, gender, diagnosis,best-corrected visual acuity, refractive error, findings of slit lamp biomicroscopy, findings of dilated stereoscopic examination of the ONH and fundus, IOP, pachymetry findings, and the results of visual field.RESULTS: The 24 patients were selected and divided into two groups: group 1 patients had no history of IOP elevation or glaucoma(n =14), and group 2 patients did have history of IOP elevation or glaucoma(n =10). In each patient, the study eye with elevated IOP was classified into group H(high), and the fellow eye was classified into group L(low). The mean deviation(MD)differed significantly between groups H and L when all eyes were considered(P =0.047) and in group 2(P =0.042), not in group 1(P =0.893). Retinal nerve fiber layer(RNFL) average thickness(P =0.050), rim area(P =0.015),vertical cup/disc ratio(P =0.011), cup volume(P =0.028),inferior quadrant RNFL thickness(P =0.017), and clockhour(1, 5, and 6) RNFL thicknesses(P =0.050, 0.012, and0.018, respectively), cup depth(P =0.008), central prelaminar layer thickness(P =0.023), mid-inferior prelaminar layer thickness(P =0.023), and nasal retinal slope(P =0.034)were significantly different between the eyes with groups H and L.CONCLUSION:RNFLaveragethickness,rim area,vertical cup/disc ratio, cup volume, inferior quadrant RNFL thickness, and clock-hour(1, 5, and 6) RNFL thicknesses significantly changed during acute IOP elevation.
