Embryo in uterine implantation is a complex and multifactor-related process and is a downstream and ideal point for woman fertility control. Understanding the cellular and molecular mechanism of implantation is a prer...Embryo in uterine implantation is a complex and multifactor-related process and is a downstream and ideal point for woman fertility control. Understanding the cellular and molecular mechanism of implantation is a prerequisite for development of anti-implantation contraceptives. In spite of considerable accumulation of information from the laboratory animals that has been achieved, it is difficult to generate such information in human due to ethical restriction and experimental limitation, and the present knowledge for understanding the definitive mechanisms which control these events remains elusive. Embryo implantation can also occur outside uterus. Some women with abdominal pregnancies could successfully complete the processes of gestation and bear normal babies, implying that implantation itself may be not an endometrium-specific process. Reproductive biologists should cooperate with gynecologists to further comparatively study the molecular and cellular mechanisms of implantation normally occurring in endometrium and abnormally appearing outside uterine cavity. Such collaborative studies may generate new important information for developing anti-implantation contraceptive and for techniques of accurate diagnosis of ectopic pregnancy. A specially designed GnRH-2 analog and a combination use of low dose RU486 and gossypol as anti-implantation contraceptives have been suggested. Keywords embryo implantation - implantation window - materno-embryonic dialogue - ectopic pregnancy展开更多
Subcutaneous implantation of benign thyroid tissue is a rare complication of thyroid surgery. Here the authors report two cases of subcutaneous implantation of benign thyroid tissue following conventional thyroid surg...Subcutaneous implantation of benign thyroid tissue is a rare complication of thyroid surgery. Here the authors report two cases of subcutaneous implantation of benign thyroid tissue following conventional thyroid surgery. The diagnosis and differential diagnosis of cervical subcutaneous thyroid tissue implantation, and their clinical pathological characteristics are retrospectively investigated. The mechanism of the implantation process is analyzed. The management of patient with cervical subcutaneous soft tissue implantation is also discussed.展开更多
Severe crushing injuries to the distal forearm can preclude immediate hand replantation,with temporary ectopic implantation as a practicable option under special circumstances.This report describes a case of temporary...Severe crushing injuries to the distal forearm can preclude immediate hand replantation,with temporary ectopic implantation as a practicable option under special circumstances.This report describes a case of temporary ectopic hand implantation for a crush injury extending from the wrist to the middle third of the forearm,using the left foot as the recipient site.The hand was replanted onto the left forearm 3 months after the ectopic implantation,with functional gains seen by 18 months.Satisfactory ambulation was retained,with no reported foot pain.Temporary ectopic implantation is a pragmatic alternative under select circumstances.展开更多
基金This work was supported by WHO/Rockefeller Foundation(RF96020#78)CONRAD/CICCR(CIG-01-71)+2 种基金CAS Chuangxi(KSCX-2-SW-201)'973'(G1999055901)National Natural Science Foundation of China(Grant Nos.39970284,90208025,30170452,30370200).
文摘Embryo in uterine implantation is a complex and multifactor-related process and is a downstream and ideal point for woman fertility control. Understanding the cellular and molecular mechanism of implantation is a prerequisite for development of anti-implantation contraceptives. In spite of considerable accumulation of information from the laboratory animals that has been achieved, it is difficult to generate such information in human due to ethical restriction and experimental limitation, and the present knowledge for understanding the definitive mechanisms which control these events remains elusive. Embryo implantation can also occur outside uterus. Some women with abdominal pregnancies could successfully complete the processes of gestation and bear normal babies, implying that implantation itself may be not an endometrium-specific process. Reproductive biologists should cooperate with gynecologists to further comparatively study the molecular and cellular mechanisms of implantation normally occurring in endometrium and abnormally appearing outside uterine cavity. Such collaborative studies may generate new important information for developing anti-implantation contraceptive and for techniques of accurate diagnosis of ectopic pregnancy. A specially designed GnRH-2 analog and a combination use of low dose RU486 and gossypol as anti-implantation contraceptives have been suggested. Keywords embryo implantation - implantation window - materno-embryonic dialogue - ectopic pregnancy
文摘Subcutaneous implantation of benign thyroid tissue is a rare complication of thyroid surgery. Here the authors report two cases of subcutaneous implantation of benign thyroid tissue following conventional thyroid surgery. The diagnosis and differential diagnosis of cervical subcutaneous thyroid tissue implantation, and their clinical pathological characteristics are retrospectively investigated. The mechanism of the implantation process is analyzed. The management of patient with cervical subcutaneous soft tissue implantation is also discussed.
文摘Severe crushing injuries to the distal forearm can preclude immediate hand replantation,with temporary ectopic implantation as a practicable option under special circumstances.This report describes a case of temporary ectopic hand implantation for a crush injury extending from the wrist to the middle third of the forearm,using the left foot as the recipient site.The hand was replanted onto the left forearm 3 months after the ectopic implantation,with functional gains seen by 18 months.Satisfactory ambulation was retained,with no reported foot pain.Temporary ectopic implantation is a pragmatic alternative under select circumstances.
