OBJECTIVE: To evaluate the therapeutic effects of low-frequency phonophoresis with a Chinese herbal medicine(CHM) compared with sodium diclofenac(SD) for knee osteoarthritis(KOA).METHODS: In this double-blind, randomi...OBJECTIVE: To evaluate the therapeutic effects of low-frequency phonophoresis with a Chinese herbal medicine(CHM) compared with sodium diclofenac(SD) for knee osteoarthritis(KOA).METHODS: In this double-blind, randomized, placebo-controlled trial, 100 KOA patients were assigned randomly to a placebo group, a CHM group,or SD group. Low-frequency phonophoresis was used to improve the efficiency of drug delivery.Pain at rest [using a visual analog scale(VAS)], pain on movement(VAS), and range of motion(degrees) in the three groups were evaluated using the Western Ontario and Mc Master Universities Osteoarthritis Index(WOMACAI) scores. Safety assessments comprised emergency adverse events, aswell as laboratory tests of blood biochemistry, creatinine, blood urea nitrogen, alanine aminotransferase and aspartate aminotransferase.RESULTS: Significant improvements were found after treatment in all outcome measures except stiffness and range of motion in patients in the CHMP group and SDP group(P < 0.05). No significant differences in all outcome measures were found between the CHMP group and SDP group.CONCLUSION: CHMP and SDP can show good therapeutic effects for KOA in terms of relieving pain and improving physical function.展开更多
The major ingredients of grassleaf sweetflag rhizome are β-asarone and eugenol, which can cross the blood-brain barrier and protect neurons. This study aimed to observe the neuroprotective effects and mechanisms of ...The major ingredients of grassleaf sweetflag rhizome are β-asarone and eugenol, which can cross the blood-brain barrier and protect neurons. This study aimed to observe the neuroprotective effects and mechanisms of β-asarone and eugenol, components of the Chinese herb grassleaf sweetflag rhizome, on PC12 cells. First, PC12 cells were cultured with different concentrations（between 1 × 10–10 M and 1 × 10–5 M） of β-asarone and eugenol. Survival rates of PC12 cells were not significantly affected. Second, PC12 cells incubated with amyloid-beta42, which reduced cell survival, were cultured under the same conditions（1 × 10–6 M β-asarone and eugenol）. The survival rates of PC12 cells significantly increased, while expression levels of the m RNAs for the pro-apoptotic protein Bax decreased, and those for the anti-apoptotic protein Bcl m RNA increased. In addition, the combination of β-asarone with eugenol achieved better results than either component alone. Our experimental findings indicate that both β-asarone and eugenol protect PC12 cells through inhibiting apoptosis, and that the combination of the two is better than either alone.展开更多
基金Supported by State Administration of Traditional Chinese Medicine("Eleventh Five-Year"Key Discipline Construction Projects)Beijing Municipal Administration of Traditional Chinese Medicine(External Treatment Special Fund,No.WZF2012-09)
文摘OBJECTIVE: To evaluate the therapeutic effects of low-frequency phonophoresis with a Chinese herbal medicine(CHM) compared with sodium diclofenac(SD) for knee osteoarthritis(KOA).METHODS: In this double-blind, randomized, placebo-controlled trial, 100 KOA patients were assigned randomly to a placebo group, a CHM group,or SD group. Low-frequency phonophoresis was used to improve the efficiency of drug delivery.Pain at rest [using a visual analog scale(VAS)], pain on movement(VAS), and range of motion(degrees) in the three groups were evaluated using the Western Ontario and Mc Master Universities Osteoarthritis Index(WOMACAI) scores. Safety assessments comprised emergency adverse events, aswell as laboratory tests of blood biochemistry, creatinine, blood urea nitrogen, alanine aminotransferase and aspartate aminotransferase.RESULTS: Significant improvements were found after treatment in all outcome measures except stiffness and range of motion in patients in the CHMP group and SDP group(P < 0.05). No significant differences in all outcome measures were found between the CHMP group and SDP group.CONCLUSION: CHMP and SDP can show good therapeutic effects for KOA in terms of relieving pain and improving physical function.
基金financially supported by a grant from Guangdong Provincial Science and Technology Plan Program of China,No.2010B060900085
文摘The major ingredients of grassleaf sweetflag rhizome are β-asarone and eugenol, which can cross the blood-brain barrier and protect neurons. This study aimed to observe the neuroprotective effects and mechanisms of β-asarone and eugenol, components of the Chinese herb grassleaf sweetflag rhizome, on PC12 cells. First, PC12 cells were cultured with different concentrations（between 1 × 10–10 M and 1 × 10–5 M） of β-asarone and eugenol. Survival rates of PC12 cells were not significantly affected. Second, PC12 cells incubated with amyloid-beta42, which reduced cell survival, were cultured under the same conditions（1 × 10–6 M β-asarone and eugenol）. The survival rates of PC12 cells significantly increased, while expression levels of the m RNAs for the pro-apoptotic protein Bax decreased, and those for the anti-apoptotic protein Bcl m RNA increased. In addition, the combination of β-asarone with eugenol achieved better results than either component alone. Our experimental findings indicate that both β-asarone and eugenol protect PC12 cells through inhibiting apoptosis, and that the combination of the two is better than either alone.
