Maytansine （I） (C34H46CIN3O10) is a novel type of ansa macrolide with potent antitumor activity. It was isolated by Kupchan et al. with great efforts from several Maytenus species （0.2 p.p.m.—1.5 p.p.m, dried plan...Maytansine （I） (C34H46CIN3O10) is a novel type of ansa macrolide with potent antitumor activity. It was isolated by Kupchan et al. with great efforts from several Maytenus species （0.2 p.p.m.—1.5 p.p.m, dried plant material） collected in Kenya and Ethiopia. It showed highly inhibitory activity against several experimental tumors （L-1210, P-388, W-256, S-180, Lewis lung carcinoma and B-16 melanocarcinoma） at the level of micrograms per kilogram body weight and the safety dosage ranging about 50—100 folds. Therefore, maytansine has been considered as one of the most promising anticancer agent of natural origin, attracting the interest of many relevant scientists.展开更多
The purpose of this study was to elucidate the relationship between percentage of body lipid and individual vitamin B6 contents in the anchovy used for production of Japanese soup stock. The contents of individual vit...The purpose of this study was to elucidate the relationship between percentage of body lipid and individual vitamin B6 contents in the anchovy used for production of Japanese soup stock. The contents of individual vitamin B6 compound in foods should be determined to estimate the functionality of foods. Anchovies （Engraulisjaponica） for use as production of iriko, which is a raw material for preparation of Japanese soup stock, were caught using a medium-sized purse seine on May 26th, June 1st, and July 6th 2011 in Tachibana Bay, Nagasaki, Japan. Vitamin B6 contents were analyzed by 4-pyridoxolacone-coversion （all-enzymatic） HPLC. The relationship between body length, lipid content and the individual contents of vitamin B6 compounds in the anchovies was determined. The propriety of anchovies for iriko preparation could not be estimated based on the appearance of length of fishes. The anchovies were rich in vitamin B6, especially pyridoxamine 5＇-phosphate, which may prevent diabetic complications. The percentage of body lipid significantly showed a negative correlation with the content of pyridoxamine 5＇-phosphate. The contents of the other vitamin B6 compounds did not show the significant correlation with the percentage of body lipid.展开更多
在基础饲料中分别添加0、10%、20%、30%、40%的玉米干酒精糟及其可溶物(Dried distiller's grains with solubles,DDGS),配制成5种等氮等能的实验饲料(DDGS0、DDGS10、DDGS20、DDGS30和DDGS40),饲喂初始体重为(9.69±0.28)g的刺...在基础饲料中分别添加0、10%、20%、30%、40%的玉米干酒精糟及其可溶物(Dried distiller's grains with solubles,DDGS),配制成5种等氮等能的实验饲料(DDGS0、DDGS10、DDGS20、DDGS30和DDGS40),饲喂初始体重为(9.69±0.28)g的刺参56 d,研究玉米DDGS作为替代蛋白源对其生长、体成分及免疫指标的影响。结果显示,随着玉米DDGS添加水平的升高,刺参增重率和特定生长率略有下降,但各组间差异不显著(P>0.05)。各实验组刺参体壁指数、肠道指数、肠长比以及体壁水分、粗蛋白、粗脂肪和粗灰分含量均不受玉米DDGS添加的影响(P>0.05)。体腔液中溶菌酶的活性呈先上升后稳定的趋势,其中,DDGS20和DDGS40组显著高于DDGS0和DDGS10组(P<0.05),DDGS30组与其他各组无显著差异(P>0.05)。酸性磷酸酶的活性呈先上升后下降的趋势,在DDGS20组达到最大值,其中,DDGS20组显著高于其他各组(P<0.05),DDGS40组显著高于DDGS0组(P<0.05),其他各组间无显著差异(P>0.05)。酚氧化酶的活性随着DDGS添加量的增加呈上升趋势,各添加组均显著高于DDGS0组(P<0.05),DDGS40组显著高于DDGS10组(P<0.05),其他各组间无显著差异(P>0.05)。饲料中添加玉米DDGS对体腔液中碱性磷酸酶和超氧化物歧化酶的活性无显著影响(P>0.05)。本研究表明,饲料中添加0–40%的玉米DDGS均不影响刺参的生长和体壁成分,且添加20%–40%的玉米DDGS能提高刺参体腔液中免疫酶的活性。展开更多
文摘Maytansine （I） (C34H46CIN3O10) is a novel type of ansa macrolide with potent antitumor activity. It was isolated by Kupchan et al. with great efforts from several Maytenus species （0.2 p.p.m.—1.5 p.p.m, dried plant material） collected in Kenya and Ethiopia. It showed highly inhibitory activity against several experimental tumors （L-1210, P-388, W-256, S-180, Lewis lung carcinoma and B-16 melanocarcinoma） at the level of micrograms per kilogram body weight and the safety dosage ranging about 50—100 folds. Therefore, maytansine has been considered as one of the most promising anticancer agent of natural origin, attracting the interest of many relevant scientists.
文摘The purpose of this study was to elucidate the relationship between percentage of body lipid and individual vitamin B6 contents in the anchovy used for production of Japanese soup stock. The contents of individual vitamin B6 compound in foods should be determined to estimate the functionality of foods. Anchovies （Engraulisjaponica） for use as production of iriko, which is a raw material for preparation of Japanese soup stock, were caught using a medium-sized purse seine on May 26th, June 1st, and July 6th 2011 in Tachibana Bay, Nagasaki, Japan. Vitamin B6 contents were analyzed by 4-pyridoxolacone-coversion （all-enzymatic） HPLC. The relationship between body length, lipid content and the individual contents of vitamin B6 compounds in the anchovies was determined. The propriety of anchovies for iriko preparation could not be estimated based on the appearance of length of fishes. The anchovies were rich in vitamin B6, especially pyridoxamine 5＇-phosphate, which may prevent diabetic complications. The percentage of body lipid significantly showed a negative correlation with the content of pyridoxamine 5＇-phosphate. The contents of the other vitamin B6 compounds did not show the significant correlation with the percentage of body lipid.
