As one of the most lethal diseases,pancreatic cancer shows a dismal overall prognosis and high resistance to most treatment modalities.Furthermore,pancreatic cancer escapes early detection during the curable period be...As one of the most lethal diseases,pancreatic cancer shows a dismal overall prognosis and high resistance to most treatment modalities.Furthermore,pancreatic cancer escapes early detection during the curable period because early symptoms rarely emerge and specific markers for this disease have not been found.Although combinations of new drugs,multimodal therapies,and adjuvants prolong survival,most patients still relapse after surgery and eventually die.Consequently,the search for more effective treatments for pancreatic cancer is highly relevant and justified.As a newly re-discovered mediator of gasotransmission,hydrogen sulfide(H2S)undertakes essential functions,encompassing various signaling complexes that occupy key processes in human biology.Accumulating evidence indicates that H2S exhibits bimodal modulation of cancer development.Thus,endogenous or low levels of exogenous H2S are thought to promote cancer,whereas high doses of exogenous H2S suppress tumor proliferation.Similarly,inhibition of endogenous H2S production also suppresses tumor proliferation.Accordingly,H2S biosynthesis inhibitors and H2S supplementation(H2S donors)are two distinct strategies for the treatment of cancer.Unfortunately,modulation of endogenous H2S on pancreatic cancer has not been studied so far.However,H2S donors and their derivatives have been extensively studied as potential therapeutic agents for pancreatic cancer therapy by inhibiting cell proliferation,inducing apoptosis,arresting cell cycle,and suppressing invasion and migration through exploiting multiple signaling pathways.As far as we know,there is no review of the effects of H2S donors on pancreatic cancer.Based on these concerns,the therapeutic effects of some H2S donors and NO-H2S dual donors on pancreatic cancer were summarized in this paper.Exogenous H2S donors may be promising compounds for pancreatic cancer treatment.展开更多
A new method for the synthesis of azo Schiff an base ligand in which the azo and azomethine groups are coordination sites was developed through a Schiff base precursor. The precursor, N-4-methoxybenzylidene-3-hydroxyp...A new method for the synthesis of azo Schiff an base ligand in which the azo and azomethine groups are coordination sites was developed through a Schiff base precursor. The precursor, N-4-methoxybenzylidene-3-hydroxyphenylamine （SB） derived from 3-aminophenol was regioselectively coupled with a diazonium ion para to the hydroxyl group of the amine component of the Schiff base. The para selectivity was controlled by the directing effect of the hydroxyl group. The ligand and its nickel（Ⅱ） complex were characterized by elemental analyses, IR and UV-Vis spectroscopy. The analytical and spectral data supported the mononuclear formulation of the complex with metal to ligand ratio （M ： L = 1 ： 2） and suggested a square planar geometry for the complex.展开更多
X-ray single-crystal structure analysis,UV-Vis,and photoluminescent properties of organic compound,9-(4-(5-(6-methylpyridin-2-yl)-3-phenyl-1H-1,2,4-triazol-1-yl)phenyl)-9H-carbazole(compound 1)were studied.Compound 1 ...X-ray single-crystal structure analysis,UV-Vis,and photoluminescent properties of organic compound,9-(4-(5-(6-methylpyridin-2-yl)-3-phenyl-1H-1,2,4-triazol-1-yl)phenyl)-9H-carbazole(compound 1)were studied.Compound 1 crystallizes in monoclinic system,space group P2(1/c)with a=16.0434(9),b=17.920(1),c=8.3453(5)A,β=94.142(5)°,V=2393.0(2),Z=4,Mr=477.55,Dc=1.326 g/cm^3,F(000)=1000,μ=0.080 mm^–1,GOOF=1.025,the final R=0.0505 and wR=0.1226 for 4921 observed reflections with I>2σ(I).Compound 1 is a donor-acceptor type molecule,in which the carbazolyl group(cz)acts as an electron donor,and the group of 2-(1,3-diphenyl-1H-1,2,4-triazol-5-yl)-6-methylpyridine(MePyTz)as an electron acceptor.In methylene chloride,compound 1 exhibits deep blue luminescence with maximum at 440 nm,lifetime of 4.2 ns under N2 and quantum yield ofф=0.18 at room temperature.The experimental and computational results show that the emission of compound 1 originates from the lowest singlet excited state(S1)with charge transfer character.展开更多
Photoinduced electron transfer (ET) between C60 and porphyrin (P) in a new polymer containing porphyrin, poly(p-phenyle nevinylene), and pendant fullerene units has been investigated by nanosecond transient absorption...Photoinduced electron transfer (ET) between C60 and porphyrin (P) in a new polymer containing porphyrin, poly(p-phenyle nevinylene), and pendant fullerene units has been investigated by nanosecond transient absorption and phosphorescence spectroscopy. Compared to the physically doping material systems, binding porphyrin/C60 through chemical bonds in a polymer detains the formation of the triplet states of porphyrins and C60. The formation of intermediate charge transfer state (CSS) of P·+-C60·? was observed, which led to the delayed formation of triplet states of porphyrins and C60. The reduced opto-electronic properties, such as optical limiting performance, were also observed, which resulted from the delayed formation of triplet states. The results presented in this article are significant in understanding the complicated spectral characteristics of the triplet state and charge transfer of the porphyrin and C60 complexes, and are therefore related to the controllable performance of the new materials in applications.展开更多
The single crystal structure of the donor-acceptor ferrocenyl derivativeC18H15ClFe (Mr = 322. 62 ) has been determined, belonging to orthorhombic crystalsystem, space group P212121 with lattice parameters a= 11. 307 (...The single crystal structure of the donor-acceptor ferrocenyl derivativeC18H15ClFe (Mr = 322. 62 ) has been determined, belonging to orthorhombic crystalsystem, space group P212121 with lattice parameters a= 11. 307 (2), b= 8. 471 (2 ), c=15. 427(3) A, V= 1477. 7(9) A3, Z=4, D.= 1. 45 g. cm-3, λ(MoKα) =0. 71073A,μ= 11. 9 cm-1, F(000) = 664. The final R value for 1534 observed [I>3σ(I)] reflec-tions is 0. 060. The configuration of the C =C double bond is trans. The C5H4CH =CHC6H4Cl fragrnent is almost planar. The rings of ferrocene are almost in the eclipsedpositions with each other.展开更多
基金financially supported by Fok Ying Tung Education Foundation(171035,China)State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources(CMEMR2018-B04,Guangxi Normal University,China)+1 种基金Highlevel Innovative Project in Shenyang(Young and Middle-aged Technological Innovative Support Plan,RC190483,China)Career Development Support Plan in Shenyang Pharmaceutical University,China。
文摘As one of the most lethal diseases,pancreatic cancer shows a dismal overall prognosis and high resistance to most treatment modalities.Furthermore,pancreatic cancer escapes early detection during the curable period because early symptoms rarely emerge and specific markers for this disease have not been found.Although combinations of new drugs,multimodal therapies,and adjuvants prolong survival,most patients still relapse after surgery and eventually die.Consequently,the search for more effective treatments for pancreatic cancer is highly relevant and justified.As a newly re-discovered mediator of gasotransmission,hydrogen sulfide(H2S)undertakes essential functions,encompassing various signaling complexes that occupy key processes in human biology.Accumulating evidence indicates that H2S exhibits bimodal modulation of cancer development.Thus,endogenous or low levels of exogenous H2S are thought to promote cancer,whereas high doses of exogenous H2S suppress tumor proliferation.Similarly,inhibition of endogenous H2S production also suppresses tumor proliferation.Accordingly,H2S biosynthesis inhibitors and H2S supplementation(H2S donors)are two distinct strategies for the treatment of cancer.Unfortunately,modulation of endogenous H2S on pancreatic cancer has not been studied so far.However,H2S donors and their derivatives have been extensively studied as potential therapeutic agents for pancreatic cancer therapy by inhibiting cell proliferation,inducing apoptosis,arresting cell cycle,and suppressing invasion and migration through exploiting multiple signaling pathways.As far as we know,there is no review of the effects of H2S donors on pancreatic cancer.Based on these concerns,the therapeutic effects of some H2S donors and NO-H2S dual donors on pancreatic cancer were summarized in this paper.Exogenous H2S donors may be promising compounds for pancreatic cancer treatment.
文摘A new method for the synthesis of azo Schiff an base ligand in which the azo and azomethine groups are coordination sites was developed through a Schiff base precursor. The precursor, N-4-methoxybenzylidene-3-hydroxyphenylamine （SB） derived from 3-aminophenol was regioselectively coupled with a diazonium ion para to the hydroxyl group of the amine component of the Schiff base. The para selectivity was controlled by the directing effect of the hydroxyl group. The ligand and its nickel（Ⅱ） complex were characterized by elemental analyses, IR and UV-Vis spectroscopy. The analytical and spectral data supported the mononuclear formulation of the complex with metal to ligand ratio （M ： L = 1 ： 2） and suggested a square planar geometry for the complex.
基金the National Natural Science Foundation of China(51672271,21671190)。
文摘X-ray single-crystal structure analysis,UV-Vis,and photoluminescent properties of organic compound,9-(4-(5-(6-methylpyridin-2-yl)-3-phenyl-1H-1,2,4-triazol-1-yl)phenyl)-9H-carbazole(compound 1)were studied.Compound 1 crystallizes in monoclinic system,space group P2(1/c)with a=16.0434(9),b=17.920(1),c=8.3453(5)A,β=94.142(5)°,V=2393.0(2),Z=4,Mr=477.55,Dc=1.326 g/cm^3,F(000)=1000,μ=0.080 mm^–1,GOOF=1.025,the final R=0.0505 and wR=0.1226 for 4921 observed reflections with I>2σ(I).Compound 1 is a donor-acceptor type molecule,in which the carbazolyl group(cz)acts as an electron donor,and the group of 2-(1,3-diphenyl-1H-1,2,4-triazol-5-yl)-6-methylpyridine(MePyTz)as an electron acceptor.In methylene chloride,compound 1 exhibits deep blue luminescence with maximum at 440 nm,lifetime of 4.2 ns under N2 and quantum yield ofф=0.18 at room temperature.The experimental and computational results show that the emission of compound 1 originates from the lowest singlet excited state(S1)with charge transfer character.
基金supported by the National Natural Science Foundation of China, 973 Programs and Chinese Academy of Sciences
文摘Photoinduced electron transfer (ET) between C60 and porphyrin (P) in a new polymer containing porphyrin, poly(p-phenyle nevinylene), and pendant fullerene units has been investigated by nanosecond transient absorption and phosphorescence spectroscopy. Compared to the physically doping material systems, binding porphyrin/C60 through chemical bonds in a polymer detains the formation of the triplet states of porphyrins and C60. The formation of intermediate charge transfer state (CSS) of P·+-C60·? was observed, which led to the delayed formation of triplet states of porphyrins and C60. The reduced opto-electronic properties, such as optical limiting performance, were also observed, which resulted from the delayed formation of triplet states. The results presented in this article are significant in understanding the complicated spectral characteristics of the triplet state and charge transfer of the porphyrin and C60 complexes, and are therefore related to the controllable performance of the new materials in applications.
文摘The single crystal structure of the donor-acceptor ferrocenyl derivativeC18H15ClFe (Mr = 322. 62 ) has been determined, belonging to orthorhombic crystalsystem, space group P212121 with lattice parameters a= 11. 307 (2), b= 8. 471 (2 ), c=15. 427(3) A, V= 1477. 7(9) A3, Z=4, D.= 1. 45 g. cm-3, λ(MoKα) =0. 71073A,μ= 11. 9 cm-1, F(000) = 664. The final R value for 1534 observed [I>3σ(I)] reflec-tions is 0. 060. The configuration of the C =C double bond is trans. The C5H4CH =CHC6H4Cl fragrnent is almost planar. The rings of ferrocene are almost in the eclipsedpositions with each other.
