Heterocyclic skeleton building blocks to afford dihydropyrimidinones and dihydropyridines based on neat adducts of diketene, alcohols and aldehydes via silica sulfuric acid （SSA） catalyzed ring opening of diketene i...Heterocyclic skeleton building blocks to afford dihydropyrimidinones and dihydropyridines based on neat adducts of diketene, alcohols and aldehydes via silica sulfuric acid （SSA） catalyzed ring opening of diketene in four-component Biginelli-type and Hantzsch-type reactions are presented.展开更多
We demonstrated herein an electrochemical dearomatizative alkylation of Katritzky salts,wherein Katritzky salts were harnessed as both radical acceptors and donors.A wide range of privileged dihydropyridine scaffolds ...We demonstrated herein an electrochemical dearomatizative alkylation of Katritzky salts,wherein Katritzky salts were harnessed as both radical acceptors and donors.A wide range of privileged dihydropyridine scaffolds was constructed with good to excellent yields.Cyclic voltammetry(CV)and electron paramagnetic resonance(EPR)results confirmed the key intermediates-dihydropyridine radicals and gram-scale reaction highlighted the practical and sustainable feature of the newly developed protocol.展开更多
文摘Heterocyclic skeleton building blocks to afford dihydropyrimidinones and dihydropyridines based on neat adducts of diketene, alcohols and aldehydes via silica sulfuric acid （SSA） catalyzed ring opening of diketene in four-component Biginelli-type and Hantzsch-type reactions are presented.
基金the National Natural Science Foundation of China(Nos.22171154 and 21801144)the Youth Innovative Talents Recruitment and Cultivation Program of Shandong Higher Education,the Natural Science Foundation of Shandong Province(Nos.ZR2020QB114 and ZR2020QB008)+4 种基金Jinan Science&Technology Bureau(No.2021GXRC080)supported by the Foundation(No.ZZ20190312)of State Key Laboratory of Biobased Material and Green Papermaking,Qilu University of Technology(Shandong Academy of Sciences)the Program for Scientific Research Innovation Team in Colleges and Universities of Shandong Province,the Open Fund of the Department of Chemistry,Qingdao University of Science and Technology(No.QUSTHX202010)Science and Technology Innovation Development Plan of Yantai(No.2020MSGY114)Yantai“Double Hundred Plan”.
文摘We demonstrated herein an electrochemical dearomatizative alkylation of Katritzky salts,wherein Katritzky salts were harnessed as both radical acceptors and donors.A wide range of privileged dihydropyridine scaffolds was constructed with good to excellent yields.Cyclic voltammetry(CV)and electron paramagnetic resonance(EPR)results confirmed the key intermediates-dihydropyridine radicals and gram-scale reaction highlighted the practical and sustainable feature of the newly developed protocol.
