Gastric cancer is a common, worldwide malignancy and has a poor prognosis due to late diagnosis. Long non-coding RNAs(lnc RNAs) are a significant subtype of RNA molecules with a length longer than 200 nucleotides(nt) ...Gastric cancer is a common, worldwide malignancy and has a poor prognosis due to late diagnosis. Long non-coding RNAs(lnc RNAs) are a significant subtype of RNA molecules with a length longer than 200 nucleotides(nt) that rarely encode proteins. In recent decades, deregulation of lnc RNAs has been shown to be involved in tumorigenesis and tumor progression in various human carcinomas, including gastric cancer. Accumulating evidence has shown that some lnc RNAs may function as diagnostic biomarkers or therapeutic targets for gastric cancer. Thus, exploring the specific functions of lnc RNAs will help both gain a better understanding of the pathogenesis and develop novel treatments for gastric cancer. In this review, we highlight the expression and functional roles of lncR NAs in gastric cancer, and analyze the potential applications of lncR NAs as diagnostic markers and therapeutic targets.展开更多
Fabric-based composites with superior mechanical properties and excellent perceptive function are highly desirable.However,it remains a huge challenge to attain structure-function integration,especially for hybrid fab...Fabric-based composites with superior mechanical properties and excellent perceptive function are highly desirable.However,it remains a huge challenge to attain structure-function integration,especially for hybrid fabric composites.Herein,a skin-inspired interface modification strategy is proposed toward this target by constructing a hybrid smart fabric system consisting of two types of smart fabrics:carbon nanotube(CNT)/MXene-modified aramid fabrics and zinc oxide nanorod(ZnO NR)-modified carbon fabrics.Based on that,flexible piezoelectric pressure sensors with skin-like hierarchical perception interfaces are fabricated,which demonstrate superb sensitivity of 2.39 V·kPa^(-1)and are capable of various wearable monitoring tasks.Besides,the interface-modified hybrid fabric reinforced plastics can also be fabricated,which are proven to possess 13.6%higher tensile strength,10.1%elastic modulus.More impressively,their average energy absorption can be improved by 111.9%,accompanied with inherent damage alert capability.This offers a paradigm to fabricate structure-function integrated hybrid smart fabric composites for the smart clothing and intelligent aerial vehicles.展开更多
文摘Gastric cancer is a common, worldwide malignancy and has a poor prognosis due to late diagnosis. Long non-coding RNAs(lnc RNAs) are a significant subtype of RNA molecules with a length longer than 200 nucleotides(nt) that rarely encode proteins. In recent decades, deregulation of lnc RNAs has been shown to be involved in tumorigenesis and tumor progression in various human carcinomas, including gastric cancer. Accumulating evidence has shown that some lnc RNAs may function as diagnostic biomarkers or therapeutic targets for gastric cancer. Thus, exploring the specific functions of lnc RNAs will help both gain a better understanding of the pathogenesis and develop novel treatments for gastric cancer. In this review, we highlight the expression and functional roles of lncR NAs in gastric cancer, and analyze the potential applications of lncR NAs as diagnostic markers and therapeutic targets.
基金supported by the National Natural Science Foundation of China(Nos.52205298,52375280 and 51775022)Project funded by China Postdoctoral Science Foundation(Nos.2022M710302 and 2022TQ0023)the Fundamental Research Funds for the Central Universities.
文摘Fabric-based composites with superior mechanical properties and excellent perceptive function are highly desirable.However,it remains a huge challenge to attain structure-function integration,especially for hybrid fabric composites.Herein,a skin-inspired interface modification strategy is proposed toward this target by constructing a hybrid smart fabric system consisting of two types of smart fabrics:carbon nanotube(CNT)/MXene-modified aramid fabrics and zinc oxide nanorod(ZnO NR)-modified carbon fabrics.Based on that,flexible piezoelectric pressure sensors with skin-like hierarchical perception interfaces are fabricated,which demonstrate superb sensitivity of 2.39 V·kPa^(-1)and are capable of various wearable monitoring tasks.Besides,the interface-modified hybrid fabric reinforced plastics can also be fabricated,which are proven to possess 13.6%higher tensile strength,10.1%elastic modulus.More impressively,their average energy absorption can be improved by 111.9%,accompanied with inherent damage alert capability.This offers a paradigm to fabricate structure-function integrated hybrid smart fabric composites for the smart clothing and intelligent aerial vehicles.
