Group 2 innate lymphoid cells(ILC2s)are a category of heterogeneous cells that produce the cytokines IL-5 and IL-13,which mediate the type 2 immune response.However,specific drug targets on lung ILC2s have rarely been...Group 2 innate lymphoid cells(ILC2s)are a category of heterogeneous cells that produce the cytokines IL-5 and IL-13,which mediate the type 2 immune response.However,specific drug targets on lung ILC2s have rarely been reported.Previous studies have shown that type 2 cytokines,such as IL-5 and IL-13,are related to depression.Here,we demonstrated the negative correlation between the depression-associated monoamine neurotransmitter serotonin and secretion of the cytokines IL-5 and IL-13 by ILC2s in individuals with depression.Interestingly,serotonin ameliorates papain-induced lung inflammation by suppressing ILC2 activation.Our data showed that the serotonin receptor HTR2A was highly expressed on ILC2s from mouse lungs and human PBMCs.Furthermore,an HTR2A selective agonist(DOI)impaired ILC2 activation and alleviated the type 2 immune response in vivo and in vitro.Mice with ILC2-specific depletion of HTR2A(Il5^(cre/+)·Htr2a^(flox/flox)mice)abolished the DOI-mediated inhibition of ILC2s in a papain-induced mouse model of inflammation.In conclusion,serotonin and DOI could restrict the type 2 lung immune response,indicating a potential treatment strategy for type 2 lung inflammation by targeting HTR2A on ST2+ILC2s.展开更多
With the development of computer graphics, the three-dimensional (3D) visualization brings new technological revolution to the traditional cartography. Therefore, the topographic 3D-map emerges to adapt to this techno...With the development of computer graphics, the three-dimensional (3D) visualization brings new technological revolution to the traditional cartography. Therefore, the topographic 3D-map emerges to adapt to this technological revolution, and the applications of topographic 3D-map are spread rapidly to other relevant fields due to its incomparable advantage. The researches on digital map and the construction of map database offer strong technical support and abundant data source for this new technology, so the research and development of topographic 3D-map will receive greater concern. The basic data of the topographic 3D-map are rooted mainly in digital map and its basic model is derived from digital elevation model (DEM) and 3D-models of other DEM-based geographic features. In view of the potential enormous data and the complexity of geographic features, the dynamic representation of geographic information becomes the focus of the research of topographic 3D-map and also the prerequisite condition of 3D query and analysis. In addition to the equipment of hardware that are restraining, to a certain extent, the 3D representation, the data organization structure of geographic information will be the core problem of research on 3D-map. Level of detail (LOD), space partitioning, dynamic object loading (DOL) and object culling are core technologies of the dynamic 3D representation. The object- selection, attribute-query and model-editing are important functions and interaction tools for users with 3D-maps provided by topographic 3D-map system, all of which are based on the data structure of the 3D-model. This paper discusses the basic theories, concepts and cardinal principles of topographic 3D-map, expounds the basic way to organize the scene hierarchy of topographic 3D-map based on the node mechanism and studies the dynamic representation technologies of topographic 3D-map based on LOD, space partitioning, DOL and object culling. Moreover, such interactive operation functions are explored, in this paper, as spatial q展开更多
介绍了一种新的宽带接入技术DOL(DOCSIS over LAN),作为网络带宽扩容技术方案的一种新选择,讲解了方案实现的原理、机房端设备DOLc、用户接入端设备DOL Modem的体系结构,以及该系统优缺点及扩容方案的成本比较。广电运营商需综合考虑投...介绍了一种新的宽带接入技术DOL(DOCSIS over LAN),作为网络带宽扩容技术方案的一种新选择,讲解了方案实现的原理、机房端设备DOLc、用户接入端设备DOL Modem的体系结构,以及该系统优缺点及扩容方案的成本比较。广电运营商需综合考虑投资收益、风险控制和技术路线等一系列因素后才能决定采用何种方案。展开更多
基金the Ministry of Science and Technology of China(2018YFA0507402)the National Natural Science Foundation of China(32000667)+5 种基金the Shanghai Science and Technology Innovation Action(21ZR1470600)the Youth Innovation Promotion Association of the Chinese Academy of Sciences(2022264)the National Natural Science Foundation of China(81771465 and 81930033)the Science and Technology Project of the Department of Education of Jiangxi Province(GJJ211248)the Division of Intramural Research,National Institute of Allergy and Infectious Diseases,National Institutes of Health(grant 1ZIA-Al-001169)the US-China Biomedical Collaborative Research Program(grant Al-129775).
文摘Group 2 innate lymphoid cells(ILC2s)are a category of heterogeneous cells that produce the cytokines IL-5 and IL-13,which mediate the type 2 immune response.However,specific drug targets on lung ILC2s have rarely been reported.Previous studies have shown that type 2 cytokines,such as IL-5 and IL-13,are related to depression.Here,we demonstrated the negative correlation between the depression-associated monoamine neurotransmitter serotonin and secretion of the cytokines IL-5 and IL-13 by ILC2s in individuals with depression.Interestingly,serotonin ameliorates papain-induced lung inflammation by suppressing ILC2 activation.Our data showed that the serotonin receptor HTR2A was highly expressed on ILC2s from mouse lungs and human PBMCs.Furthermore,an HTR2A selective agonist(DOI)impaired ILC2 activation and alleviated the type 2 immune response in vivo and in vitro.Mice with ILC2-specific depletion of HTR2A(Il5^(cre/+)·Htr2a^(flox/flox)mice)abolished the DOI-mediated inhibition of ILC2s in a papain-induced mouse model of inflammation.In conclusion,serotonin and DOI could restrict the type 2 lung immune response,indicating a potential treatment strategy for type 2 lung inflammation by targeting HTR2A on ST2+ILC2s.
文摘With the development of computer graphics, the three-dimensional (3D) visualization brings new technological revolution to the traditional cartography. Therefore, the topographic 3D-map emerges to adapt to this technological revolution, and the applications of topographic 3D-map are spread rapidly to other relevant fields due to its incomparable advantage. The researches on digital map and the construction of map database offer strong technical support and abundant data source for this new technology, so the research and development of topographic 3D-map will receive greater concern. The basic data of the topographic 3D-map are rooted mainly in digital map and its basic model is derived from digital elevation model (DEM) and 3D-models of other DEM-based geographic features. In view of the potential enormous data and the complexity of geographic features, the dynamic representation of geographic information becomes the focus of the research of topographic 3D-map and also the prerequisite condition of 3D query and analysis. In addition to the equipment of hardware that are restraining, to a certain extent, the 3D representation, the data organization structure of geographic information will be the core problem of research on 3D-map. Level of detail (LOD), space partitioning, dynamic object loading (DOL) and object culling are core technologies of the dynamic 3D representation. The object- selection, attribute-query and model-editing are important functions and interaction tools for users with 3D-maps provided by topographic 3D-map system, all of which are based on the data structure of the 3D-model. This paper discusses the basic theories, concepts and cardinal principles of topographic 3D-map, expounds the basic way to organize the scene hierarchy of topographic 3D-map based on the node mechanism and studies the dynamic representation technologies of topographic 3D-map based on LOD, space partitioning, DOL and object culling. Moreover, such interactive operation functions are explored, in this paper, as spatial q
文摘介绍了一种新的宽带接入技术DOL(DOCSIS over LAN),作为网络带宽扩容技术方案的一种新选择,讲解了方案实现的原理、机房端设备DOLc、用户接入端设备DOL Modem的体系结构,以及该系统优缺点及扩容方案的成本比较。广电运营商需综合考虑投资收益、风险控制和技术路线等一系列因素后才能决定采用何种方案。
