A contour-parallel offset （CPO） tool-path linking algorithm is derived without toolretractions and with the largest practicability. The concept of ＂tool-path loop tree＂ （TPL-tree） providing the information on th...A contour-parallel offset （CPO） tool-path linking algorithm is derived without toolretractions and with the largest practicability. The concept of ＂tool-path loop tree＂ （TPL-tree） providing the information on the parent/child relationships among the tool-path loops （TPLs） is presented. The direction, tool-path loop, leaf/branch, layer number, and the corresponding points of the TPL-tree are introduced. By defining TPL as a vector, and by traveling throughout the tree, a CPO tool-path without tool-retractions can be derived.展开更多
A revised concept for urban water metabolism （UWM） is presented in this study to address the inadequacies in current research on UWM and the problems associated with the traditional urban water metabolic process. Fe...A revised concept for urban water metabolism （UWM） is presented in this study to address the inadequacies in current research on UWM and the problems associated with the traditional urban water metabolic process. Feedback loops can be analyzed to increase the water environmental carrying capacity （WECC） of the new urban water metabolism system （UWMS） over that of a traditional UWMS. An analysis of the feedback loops of an UWMS was used to construct a system dynamics （SD） model for the system under a WECC restriction. Water metabolic processes were simulated for different scenarios using the Tongzhou District in Beijing as an example. The results for the newly developed UWM case showed that a water environment of Tongzhou District could support a population of 1.1926 × 106, an irrigation area of 375.521 km2, a livestock of 0.7732 × 106, and an industrial value added of ￥193.14 × 109 （i.e. about US$28.285 × 109） in 2020. A sensitivity analysis showed that the WECC could be improved to some extent by constructing new sewage treatment facilities or by expanding the current sewage treatment facilities, using reclaimed water and improving the water circulation system.展开更多
Aim: To study the changes in rheological properties, namely the parameters of the hysteresis loops and yield stress versus time for human semen after ejaculation. Methods: Ejaculates were obtained from volunteers and ...Aim: To study the changes in rheological properties, namely the parameters of the hysteresis loops and yield stress versus time for human semen after ejaculation. Methods: Ejaculates were obtained from volunteers and immediately put into the test cup of a Brookfield Programmable DV-11 Rheometer, by which the hysteresis loops and yield stress were determined. Results: (1) Yield stress values dropped down from more than 3000 mPa to 60 mPa in about 5 minutes after ejaculation; (2) The shape of the hysteresis loops of shear stress versus shear rate was changed from the counter-clockwise direction, that enclosed a large area, into the clockwise direction, that enclosed a very small area. Conclusion: Human ejaculate originally possesses semi-solid or visco-elastic body behavior and in 5 minutes after liquefaction, it becomes a thixotropic fluid or shearing thinning fluid with very low viscosity.展开更多
Aims:This review was developed to introduce the essential components and variants of structural equation modeling(SEM),synthesize the common issues in SEM applications,and share our views on SEM’s future in ecologica...Aims:This review was developed to introduce the essential components and variants of structural equation modeling(SEM),synthesize the common issues in SEM applications,and share our views on SEM’s future in ecological research.Methods:We searched the Web of Science on SEM applications in ecological studies from 1999 through 2016 and summarized the potential of SEMs,with a special focus on unexplored uses in ecology.We also analyzed and discussed the common issues with SEM applications in previous publications and presented our view for its future applications.Results:We searched and found 146 relevant publications on SEM applications in ecological studies.We found that five SEM variants had not commenly been applied in ecology,including the latent growth curve model,Bayesian SEM,partial least square SEM,hierarchical SEM,and variable/model selection.We identified ten common issues in SEM applications including strength of causal assumption,specification of feedback loops,selection of models and variables,identification of models,methods of estimation,explanation of latent variables,selection of fit indices,report of results,estimation of sample size,and the fit of model.Conclusions:In previous ecological studies,measurements of latent variables,explanations of model parameters,and reports of key statistics were commonly overlooked,while several advanced uses of SEM had been ignored overall.With the increasing availability of data,the use of SEM holds immense potential for ecologists in the future.展开更多
The compositional heterogeneity in high-entropy alloys(HEAs)has been reported to be an inherent en-tity,which significantly alters the mechanical properties of materials by tuning the variation of lattice resistance f...The compositional heterogeneity in high-entropy alloys(HEAs)has been reported to be an inherent en-tity,which significantly alters the mechanical properties of materials by tuning the variation of lattice resistance for dislocation motion.However,since the body-centered cubic(BCC)structure is not close-packed,the change of lattice resistance is less sensitive to the normal concentration wave compared to that in face-centered cubic(FCC)structured materials.In this work,we selected a refractory bcc HEAs TiZrNbTa for the matrix and added a small amount of Al to facilitate the special spinodal decomposition structure.In particular,(TiZrNbTa)98.5 Al 1.5 displayed a typical basket-weave fabric morphology of spinodal decomposition structure with a characteristic periodicity of∼8 nm and had an optimal combination of strength and ductility(the yield strength of 1123±9 MPa and ductility of∼20.7%±0.6%).It was de-termined that by doing in situ TEM mechanical testing,the plastic deformation was dominated by the formation and operation of dislocation loops which provided both edge and screw components of dislo-cations.The synergetic effect of the remarkable chemical heterogeneity created by the spinodal decompo-sition and the spreading lattice distortion in high entropy alloys is quite effective in tuning the mobility of different types of dislocations and facilitates dislocation interactions,enabling the combination of high strength and ductility.展开更多
AIM:To investigate the relationships among subtypes of gastroesophageal reflux disease(GERD)using narrow band imaging(NBI)magnifying endoscopy.METHODS:A reflux disease questionnaire was used to screen 120 patients rep...AIM:To investigate the relationships among subtypes of gastroesophageal reflux disease(GERD)using narrow band imaging(NBI)magnifying endoscopy.METHODS:A reflux disease questionnaire was used to screen 120 patients representing the three subtypes of GERD(n=40 for each subtypes):nonerosive reflux disease(NERD),reflux esophagitis(RE)and Barrett’s esophagus(BE).NBI magnifying endoscopic procedure was performed on the patients as well as on 40 healthy controls.The demographic and clinical characteristics,and NBI magnifying endoscopic features,were recorded and compared among the groups.Targeted biopsy and histopathological examination were conducted if there were any abnormalities.SPSS 18.0 software was used for all statistical analysis.RESULTS:Compared with healthy controls,a significantly higher proportion of GERD patients had increased number of intrapapillary capillary loops(IPCLs)(78.3%vs 20%,P<0.05),presence of microerosions(41.7%vs 0%,P<0.05),and a non-round pit pattern below the squamocolumnar junction(88.3%vs 30%,P<0.05).The maximum(228±4.8 vs 144±4.7,P<0.05),minimum(171±3.8 vs 103±4.4,P<0.05),and average(199±3.9 vs 119±3.9,P<0.05)numbers of IPCLs/field were also significantly greater in GERD patients.However,comparison among groups of the three subtypes showed no significant differences or any linear trend,except that microerosions were present in 60%of the RE patients,but in only 35%and 30%of the NERD and BE patients,respectively(P<0.05).CONCLUSION:Patients with GERD,irrespective of subtype,have similar micro changes in the distal esophagus.The three forms of the disease are probably independent of each other.展开更多
The evolution of dislocation loops in austenitic steels irradiated with Fe^(+)is investigated using cluster dynamics(CD)simulations by developing a CD model.The CD predictions are compared with experimental results in...The evolution of dislocation loops in austenitic steels irradiated with Fe^(+)is investigated using cluster dynamics(CD)simulations by developing a CD model.The CD predictions are compared with experimental results in the literature.The number density and average diameter of the dislocation loops obtained from the CD simulations are in good agreement with the experimental data obtained from transmission electron microscopy(TEM)observations of Fe~+-irradiated Solution Annealed 304,Cold Worked 316,and HR3 austenitic steels in the literature.The CD simulation results demonstrate that the diffusion of in-cascade interstitial clusters plays a major role in the dislocation loop density and dislocation loop growth;in particular,for the HR3 austenitic steel,the CD model has verified the effect of temperature on the density and size of the dislocation loops.展开更多
Plasma equilibrium reconstruction provides essential information for tokamak operation and physical analysis.An extensive and reliable set of magnetic diagnostics is required to obtain accurate plasma equilibrium.This...Plasma equilibrium reconstruction provides essential information for tokamak operation and physical analysis.An extensive and reliable set of magnetic diagnostics is required to obtain accurate plasma equilibrium.This study designs and optimizes the magnetic diagnostics layout for the reconstruction of the equilibrium of the plasma according to the scientific objectives,engineering design parameters,and limitations of the Chinese Fusion Engineering Test Reactor(CFETR).Based on the CFETR discharge simulation,magnetic measurement data are employed to reconstruct consistent plasma equilibrium parameters,and magnetic diagnostics'number and position are optimized by truncated Singular value decomposition,verifying the redundancy reliability of the magnetic diagnostics layout design.This provides a design solution for the layout of the magnetic diagnostics system required to control the plasma equilibrium of CFETR,and the developed design and optimization method can provide effective support to design magnetic diagnostics systems for future magnetic confinement fusion devices.展开更多
Kink oscillations,which are frequently observed in coronal loops and prominences,are often accompanied by extreme-ultraviolet(EUV)waves.However,much more needs to be explored regarding the causal relationships between...Kink oscillations,which are frequently observed in coronal loops and prominences,are often accompanied by extreme-ultraviolet(EUV)waves.However,much more needs to be explored regarding the causal relationships between kink oscillations and EUV waves.In this article,we report the simultaneous detection of kink oscillations and EUV waves that are both associated with an X2.1 flare on 2023 March 03(SOL2023-03-03T17:39).The kink oscillations,which are almost perpendicular to the axes of loop-like structures,are observed in three coronal loops and one prominence.One short loop shows in-phase oscillation within the same period of 5.2 min at three positions.This oscillation could be triggered by the pushing of an expanding loop and interpreted as the standing kink wave.Time lags are found between the kink oscillations of the short loop and two long loops,suggesting that the kink wave travels in different loops.The kink oscillations of one long loop and the prominence are possibly driven by the disturbance of the coronal mass ejection(CME),and that of another long loop might be attributed to the interaction of the EUV wave.The onset time of the kink oscillation of the short loop is nearly same as the beginning of an EUV wave.This fact demonstrates that they are almost simultaneous.The EUV wave is most likely excited by the expanding loop structure and shows two components.The leading component is a fast coronal wave,and the trailing one could be due to the stretching magnetic field lines.展开更多
Geothermal heating of bridge decks is a reliable and sustainable method for bridge de-icing that has been in-creasing in demand since conventional de-icing methods were proved to be environmentally hazardous.Previous ...Geothermal heating of bridge decks is a reliable and sustainable method for bridge de-icing that has been in-creasing in demand since conventional de-icing methods were proved to be environmentally hazardous.Previous research on geothermal heating of bridge decks relied on hydronic pipes embedded inside of bridge decks,which are confined to newly constructed bridges.For existing bridges,a newly devised method for external heating has been recently tested under limited laboratory conditions to determine its overall performance.This study explores laboratory heating tests of a concrete slab with a thickness representing a typical concrete bridge deck.This slab was equipped with a simulated geothermal bridge de-icing system and tested inside a freezer subjected to sub-freezing controlled conditions.Various winter scenarios were applied to the system to determine its heat-ing performance and how feasible it will be for the system to be transferred to the field.A prediction equation was developed to estimate the total energy reserves required to permit de-icing,and statistical analysis was performed and validated with test results.The slab surface heat flux was estimated to range from 27 W/m^(2) K to 73 W/m^(2) K from the heating test.The externally-heated deck can be designed with the developed prediction equation for snow melting.展开更多
Higher-order chromatin organization is essential for transcriptional regulation,genome stability maintenance,and other genome functions.Increasing evidence has revealed significant differences in 3D chromatin organiza...Higher-order chromatin organization is essential for transcriptional regulation,genome stability maintenance,and other genome functions.Increasing evidence has revealed significant differences in 3D chromatin organization between plants and animals.However,the extent,pattern,and rules of chromatin organization in plants are still unclear.In this study,we systematically identified and characterized long-range chromatin loops in the Arabidopsis 3D genome.We identified hundreds of long-range cis chromatin loops and found their anchor regions are closely associated with H3K27me3 epigenetic modifications.Furthermore,we demonstrated that these chromatin loops are dependent on Polycomb group(PcG)proteins,suggesting that the Polycomb repressive complex2(PRC2)complex is essential for establishing and maintaining these novel loops.Although most of these PcG-medicated chromatin loops are stable,many of these loops are tissue-specific or dynamically regulated by different treatments.Interestingly,tandemly arrayed gene clusters and metabolic gene clusters are enriched in anchor regions.Long-range H3K27me3-marked chromatin interactions are associated with the coregulation of specific gene clusters.Finally,we also identified H3K27me3-associated chromatin loops associated with gene clusters in Oryza sativa and Glycine max,indicating that these long-range chromatin loops are conserved in plants.Our results provide novel insights into genome evolution and transcriptional coregulation in plants.展开更多
Rock magnetic measurements of Nihewan sediments from Xujiayao section demonstrate that magnetite, hematite and maghemite are dominant remanent magnetization carriers. Monitoring the variations of magnetic susceptibili...Rock magnetic measurements of Nihewan sediments from Xujiayao section demonstrate that magnetite, hematite and maghemite are dominant remanent magnetization carriers. Monitoring the variations of magnetic susceptibility(MS) and saturating isothermal remanent magnetization(SIRM) at low temperature are the attractive ways of detecting the presence of magnetite, maghemitization and superparamagnetic grain sizes. Low-temperature MS investigations suggest that susceptibility enhancement for Xujiayao samples is mainly due to the remarkable presence of SD/MD magnetite to some degree though some magnetite grains have been partially oxidized at some depths. It is tentatively concluded that both SD/MD magnetite and hematite are of detrital origin and carry a characteristic remanent magnetization(ChRM), whereas maghemite can be attributed to be chemical origin, overprinting a reversed polarity component of Matuyama age.展开更多
Two models are established to reveal the underlying coercivity mechanism for SmCo/Fe films,where one model considers a transition layer between hard and soft layers,while the other model does not consider this layer.B...Two models are established to reveal the underlying coercivity mechanism for SmCo/Fe films,where one model considers a transition layer between hard and soft layers,while the other model does not consider this layer.Based on the two models,hysteresis loops,nucleation fields and coercivity are obtained by one-dimensional(1 D)and three-dimensional(3 D)micromagnetic methods.In particular,the calculated nucleation fields(H_N)and coercivity(H_C)match very well with the experimental data.It is found that the increase in the soft phase thickness(Ls)leads to a transition of the coercivity mechanism from nucleation to pinning.Such a pinning is inherently related to nucleation and has both attributes of traditional nucleation and pinning,called as a hybrid coercivity mechanism here.It is general for all hard/soft composites and can be extended to single-phased permanent magnets where defects are inevitable.展开更多
Fe-10 at.%Cr alloy was implanted with hydrogen ions at room temperature, followed by annealing at high temperatures.The annealing process made the defects develop into large dislocation loops. The nature of the disloc...Fe-10 at.%Cr alloy was implanted with hydrogen ions at room temperature, followed by annealing at high temperatures.The annealing process made the defects develop into large dislocation loops. The nature of the dislocation loops formed after annealing was studied by the evolution of loops under in situ electron irradiation in high-voltage electron microscope.It indicated that only interstitial-type loops were observed when annealed at 550 °C and below, but vacancy-type loops started to form at the temperature higher than 600 °C. According to the previous study of our group, the presence of chromium element made the formation temperature of vacancy-type loops higher than that in pure iron. The effect of alloying elements on the formation temperature of the vacancy-type loops was discussed.展开更多
Ever since gene targeting or specific modification of genome sequences in mice was achieved in the early 1980s,the reverse genetic approach of precise editing of any genomic locus has greatly accelerated biomedical re...Ever since gene targeting or specific modification of genome sequences in mice was achieved in the early 1980s,the reverse genetic approach of precise editing of any genomic locus has greatly accelerated biomedical research and biotechnology development.In particular,the recent development of the CRISPR/Cas9 system has greatly expedited genetic dissection of 3D genomes.CRISPR gene-editing outcomes result from targeted genome cleavage by ectopic bacterial Cas9 nuclease followed by presumed random ligations via the host double-strand break repair machineries.Recent studies revealed,however,that the CRISPR genomeediting system is precise and predictable because of cohesive Cas9 cleavage of targeting DNA.Here,we synthesize the current understanding of CRISPR DNA fragment-editing mechanisms and recent progress in predictable outcomes from precise genetic engineering of 3D genomes.Specifically,we first briefly describe historical genetic studies leading to CRISPR and 3D genome engineering.We then summarize different types of chromosomal rearrangements by DNA fragment editing.Finally,we review significant progress from precise ID gene editing toward predictable 3D genome engineering and synthetic biology.The exciting and rapid advances in this emerging field provide new opportunities and challenges to understand or digest 3D genomes.展开更多
The circadian clock temporally coordinates plant growth and metabolism in close synchronization with the diurnal and seasonal environmental changes. Research over the last decade has identified a number of clock compo...The circadian clock temporally coordinates plant growth and metabolism in close synchronization with the diurnal and seasonal environmental changes. Research over the last decade has identified a number of clock components and a variety of regulatory mechanisms responsible for the rhythmic oscillations in metabolic and physiological activities. At the core of the clock, transcriptional/translational feedback loops modulate the expression of a significant proportion of the genome. In this article, we briefly describe some of the very recent advances that have improved our understanding of clock organization and function in Arabidopsis thaliana. The new studies illustrate the role of clock protein complex for- mation on circadian gating of plant growth and identify alternative splicing as a new regulatory mechanism for clock function. Examination of key clock properties such as temperature compensation has also opened new avenues for func- tional research within the plant clockwork. The emerging connections between the circadian clock and metabolism, hor- mone signaling and response to biotic and abiotic stress also add new layers of complexity to the clock network and underscore the significance of the circadian clock regulating the daily life of plants.展开更多
文摘A contour-parallel offset （CPO） tool-path linking algorithm is derived without toolretractions and with the largest practicability. The concept of ＂tool-path loop tree＂ （TPL-tree） providing the information on the parent/child relationships among the tool-path loops （TPLs） is presented. The direction, tool-path loop, leaf/branch, layer number, and the corresponding points of the TPL-tree are introduced. By defining TPL as a vector, and by traveling throughout the tree, a CPO tool-path without tool-retractions can be derived.
文摘A revised concept for urban water metabolism （UWM） is presented in this study to address the inadequacies in current research on UWM and the problems associated with the traditional urban water metabolic process. Feedback loops can be analyzed to increase the water environmental carrying capacity （WECC） of the new urban water metabolism system （UWMS） over that of a traditional UWMS. An analysis of the feedback loops of an UWMS was used to construct a system dynamics （SD） model for the system under a WECC restriction. Water metabolic processes were simulated for different scenarios using the Tongzhou District in Beijing as an example. The results for the newly developed UWM case showed that a water environment of Tongzhou District could support a population of 1.1926 × 106, an irrigation area of 375.521 km2, a livestock of 0.7732 × 106, and an industrial value added of ￥193.14 × 109 （i.e. about US$28.285 × 109） in 2020. A sensitivity analysis showed that the WECC could be improved to some extent by constructing new sewage treatment facilities or by expanding the current sewage treatment facilities, using reclaimed water and improving the water circulation system.
文摘Aim: To study the changes in rheological properties, namely the parameters of the hysteresis loops and yield stress versus time for human semen after ejaculation. Methods: Ejaculates were obtained from volunteers and immediately put into the test cup of a Brookfield Programmable DV-11 Rheometer, by which the hysteresis loops and yield stress were determined. Results: (1) Yield stress values dropped down from more than 3000 mPa to 60 mPa in about 5 minutes after ejaculation; (2) The shape of the hysteresis loops of shear stress versus shear rate was changed from the counter-clockwise direction, that enclosed a large area, into the clockwise direction, that enclosed a very small area. Conclusion: Human ejaculate originally possesses semi-solid or visco-elastic body behavior and in 5 minutes after liquefaction, it becomes a thixotropic fluid or shearing thinning fluid with very low viscosity.
基金supported by the High Technology Research and Development Program of Jilin(20130204021GX)the Specialized Research Fund for Graduate Course Identification System Program(Jilin University)of China(450060523183)+2 种基金the National Natural Science Foundation of China(61520106008,U1564207,61503149)the Education Department of Jilin Province of China(2016430)the Graduate Innovation Fund of Jilin University(2016030)
基金supported by the Sustainable Energy Pathways(CHE)Program(#1230246)the Dynamics of Coupled Natural and Human Systems(CNH)Program(#1313761)of the US National Science Foundation(NSF)。
文摘Aims:This review was developed to introduce the essential components and variants of structural equation modeling(SEM),synthesize the common issues in SEM applications,and share our views on SEM’s future in ecological research.Methods:We searched the Web of Science on SEM applications in ecological studies from 1999 through 2016 and summarized the potential of SEMs,with a special focus on unexplored uses in ecology.We also analyzed and discussed the common issues with SEM applications in previous publications and presented our view for its future applications.Results:We searched and found 146 relevant publications on SEM applications in ecological studies.We found that five SEM variants had not commenly been applied in ecology,including the latent growth curve model,Bayesian SEM,partial least square SEM,hierarchical SEM,and variable/model selection.We identified ten common issues in SEM applications including strength of causal assumption,specification of feedback loops,selection of models and variables,identification of models,methods of estimation,explanation of latent variables,selection of fit indices,report of results,estimation of sample size,and the fit of model.Conclusions:In previous ecological studies,measurements of latent variables,explanations of model parameters,and reports of key statistics were commonly overlooked,while several advanced uses of SEM had been ignored overall.With the increasing availability of data,the use of SEM holds immense potential for ecologists in the future.
基金supported by the National Natu-ral Science Foundation of China(Nos.51871197,52171166,and U20A20231)the Higher Education Discipline Innovation Project(No.B16042)the National Key Research and Development Program of China(No.2017YFA0208200).
文摘The compositional heterogeneity in high-entropy alloys(HEAs)has been reported to be an inherent en-tity,which significantly alters the mechanical properties of materials by tuning the variation of lattice resistance for dislocation motion.However,since the body-centered cubic(BCC)structure is not close-packed,the change of lattice resistance is less sensitive to the normal concentration wave compared to that in face-centered cubic(FCC)structured materials.In this work,we selected a refractory bcc HEAs TiZrNbTa for the matrix and added a small amount of Al to facilitate the special spinodal decomposition structure.In particular,(TiZrNbTa)98.5 Al 1.5 displayed a typical basket-weave fabric morphology of spinodal decomposition structure with a characteristic periodicity of∼8 nm and had an optimal combination of strength and ductility(the yield strength of 1123±9 MPa and ductility of∼20.7%±0.6%).It was de-termined that by doing in situ TEM mechanical testing,the plastic deformation was dominated by the formation and operation of dislocation loops which provided both edge and screw components of dislo-cations.The synergetic effect of the remarkable chemical heterogeneity created by the spinodal decompo-sition and the spreading lattice distortion in high entropy alloys is quite effective in tuning the mobility of different types of dislocations and facilitates dislocation interactions,enabling the combination of high strength and ductility.
基金Supported by The Key Clinical Projects forAffiliated Hospitals of Ministry of Health of China[2007]-353
文摘AIM:To investigate the relationships among subtypes of gastroesophageal reflux disease(GERD)using narrow band imaging(NBI)magnifying endoscopy.METHODS:A reflux disease questionnaire was used to screen 120 patients representing the three subtypes of GERD(n=40 for each subtypes):nonerosive reflux disease(NERD),reflux esophagitis(RE)and Barrett’s esophagus(BE).NBI magnifying endoscopic procedure was performed on the patients as well as on 40 healthy controls.The demographic and clinical characteristics,and NBI magnifying endoscopic features,were recorded and compared among the groups.Targeted biopsy and histopathological examination were conducted if there were any abnormalities.SPSS 18.0 software was used for all statistical analysis.RESULTS:Compared with healthy controls,a significantly higher proportion of GERD patients had increased number of intrapapillary capillary loops(IPCLs)(78.3%vs 20%,P<0.05),presence of microerosions(41.7%vs 0%,P<0.05),and a non-round pit pattern below the squamocolumnar junction(88.3%vs 30%,P<0.05).The maximum(228±4.8 vs 144±4.7,P<0.05),minimum(171±3.8 vs 103±4.4,P<0.05),and average(199±3.9 vs 119±3.9,P<0.05)numbers of IPCLs/field were also significantly greater in GERD patients.However,comparison among groups of the three subtypes showed no significant differences or any linear trend,except that microerosions were present in 60%of the RE patients,but in only 35%and 30%of the NERD and BE patients,respectively(P<0.05).CONCLUSION:Patients with GERD,irrespective of subtype,have similar micro changes in the distal esophagus.The three forms of the disease are probably independent of each other.
基金supported by the National Natural Science Foundation of China(No.U1967212)the Fundamental Research Funds for the Central Universities(No.2021MS032)the Nuclear Materials Innovation Foundation(No.WDZC-2023-AW-0305)。
文摘The evolution of dislocation loops in austenitic steels irradiated with Fe^(+)is investigated using cluster dynamics(CD)simulations by developing a CD model.The CD predictions are compared with experimental results in the literature.The number density and average diameter of the dislocation loops obtained from the CD simulations are in good agreement with the experimental data obtained from transmission electron microscopy(TEM)observations of Fe~+-irradiated Solution Annealed 304,Cold Worked 316,and HR3 austenitic steels in the literature.The CD simulation results demonstrate that the diffusion of in-cascade interstitial clusters plays a major role in the dislocation loop density and dislocation loop growth;in particular,for the HR3 austenitic steel,the CD model has verified the effect of temperature on the density and size of the dislocation loops.
基金Project supported by the National MCF Energy Research and Development Program of China (Grant Nos.2022YFE03010002,2018YFE0302100,and 2018YFE0301105)the National Natural Science Foundation of China (Grant Nos.11875291,11805236,11905256,and 12075285)。
文摘Plasma equilibrium reconstruction provides essential information for tokamak operation and physical analysis.An extensive and reliable set of magnetic diagnostics is required to obtain accurate plasma equilibrium.This study designs and optimizes the magnetic diagnostics layout for the reconstruction of the equilibrium of the plasma according to the scientific objectives,engineering design parameters,and limitations of the Chinese Fusion Engineering Test Reactor(CFETR).Based on the CFETR discharge simulation,magnetic measurement data are employed to reconstruct consistent plasma equilibrium parameters,and magnetic diagnostics'number and position are optimized by truncated Singular value decomposition,verifying the redundancy reliability of the magnetic diagnostics layout design.This provides a design solution for the layout of the magnetic diagnostics system required to control the plasma equilibrium of CFETR,and the developed design and optimization method can provide effective support to design magnetic diagnostics systems for future magnetic confinement fusion devices.
基金supported by the National Key R&D Program of China 2021YFA1600502(Grant No.2021YFA1600500)the National Natural Science Foundation of China(Grant Nos.11973092,12073081,12003064+4 种基金12333009)supported by the Surface Project of Jiangsu Province(Grant No.BK20211402)Yunnan Key Laboratory of Solar Physics and Space Science(202205AG070009)(Grant No.YNSPCC202207)a collaborative project conducted by the National Astronomical Observatories of CAS,Peking University,Tongji University,Xi’an Institute of Optics and Precision Mechanics of CAS and the Innovation Academy for Microsatellites of CASsupported by the China National Space Administration(CNSA)。
文摘Kink oscillations,which are frequently observed in coronal loops and prominences,are often accompanied by extreme-ultraviolet(EUV)waves.However,much more needs to be explored regarding the causal relationships between kink oscillations and EUV waves.In this article,we report the simultaneous detection of kink oscillations and EUV waves that are both associated with an X2.1 flare on 2023 March 03(SOL2023-03-03T17:39).The kink oscillations,which are almost perpendicular to the axes of loop-like structures,are observed in three coronal loops and one prominence.One short loop shows in-phase oscillation within the same period of 5.2 min at three positions.This oscillation could be triggered by the pushing of an expanding loop and interpreted as the standing kink wave.Time lags are found between the kink oscillations of the short loop and two long loops,suggesting that the kink wave travels in different loops.The kink oscillations of one long loop and the prominence are possibly driven by the disturbance of the coronal mass ejection(CME),and that of another long loop might be attributed to the interaction of the EUV wave.The onset time of the kink oscillation of the short loop is nearly same as the beginning of an EUV wave.This fact demonstrates that they are almost simultaneous.The EUV wave is most likely excited by the expanding loop structure and shows two components.The leading component is a fast coronal wave,and the trailing one could be due to the stretching magnetic field lines.
基金the financial support and guidance provided for this study by the Texas Department of Transportation(TxDOT).
文摘Geothermal heating of bridge decks is a reliable and sustainable method for bridge de-icing that has been in-creasing in demand since conventional de-icing methods were proved to be environmentally hazardous.Previous research on geothermal heating of bridge decks relied on hydronic pipes embedded inside of bridge decks,which are confined to newly constructed bridges.For existing bridges,a newly devised method for external heating has been recently tested under limited laboratory conditions to determine its overall performance.This study explores laboratory heating tests of a concrete slab with a thickness representing a typical concrete bridge deck.This slab was equipped with a simulated geothermal bridge de-icing system and tested inside a freezer subjected to sub-freezing controlled conditions.Various winter scenarios were applied to the system to determine its heat-ing performance and how feasible it will be for the system to be transferred to the field.A prediction equation was developed to estimate the total energy reserves required to permit de-icing,and statistical analysis was performed and validated with test results.The slab surface heat flux was estimated to range from 27 W/m^(2) K to 73 W/m^(2) K from the heating test.The externally-heated deck can be designed with the developed prediction equation for snow melting.
基金supported by the National Natural Science Foundation of China(31970614 and 32270288 to W.Q.)Director’s Award of Peking University Institute of Advanced Agricultural Sciences,Shandong Development Fund of Science&TechnologyAward of Natural Science Foundation of Shandong Province(ZR2021ZD30)。
文摘Higher-order chromatin organization is essential for transcriptional regulation,genome stability maintenance,and other genome functions.Increasing evidence has revealed significant differences in 3D chromatin organization between plants and animals.However,the extent,pattern,and rules of chromatin organization in plants are still unclear.In this study,we systematically identified and characterized long-range chromatin loops in the Arabidopsis 3D genome.We identified hundreds of long-range cis chromatin loops and found their anchor regions are closely associated with H3K27me3 epigenetic modifications.Furthermore,we demonstrated that these chromatin loops are dependent on Polycomb group(PcG)proteins,suggesting that the Polycomb repressive complex2(PRC2)complex is essential for establishing and maintaining these novel loops.Although most of these PcG-medicated chromatin loops are stable,many of these loops are tissue-specific or dynamically regulated by different treatments.Interestingly,tandemly arrayed gene clusters and metabolic gene clusters are enriched in anchor regions.Long-range H3K27me3-marked chromatin interactions are associated with the coregulation of specific gene clusters.Finally,we also identified H3K27me3-associated chromatin loops associated with gene clusters in Oryza sativa and Glycine max,indicating that these long-range chromatin loops are conserved in plants.Our results provide novel insights into genome evolution and transcriptional coregulation in plants.
基金This work was supported by the National Natural Science Foundation of China (Grant No.49474218) The Norwegian MSc-Program financed the stay of Wang Xisheng in Norway for two years. We thank Dr. Harald Walderhaug, Dr. H. Stockhausen, and Dr. F. Hauge
文摘Rock magnetic measurements of Nihewan sediments from Xujiayao section demonstrate that magnetite, hematite and maghemite are dominant remanent magnetization carriers. Monitoring the variations of magnetic susceptibility(MS) and saturating isothermal remanent magnetization(SIRM) at low temperature are the attractive ways of detecting the presence of magnetite, maghemitization and superparamagnetic grain sizes. Low-temperature MS investigations suggest that susceptibility enhancement for Xujiayao samples is mainly due to the remarkable presence of SD/MD magnetite to some degree though some magnetite grains have been partially oxidized at some depths. It is tentatively concluded that both SD/MD magnetite and hematite are of detrital origin and carry a characteristic remanent magnetization(ChRM), whereas maghemite can be attributed to be chemical origin, overprinting a reversed polarity component of Matuyama age.
基金financially supported by the National Natural Science Foundation of China(Nos.51771127,51571126 and 51772004).
文摘Two models are established to reveal the underlying coercivity mechanism for SmCo/Fe films,where one model considers a transition layer between hard and soft layers,while the other model does not consider this layer.Based on the two models,hysteresis loops,nucleation fields and coercivity are obtained by one-dimensional(1 D)and three-dimensional(3 D)micromagnetic methods.In particular,the calculated nucleation fields(H_N)and coercivity(H_C)match very well with the experimental data.It is found that the increase in the soft phase thickness(Ls)leads to a transition of the coercivity mechanism from nucleation to pinning.Such a pinning is inherently related to nucleation and has both attributes of traditional nucleation and pinning,called as a hybrid coercivity mechanism here.It is general for all hard/soft composites and can be extended to single-phased permanent magnets where defects are inevitable.
基金supported by the National Natural Science Foundation of China (Grant No. 51471026)
文摘Fe-10 at.%Cr alloy was implanted with hydrogen ions at room temperature, followed by annealing at high temperatures.The annealing process made the defects develop into large dislocation loops. The nature of the dislocation loops formed after annealing was studied by the evolution of loops under in situ electron irradiation in high-voltage electron microscope.It indicated that only interstitial-type loops were observed when annealed at 550 °C and below, but vacancy-type loops started to form at the temperature higher than 600 °C. According to the previous study of our group, the presence of chromium element made the formation temperature of vacancy-type loops higher than that in pure iron. The effect of alloying elements on the formation temperature of the vacancy-type loops was discussed.
基金This work was supported by grants from the National Natural Science Foundation of China(31630039 and 32000425)the Ministry of Science and Technology of China(2017YFA0504203 and 2018YFC1004504)the Science and Technology Commission of Shanghai Municipality(19JC1412500).
文摘Ever since gene targeting or specific modification of genome sequences in mice was achieved in the early 1980s,the reverse genetic approach of precise editing of any genomic locus has greatly accelerated biomedical research and biotechnology development.In particular,the recent development of the CRISPR/Cas9 system has greatly expedited genetic dissection of 3D genomes.CRISPR gene-editing outcomes result from targeted genome cleavage by ectopic bacterial Cas9 nuclease followed by presumed random ligations via the host double-strand break repair machineries.Recent studies revealed,however,that the CRISPR genomeediting system is precise and predictable because of cohesive Cas9 cleavage of targeting DNA.Here,we synthesize the current understanding of CRISPR DNA fragment-editing mechanisms and recent progress in predictable outcomes from precise genetic engineering of 3D genomes.Specifically,we first briefly describe historical genetic studies leading to CRISPR and 3D genome engineering.We then summarize different types of chromosomal rearrangements by DNA fragment editing.Finally,we review significant progress from precise ID gene editing toward predictable 3D genome engineering and synthetic biology.The exciting and rapid advances in this emerging field provide new opportunities and challenges to understand or digest 3D genomes.
文摘The circadian clock temporally coordinates plant growth and metabolism in close synchronization with the diurnal and seasonal environmental changes. Research over the last decade has identified a number of clock components and a variety of regulatory mechanisms responsible for the rhythmic oscillations in metabolic and physiological activities. At the core of the clock, transcriptional/translational feedback loops modulate the expression of a significant proportion of the genome. In this article, we briefly describe some of the very recent advances that have improved our understanding of clock organization and function in Arabidopsis thaliana. The new studies illustrate the role of clock protein complex for- mation on circadian gating of plant growth and identify alternative splicing as a new regulatory mechanism for clock function. Examination of key clock properties such as temperature compensation has also opened new avenues for func- tional research within the plant clockwork. The emerging connections between the circadian clock and metabolism, hor- mone signaling and response to biotic and abiotic stress also add new layers of complexity to the clock network and underscore the significance of the circadian clock regulating the daily life of plants.
