The role of alcohol in causing or aggravating the pathogenesis of inflammatory bowel disease is unclear.For finding a conclusive answer for this valuable question we conducted this review.Only two studies were identif...The role of alcohol in causing or aggravating the pathogenesis of inflammatory bowel disease is unclear.For finding a conclusive answer for this valuable question we conducted this review.Only two studies were identified that successfully fulfilled our inclusive criteria.Usual consumption of alcohol reduced the risk compared with less frequent use(odds ratio = 0.57,95%CI:0.37-0.86).Light alcoholic drinking has protective effects against development of ulcerative colitis.But this inverse association disappeared when smoking was included.展开更多
Crohn's disease (CD), a variant of chronic inflammatory bowel disease, frequently affects the terminal ileum and coecal region. The clinical symptoms are often subtle and depend on the inflammatory activity of dis...Crohn's disease (CD), a variant of chronic inflammatory bowel disease, frequently affects the terminal ileum and coecal region. The clinical symptoms are often subtle and depend on the inflammatory activity of disease. In women of child-bearing age, florid intestinal endometriosis can simulate CD. Moreover, current pathophysiological concepts include intestinal endometriosis as a putative founder lesion for consecutive CD establishment. The report summarizes clinical and histomorphological data of a 35-year-old woman with the rare coincidence of florid intestinal endometriosis and CD both affecting the terminal ileum. The patient was suffering over 10 years from strong abdominal disorders including constipation, diarrhea, weight loss, and diffuse abdominal pain. In magnetic resonance imaging-Sellink, strong inflammation and intestinal obstruction of the terminal ileum were found. The laparoscopy revealed further evidence for existence of an inflammatory disease like CD, but brownish spots on the peritoneum were found indicative for endometriosis. Surgical resection of the terminal ileum and the coecal segment was performed followed by histopathological investigations. In transmural sections of the terminal ileum, histomorphological features of florid endometriosis intermingled with florid CD was found. The diagnostic findings were substantiated with a panel of immunohistological stainings. In conclusion, the findings demonstrate that florid endometriosis persists in florid CD lesions and the putative link between intestinal endometriosis and CD is more complex than previously assumed.展开更多
文摘The role of alcohol in causing or aggravating the pathogenesis of inflammatory bowel disease is unclear.For finding a conclusive answer for this valuable question we conducted this review.Only two studies were identified that successfully fulfilled our inclusive criteria.Usual consumption of alcohol reduced the risk compared with less frequent use(odds ratio = 0.57,95%CI:0.37-0.86).Light alcoholic drinking has protective effects against development of ulcerative colitis.But this inverse association disappeared when smoking was included.
基金Supported by The Rotationsprogramm of the Medical Faculty RWTH Aachen to Kaemmerer E
文摘Crohn's disease (CD), a variant of chronic inflammatory bowel disease, frequently affects the terminal ileum and coecal region. The clinical symptoms are often subtle and depend on the inflammatory activity of disease. In women of child-bearing age, florid intestinal endometriosis can simulate CD. Moreover, current pathophysiological concepts include intestinal endometriosis as a putative founder lesion for consecutive CD establishment. The report summarizes clinical and histomorphological data of a 35-year-old woman with the rare coincidence of florid intestinal endometriosis and CD both affecting the terminal ileum. The patient was suffering over 10 years from strong abdominal disorders including constipation, diarrhea, weight loss, and diffuse abdominal pain. In magnetic resonance imaging-Sellink, strong inflammation and intestinal obstruction of the terminal ileum were found. The laparoscopy revealed further evidence for existence of an inflammatory disease like CD, but brownish spots on the peritoneum were found indicative for endometriosis. Surgical resection of the terminal ileum and the coecal segment was performed followed by histopathological investigations. In transmural sections of the terminal ileum, histomorphological features of florid endometriosis intermingled with florid CD was found. The diagnostic findings were substantiated with a panel of immunohistological stainings. In conclusion, the findings demonstrate that florid endometriosis persists in florid CD lesions and the putative link between intestinal endometriosis and CD is more complex than previously assumed.
