目的探究牛肺表面活性剂联合高频振荡通气(high frequency oscillatory ventilation,HFOV)与牛肺表面活性剂联合常频通气对新生儿呼吸窘迫综合征血气指数及安全性的影响。方法收集2019年1月1日—2020年9月30日在本院出生并确诊为呼吸窘...目的探究牛肺表面活性剂联合高频振荡通气(high frequency oscillatory ventilation,HFOV)与牛肺表面活性剂联合常频通气对新生儿呼吸窘迫综合征血气指数及安全性的影响。方法收集2019年1月1日—2020年9月30日在本院出生并确诊为呼吸窘迫综合征的新生儿100例,不限性别。随机将其分为牛肺表面活性剂联合高频震荡通气治疗组(高频组)和牛肺表面活性剂联合常频通气(常频组),每组50例。观察两组新生儿治疗近期各时段的二氧化碳分压(partial pressure of carbon dioxide,PaCO2)和氧合指数(oxygenation index,OI),机械通气时间、氧暴露时间,治疗后并发症发生率。结果高频组治疗后2 h,12 h,24 h OI及PaCO2均低于常频组,比较差异均有统计学意义(P<0.05);高频组机械通气时间(无创及有创)、氧暴露时间均低于常频组,比较差异均有统计学意义(P<0.05);两组患儿病死率比较无统计学意义(P>0.05);两组患儿并发症比较发现,高频组支气管肺发育不良(bronchopulmonary dysplasia,BPD)、脑室内出血(intraventricular hemorrhage,IVH)发生率(0%、0%)与常频组(4.00%、0%)比较差异无统计学意义(P>0.05),脑室周围白质软化(periventricular leukomalacia,PVL)、肺气漏发生率(0%、2.00%)均低于常频组(14.00%、16.00%),差异均有统计学意义(P<0.05)。结论HFOV联合牛肺表面活性剂较常频通气联合牛肺表面活性剂在血气指数、机械通气时间方面均存在优势,并在减少BPD和肺气漏发生方面更具有显著作用。展开更多
The mixed micelle formation of binary cationic 14-s-14 gemini with conventional single chain surfactants was studied by conductivity measurements.The critical micelle concentration(cmc) and the degree of counterion bi...The mixed micelle formation of binary cationic 14-s-14 gemini with conventional single chain surfactants was studied by conductivity measurements.The critical micelle concentration(cmc) and the degree of counterion binding values(g) of the binary systems were determined.The results were analyzed by applying regular solution theory(RST) to calculate micellar compositions(X),activity coefficients(f1,f2),and the interaction parameters(β).The synergistic interactions of all the investigated cationic gemini+conventional surfactant combinations were found to be dependent upon the length of hydrophobic spacer of the gemini surfactant.The excess Gibbs free energy of mixing was evaluated,and it indicated relatively more stable mixed micelles for the binary combinations.展开更多
用表面张力法研究了阳离子gemini表面活性剂乙基-1,2-双(十二烷基二甲基溴化铵)(简写为12-2-12)和非离子表面活性剂十二烷基聚氧乙烯醚(C_(12)E_n,其中n=4,10,23)混合体系在气液界面上的吸附行为;用扩张流变技术研究了吸附膜的扩张粘弹...用表面张力法研究了阳离子gemini表面活性剂乙基-1,2-双(十二烷基二甲基溴化铵)(简写为12-2-12)和非离子表面活性剂十二烷基聚氧乙烯醚(C_(12)E_n,其中n=4,10,23)混合体系在气液界面上的吸附行为;用扩张流变技术研究了吸附膜的扩张粘弹行为,实验数据用Lucassen-van den Tempel(LVT)模型进行拟合并根据模型得到了极限弹性值.最后研究了混合体系的泡沫行为,用泡沫塌陷到初始高度一半所对应的时间(t_(1/2))来表征泡沫的稳定性.结果表明,所有的非离子表面活性剂C_(12)E_n均与12-2-12产生了吸引作用.在12-2-12浓度相同的情况下,混合吸附层中吸附分子的最小分子占据面积的顺序为12-2-12/C_(12)E_(23)>12-2-12/C_(12)E_(10)>12-2-12/C_(12)E_4,而极限弹性的顺序为ε_(0,fit)(12-2-12/C_(12)E_4)>ε_(0,fit)(12-2-12/C_(12)E_(10))>ε_(0,fit)(12-2-12/C_(12)E_(23)).与单组分12-2-12形成的吸附膜相比,只有12-2-12/C_(12)E_4形成更加紧密的结构.具有较小亲水头基的非离子表面活性剂C_(12)E_4的加入可增强12-2-12吸附膜的弹性,进而增强了对应体系泡沫的稳定性.展开更多
基金supported by the Council of Scientific and Industrial Research(CSIR) Funds,New Delhi,India(ACK.No.:123075/2K8/1)
文摘The mixed micelle formation of binary cationic 14-s-14 gemini with conventional single chain surfactants was studied by conductivity measurements.The critical micelle concentration(cmc) and the degree of counterion binding values(g) of the binary systems were determined.The results were analyzed by applying regular solution theory(RST) to calculate micellar compositions(X),activity coefficients(f1,f2),and the interaction parameters(β).The synergistic interactions of all the investigated cationic gemini+conventional surfactant combinations were found to be dependent upon the length of hydrophobic spacer of the gemini surfactant.The excess Gibbs free energy of mixing was evaluated,and it indicated relatively more stable mixed micelles for the binary combinations.
基金supported by the National Natural Science Foundation of China(21473032,21273040)~~
文摘用表面张力法研究了阳离子gemini表面活性剂乙基-1,2-双(十二烷基二甲基溴化铵)(简写为12-2-12)和非离子表面活性剂十二烷基聚氧乙烯醚(C_(12)E_n,其中n=4,10,23)混合体系在气液界面上的吸附行为;用扩张流变技术研究了吸附膜的扩张粘弹行为,实验数据用Lucassen-van den Tempel(LVT)模型进行拟合并根据模型得到了极限弹性值.最后研究了混合体系的泡沫行为,用泡沫塌陷到初始高度一半所对应的时间(t_(1/2))来表征泡沫的稳定性.结果表明,所有的非离子表面活性剂C_(12)E_n均与12-2-12产生了吸引作用.在12-2-12浓度相同的情况下,混合吸附层中吸附分子的最小分子占据面积的顺序为12-2-12/C_(12)E_(23)>12-2-12/C_(12)E_(10)>12-2-12/C_(12)E_4,而极限弹性的顺序为ε_(0,fit)(12-2-12/C_(12)E_4)>ε_(0,fit)(12-2-12/C_(12)E_(10))>ε_(0,fit)(12-2-12/C_(12)E_(23)).与单组分12-2-12形成的吸附膜相比,只有12-2-12/C_(12)E_4形成更加紧密的结构.具有较小亲水头基的非离子表面活性剂C_(12)E_4的加入可增强12-2-12吸附膜的弹性,进而增强了对应体系泡沫的稳定性.
