An attempt was made to combine molecular imprinting technique and the electropolymerization of self-assembled o-amino thiophenol（o-AT） to prepare imprinted film using cinchonine as the model template analyte. The pr...An attempt was made to combine molecular imprinting technique and the electropolymerization of self-assembled o-amino thiophenol（o-AT） to prepare imprinted film using cinchonine as the model template analyte. The procedure of forming recognition cavity and the effect of the ratio of monomers to templates on the imprinted film, together with sensitivity and selectivity to cinchonine on the imprinted electrode, were demonstrated. An indirect and rapid detection was carried out using potassium ferricyande as a probe. Stable response is achieved within 4 min, covering a linear range (5.0×10-6\)4.0×10-5 mol/L. From the results, the main driving force for recognition is supposed to be hydrophobic interaction, complementary cavity effect and phenyl group for π-π interactions with the enaphthyl residue.展开更多
（S）-（1-Benzylpyrrolidin-2-yl）diphenylmethanol and cinchonine were evaluated as promotors in the asymmetric additions of phenylacetylene to ketones, in order to prepare chiral propargylic alcohols. Good yields （up...（S）-（1-Benzylpyrrolidin-2-yl）diphenylmethanol and cinchonine were evaluated as promotors in the asymmetric additions of phenylacetylene to ketones, in order to prepare chiral propargylic alcohols. Good yields （up to 89%） and moderate enantioselectivities （up to 77.9% ee） were achieved. Addition of Ti（OPr-i）4 can significantly improve the enantioselectivity of the reaction.展开更多
The reaction of CuI with cinchonine （an organic donor-acceptor chromophore） afforded a homochiral 3D diamondoid network [Cu4I4（cinchonine）2]n （1） containing a cubane cluster （Cu4I4） as a connecting node. This ...The reaction of CuI with cinchonine （an organic donor-acceptor chromophore） afforded a homochiral 3D diamondoid network [Cu4I4（cinchonine）2]n （1） containing a cubane cluster （Cu4I4） as a connecting node. This is the first homochiral coordination polymer with diamondoid nets containing a cluster as a connecting note. Its thermal stability and solid state optical properties such as fluorescence, circular dichroism and second-harmonic generation response were also reported.展开更多
Cinchonine alkaloid catalyzed enantioselective methanolysis of six 4-substituted 2-phenyl-5(4H)-oxazolones to (S)-methyl N-benzoyl-alpha-amino acid esters with 10-33% e.e and 72-81% yield.
A possibility of preparation of enantiomerically pure 1,1' bi 2 naphthols using an impure cinchonine has been examined. The solid and the mother liquor formed from the reaction of 1,1' bi 2 naphtholbori...A possibility of preparation of enantiomerically pure 1,1' bi 2 naphthols using an impure cinchonine has been examined. The solid and the mother liquor formed from the reaction of 1,1' bi 2 naphtholboric anhydride and 85 % cinchonine in toluene could give optically pure (S) ( ) and (R) (+) 1,1' bi 2 naphthol after acidification and kinetic crystallization, the overall yields were 40 % and 28 %, respectively.展开更多
利用金电极为工作电极,研究了辛可宁-Ru（bpy）3^2＋体系的电致化学发光行为。研究表明,辛可宁对Ru（bpy）3^2＋在电极表面的电致化学发光具有显著的增强作用,据此建立了一种高灵敏度测定辛可宁的电致化学发光分析方法。考察了硼酸-硼...利用金电极为工作电极,研究了辛可宁-Ru（bpy）3^2＋体系的电致化学发光行为。研究表明,辛可宁对Ru（bpy）3^2＋在电极表面的电致化学发光具有显著的增强作用,据此建立了一种高灵敏度测定辛可宁的电致化学发光分析方法。考察了硼酸-硼砂缓冲溶液的浓度、p H值、联吡啶钌浓度、光电倍增管电压等参数对实验的影响。在12 mmol/L硼酸-硼砂缓冲溶液（p H 9.0）中,辛可宁浓度的对数lgc在3.0×10^-9-6.0×10^-6mol/L范围内与Ru（bpy）2＋3的电致化学发光强度变化值（ΔI）呈线性关系,检出限（S/N=3）为1.76×10^-10mol/L。应用此法对血清中辛可宁的浓度进行测试,加标回收率为102.1%-109.5%。展开更多
文摘An attempt was made to combine molecular imprinting technique and the electropolymerization of self-assembled o-amino thiophenol（o-AT） to prepare imprinted film using cinchonine as the model template analyte. The procedure of forming recognition cavity and the effect of the ratio of monomers to templates on the imprinted film, together with sensitivity and selectivity to cinchonine on the imprinted electrode, were demonstrated. An indirect and rapid detection was carried out using potassium ferricyande as a probe. Stable response is achieved within 4 min, covering a linear range (5.0×10-6\)4.0×10-5 mol/L. From the results, the main driving force for recognition is supposed to be hydrophobic interaction, complementary cavity effect and phenyl group for π-π interactions with the enaphthyl residue.
文摘（S）-（1-Benzylpyrrolidin-2-yl）diphenylmethanol and cinchonine were evaluated as promotors in the asymmetric additions of phenylacetylene to ketones, in order to prepare chiral propargylic alcohols. Good yields （up to 89%） and moderate enantioselectivities （up to 77.9% ee） were achieved. Addition of Ti（OPr-i）4 can significantly improve the enantioselectivity of the reaction.
基金Project supported by 973 project （No. 2025103）, the National Natural Science Foundation of China （No. 2003028400） and the Distinguished Young Scholar Fund from the National Natural Science Foundation of China （No. 2006CB806104）.
文摘The reaction of CuI with cinchonine （an organic donor-acceptor chromophore） afforded a homochiral 3D diamondoid network [Cu4I4（cinchonine）2]n （1） containing a cubane cluster （Cu4I4） as a connecting node. This is the first homochiral coordination polymer with diamondoid nets containing a cluster as a connecting note. Its thermal stability and solid state optical properties such as fluorescence, circular dichroism and second-harmonic generation response were also reported.
文摘Cinchonine alkaloid catalyzed enantioselective methanolysis of six 4-substituted 2-phenyl-5(4H)-oxazolones to (S)-methyl N-benzoyl-alpha-amino acid esters with 10-33% e.e and 72-81% yield.
文摘A possibility of preparation of enantiomerically pure 1,1' bi 2 naphthols using an impure cinchonine has been examined. The solid and the mother liquor formed from the reaction of 1,1' bi 2 naphtholboric anhydride and 85 % cinchonine in toluene could give optically pure (S) ( ) and (R) (+) 1,1' bi 2 naphthol after acidification and kinetic crystallization, the overall yields were 40 % and 28 %, respectively.
文摘利用金电极为工作电极,研究了辛可宁-Ru（bpy）3^2＋体系的电致化学发光行为。研究表明,辛可宁对Ru（bpy）3^2＋在电极表面的电致化学发光具有显著的增强作用,据此建立了一种高灵敏度测定辛可宁的电致化学发光分析方法。考察了硼酸-硼砂缓冲溶液的浓度、p H值、联吡啶钌浓度、光电倍增管电压等参数对实验的影响。在12 mmol/L硼酸-硼砂缓冲溶液（p H 9.0）中,辛可宁浓度的对数lgc在3.0×10^-9-6.0×10^-6mol/L范围内与Ru（bpy）2＋3的电致化学发光强度变化值（ΔI）呈线性关系,检出限（S/N=3）为1.76×10^-10mol/L。应用此法对血清中辛可宁的浓度进行测试,加标回收率为102.1%-109.5%。
