The dose rate effect of radiation genetics has been studied intensively because of its practical as well as theoretical importance. According to the classical theory of radiation genetics, the dose-response curve for ...The dose rate effect of radiation genetics has been studied intensively because of its practical as well as theoretical importance. According to the classical theory of radiation genetics, the dose-response curve for one-hit chromosome aberrations is linear and independent of the intensity or dose rate of radiation. In the case of two-hit aberrations, the frequency of aberrations increases as the square of the dose. Newcombe postulated that a break in a chromosome may restitute in a given period of time. The phenomena of chromosomal restitution or of the existence of a rejoining system were further confirmed by Wolff et al. If restitution in the first break occurs before the formation of a second break, chromosome aberration of the rearrangement type is no longer possible.展开更多
文摘The dose rate effect of radiation genetics has been studied intensively because of its practical as well as theoretical importance. According to the classical theory of radiation genetics, the dose-response curve for one-hit chromosome aberrations is linear and independent of the intensity or dose rate of radiation. In the case of two-hit aberrations, the frequency of aberrations increases as the square of the dose. Newcombe postulated that a break in a chromosome may restitute in a given period of time. The phenomena of chromosomal restitution or of the existence of a rejoining system were further confirmed by Wolff et al. If restitution in the first break occurs before the formation of a second break, chromosome aberration of the rearrangement type is no longer possible.
