Lycium barbarum is a widely used Chinese herbal medicine prescription for protection of optic nerve.However,it remains unclear regarding the effects of Lycium barbarum polysaccharides,the main component of Lycium barb...Lycium barbarum is a widely used Chinese herbal medicine prescription for protection of optic nerve.However,it remains unclear regarding the effects of Lycium barbarum polysaccharides,the main component of Lycium barbarum,on in vivo proliferation of adult ciliary body cells.In this study,adult rats were intragastrically administered low-and high-dose Lycium barbarum polysaccharides（1 and 10 mg/kg）for 35 days and those intragastrically administered phosphate buffered saline served as controls.The number of Ki-67-positive cells in rat ciliary body in the Lycium barbarum polysaccharides groups,in particular low-dose Lycium barbarum polysaccharides group,was significantly greater than that in the phosphate buffered saline group.Ki-67-positive rat ciliary body cells expressed nestin but they did not express glial fibrillary acidic protein.These findings suggest that Lycium barbarum polysaccharides can promote the proliferation of adult rat retinal progenitor cells and the proliferated cells present with neuronal phenotype.展开更多
目前,对中药调节肺癌免疫的研究侧重于药物成分和复方研究两方面。中药提取物可通过不同途径作用于天然免疫和适应性免疫系统,其中的多糖类物质多被认为是中药发挥免疫调节功能的主要成分,传统补益类药物中的多糖如黄芪多糖、红景天多...目前,对中药调节肺癌免疫的研究侧重于药物成分和复方研究两方面。中药提取物可通过不同途径作用于天然免疫和适应性免疫系统,其中的多糖类物质多被认为是中药发挥免疫调节功能的主要成分,传统补益类药物中的多糖如黄芪多糖、红景天多糖、灵芝多糖等,调节免疫功能的作用较为突出,可通过提高树突状细胞(dendritic cells,DC)等抗原提呈细胞的数量,促进其表面细胞因子的表达,加强抗原提呈能力,增强机体免疫,还可刺激T细胞分化,提高细胞毒性T淋巴细胞(cytotoxic T lymphocyte,CTL)的免疫应答,加强对肿瘤细胞的清除,改善免疫抑制状态,抑制肿瘤细胞的生长。而经过配伍的中药复方具有活性物质群,可同时作用于多个靶点,呈现多效性。中药在肺癌的免疫治疗方面具有良好前景,但是中药成分复杂,临床应用讲究辨证论治,需努力寻求与现代医学之间的平衡,以促进中医药科研的标准化、客观化。展开更多
文摘Lycium barbarum is a widely used Chinese herbal medicine prescription for protection of optic nerve.However,it remains unclear regarding the effects of Lycium barbarum polysaccharides,the main component of Lycium barbarum,on in vivo proliferation of adult ciliary body cells.In this study,adult rats were intragastrically administered low-and high-dose Lycium barbarum polysaccharides（1 and 10 mg/kg）for 35 days and those intragastrically administered phosphate buffered saline served as controls.The number of Ki-67-positive cells in rat ciliary body in the Lycium barbarum polysaccharides groups,in particular low-dose Lycium barbarum polysaccharides group,was significantly greater than that in the phosphate buffered saline group.Ki-67-positive rat ciliary body cells expressed nestin but they did not express glial fibrillary acidic protein.These findings suggest that Lycium barbarum polysaccharides can promote the proliferation of adult rat retinal progenitor cells and the proliferated cells present with neuronal phenotype.
文摘目前,对中药调节肺癌免疫的研究侧重于药物成分和复方研究两方面。中药提取物可通过不同途径作用于天然免疫和适应性免疫系统,其中的多糖类物质多被认为是中药发挥免疫调节功能的主要成分,传统补益类药物中的多糖如黄芪多糖、红景天多糖、灵芝多糖等,调节免疫功能的作用较为突出,可通过提高树突状细胞(dendritic cells,DC)等抗原提呈细胞的数量,促进其表面细胞因子的表达,加强抗原提呈能力,增强机体免疫,还可刺激T细胞分化,提高细胞毒性T淋巴细胞(cytotoxic T lymphocyte,CTL)的免疫应答,加强对肿瘤细胞的清除,改善免疫抑制状态,抑制肿瘤细胞的生长。而经过配伍的中药复方具有活性物质群,可同时作用于多个靶点,呈现多效性。中药在肺癌的免疫治疗方面具有良好前景,但是中药成分复杂,临床应用讲究辨证论治,需努力寻求与现代医学之间的平衡,以促进中医药科研的标准化、客观化。
