目的探讨一期前后联合入路内固定治疗颈椎多节段骨折脱位。方法对1997至2003年9例同时伴有颈椎前后柱损伤的颈椎多节段骨折脱位患者的病历资料进行回顾性分析。其中男性8例,女性1例,年龄24-63岁。7例连续型损伤的病例均行前路减压植骨...目的探讨一期前后联合入路内固定治疗颈椎多节段骨折脱位。方法对1997至2003年9例同时伴有颈椎前后柱损伤的颈椎多节段骨折脱位患者的病历资料进行回顾性分析。其中男性8例,女性1例,年龄24-63岁。7例连续型损伤的病例均行前路减压植骨融合钢板内固定加后路椎板减压侧块螺钉钢板固定;2例Ⅱ型齿突骨折合并下颈椎骨折脱位的患者行前路齿突螺钉固定加下颈椎后方侧块螺钉固定。术前均行颅骨牵引,手术在全麻下操作。采用Frankel分级和ASIA运动指数评分评估患者的神经功能,其中Frankel A 4例,Frankel B 2例,Frankel C 2例,Frankel E 1例。ASIA运动指数评分平均为31．3分。术后平均随访2年7个月。结果随访患者获得满意的复位固定及融合,无手术并发症。无钢板螺钉松动或断裂。3例患者神经损伤有恢复,其中2例神经根功能恢复,1例脊髓功能恢复正常。ASIA运动指数评分平均为63．8分。结论一期前后路联合内固定的方法,短时间内使多节段颈椎损伤获得减压和稳定,最大限度地为神经功能的恢复创造了条件并便于早期功能锻炼,是可行的治疗颈椎多节段损伤的选择。展开更多
Degenerative cervical myelopathy is a common cause of spinal cord injury,with longer symptom duration and higher myelopathy severity indicating a worse prognosis.While numerous studies have investigated serological bi...Degenerative cervical myelopathy is a common cause of spinal cord injury,with longer symptom duration and higher myelopathy severity indicating a worse prognosis.While numerous studies have investigated serological biomarkers for acute spinal cord injury,few studies have explored such biomarkers for diagnosing degenerative cervical myelopathy.This study involved 30 patients with degenerative cervical myelopathy(51.3±7.3 years old,12 women and 18 men),seven healthy controls(25.7±1.7 years old,one woman and six men),and nine patients with cervical spondylotic radiculopathy(51.9±8.6 years old,three women and six men).Analysis of blood samples from the three groups showed clear differences in transcriptomic characteristics.Enrichment analysis identified 128 differentially expressed genes that were enriched in patients with neurological disabilities.Using least absolute shrinkage and selection operator analysis,we constructed a five-gene model(TBCD,TPM2,PNKD,EIF4G2,and AP5Z1)to diagnose degenerative cervical myelopathy with an accuracy of 93.5%.One-gene models(TCAP and SDHA)identified mild and severe degenerative cervical myelopathy with accuracies of 83.3%and 76.7%,respectively.Signatures of two immune cell types(memory B cells and memory-activated CD4^(+)T cells)predicted levels of lesions in degenerative cervical myelopathy with 80%accuracy.Our results suggest that peripheral blood RNA biomarkers could be used to predict lesion severity in degenerative cervical myelopathy.展开更多
文摘目的探讨一期前后联合入路内固定治疗颈椎多节段骨折脱位。方法对1997至2003年9例同时伴有颈椎前后柱损伤的颈椎多节段骨折脱位患者的病历资料进行回顾性分析。其中男性8例,女性1例,年龄24-63岁。7例连续型损伤的病例均行前路减压植骨融合钢板内固定加后路椎板减压侧块螺钉钢板固定;2例Ⅱ型齿突骨折合并下颈椎骨折脱位的患者行前路齿突螺钉固定加下颈椎后方侧块螺钉固定。术前均行颅骨牵引,手术在全麻下操作。采用Frankel分级和ASIA运动指数评分评估患者的神经功能,其中Frankel A 4例,Frankel B 2例,Frankel C 2例,Frankel E 1例。ASIA运动指数评分平均为31．3分。术后平均随访2年7个月。结果随访患者获得满意的复位固定及融合,无手术并发症。无钢板螺钉松动或断裂。3例患者神经损伤有恢复,其中2例神经根功能恢复,1例脊髓功能恢复正常。ASIA运动指数评分平均为63．8分。结论一期前后路联合内固定的方法,短时间内使多节段颈椎损伤获得减压和稳定,最大限度地为神经功能的恢复创造了条件并便于早期功能锻炼,是可行的治疗颈椎多节段损伤的选择。
文摘目的:探讨颈椎过伸性损伤中椎间盘韧带复合体(disco-ligamentous complex,DLC)损伤的影像特点及其临床意义。方法:对2007年7月～2011年11月在我院手术治疗且病历资料完整的50例颈椎过伸性损伤患者的临床资料进行回顾性分析。均有颈脊髓损伤,脊髓功能Frankel分级:A级4例,B级8例,C级11例,D级27例。按术前患者X线片、CT及MRI显示的脊髓受压原因,将患者分为3组:单纯单个椎间盘突出(herniated nucleus pulposus,HNP)组14例,合并颈椎病(cervical spondylosis,CS)组26例,合并后纵韧带骨化(ossification of the posterior longitudinal ligament,OPLL)组10例,分析各组患者DLC损伤的影像特点及手术方式的异同。结果:50例患者均有颈椎前纵韧带和椎间盘的损伤,其中8例伴后纵韧带损伤,5例伴关节突骨折,3例伴棘突间韧带损伤。50例患者均有颈脊髓受压与损伤,均行颈椎减压、融合与内固定术,手术节段包括DLC损伤节段与脊髓受压节段。HNP组的DLC损伤均为1个节段,DLC损伤节段与脊髓受压节段一致率为92.85%,均采用前路手术。合并CS组,1个节段DLC损伤16例,2个节段6例,3个节段4例,多节段损伤时均为相邻节段,DLC损伤节段与脊髓受压节段一致率为84.61%,行前路手术23例、后路手术3例。合并OPLL组,1个节段DLC损伤4例,2个节段6例,DLC损伤节段与脊髓受压节段一致率为60%,行前路手术1例、后路手术5例、前后联合入路手术4例。术后3个月时脊髓功能Frankel分级,28例提高1级,22例无变化。结论:颈椎过伸性损伤患者的DLC损伤特点与术前的颈椎病理状态有关,DLC损伤节段与脊髓受压节段不完全一致;制定手术方案时,颈椎稳定性重建应包括DLC损伤节段,同时兼顾脊髓受压节段的减压。
基金supported by Hunan Provincial Key Research and Development Program,No.2021SK2002(to BW)the Natural Science Foundation of Hunan Province of China(General Program),No.2021JJ30938(to YL)。
文摘Degenerative cervical myelopathy is a common cause of spinal cord injury,with longer symptom duration and higher myelopathy severity indicating a worse prognosis.While numerous studies have investigated serological biomarkers for acute spinal cord injury,few studies have explored such biomarkers for diagnosing degenerative cervical myelopathy.This study involved 30 patients with degenerative cervical myelopathy(51.3±7.3 years old,12 women and 18 men),seven healthy controls(25.7±1.7 years old,one woman and six men),and nine patients with cervical spondylotic radiculopathy(51.9±8.6 years old,three women and six men).Analysis of blood samples from the three groups showed clear differences in transcriptomic characteristics.Enrichment analysis identified 128 differentially expressed genes that were enriched in patients with neurological disabilities.Using least absolute shrinkage and selection operator analysis,we constructed a five-gene model(TBCD,TPM2,PNKD,EIF4G2,and AP5Z1)to diagnose degenerative cervical myelopathy with an accuracy of 93.5%.One-gene models(TCAP and SDHA)identified mild and severe degenerative cervical myelopathy with accuracies of 83.3%and 76.7%,respectively.Signatures of two immune cell types(memory B cells and memory-activated CD4^(+)T cells)predicted levels of lesions in degenerative cervical myelopathy with 80%accuracy.Our results suggest that peripheral blood RNA biomarkers could be used to predict lesion severity in degenerative cervical myelopathy.
