Cattle encephalon glycoside and ignotin(CEGI)injection is a compound preparation formed by a combination of muscle extract from hea lthy rabbits and brain gangliosides from cattle,and it is generally used as a neuropr...Cattle encephalon glycoside and ignotin(CEGI)injection is a compound preparation formed by a combination of muscle extract from hea lthy rabbits and brain gangliosides from cattle,and it is generally used as a neuroprotectant in the treatment of central and peripheral nerve injuries.However,there is still a need for high-level clinical evidence from large samples to support the use of CEGI.We therefore carried out a prospective,multicenter,randomized,double-blind,parallel-group,placebo-controlled study in which we recruited 319 patients with acute cerebral infarction from 16 centers in China from October 2013 to May 2016.The patients were randomized at a 3:1 ratio into CEGI(n=239;155 male,84 female;61.2±9.2 years old)and placebo(n=80;46 male,34 female;63.2±8.28 years old)groups.All patients were given standard care once daily for 14 days,including a 200 mg aspirin enteric-coated tablet and 20 mg atorvastatin calcium,both taken orally,and intravenous infusion of 250–500 mL 0.9%sodium chloride containing 40 mg sodium tanshinone IIA sulfonate.Based on conventional treatment,patients in the CEGI and placebo groups were given 12 mL CEGI or 12 mL sterile water,respectively,in an intravenous drip of 250 mL 0.9%sodium chloride(2 mL/min)once daily for 14 days.According to baseline National Institutes of Health Stroke Scale scores,patients in the two groups were divided into mild and moderate subgroups.Based on the modified Rankin Scale results,the rate of patients with good outcomes in the CEGI group was higher than that in the placebo group,and the rate of disability in the CEGI group was lower than that in the placebo group on day 90 after treatment.In the CEGI group,neurological deficits were decreased on days 14 and 90 after treatment,as measured by the National Institutes of Health Stroke Scale and the Barthel Index.Subgroup analysis revealed that CEGI led to more significant improvements in moderate stroke patients.No drug-related adverse events occurred in the CEGI or placebo groups.In conclusion,CEGI may be a 展开更多
为了解广西反刍动物鹿流行性出血热病毒(EHDV)的感染情况,本研究在广西马山县设立牛羊虫媒病监控点,筛选EHDV抗体阴性的10头牛和5只羊作为哨兵动物,分别混养在EHDV抗体阳性的牛群及羊群中,采取白天放牧,夜间赶回栏舍的方式饲养。采用竞...为了解广西反刍动物鹿流行性出血热病毒(EHDV)的感染情况,本研究在广西马山县设立牛羊虫媒病监控点,筛选EHDV抗体阴性的10头牛和5只羊作为哨兵动物,分别混养在EHDV抗体阳性的牛群及羊群中,采取白天放牧,夜间赶回栏舍的方式饲养。采用竞争性ELISA全年监测其抗体转阳情况,取抗体阳转动物的红细胞,接种BHK-21细胞分离EHDV。以RT-PCR、病毒中和试验等对分离株进行鉴定,结果在3头哨兵牛EHDV抗体转阳前后的7份抗凝血中分离到3株病毒,TCID50分别为102.5/0.1 m L、102.83/0.1 m L和102.5/0.1 m L,血清型均为EHDV-5型。该结果为首次在广西牛群中分离到EHDV,表明广西反刍动物存在EHDV感染。本研究为国家监测反刍动物重要虫媒病毒病流行情况和疫病风险分析提供了有价值的参考资料。展开更多
文摘Cattle encephalon glycoside and ignotin(CEGI)injection is a compound preparation formed by a combination of muscle extract from hea lthy rabbits and brain gangliosides from cattle,and it is generally used as a neuroprotectant in the treatment of central and peripheral nerve injuries.However,there is still a need for high-level clinical evidence from large samples to support the use of CEGI.We therefore carried out a prospective,multicenter,randomized,double-blind,parallel-group,placebo-controlled study in which we recruited 319 patients with acute cerebral infarction from 16 centers in China from October 2013 to May 2016.The patients were randomized at a 3:1 ratio into CEGI(n=239;155 male,84 female;61.2±9.2 years old)and placebo(n=80;46 male,34 female;63.2±8.28 years old)groups.All patients were given standard care once daily for 14 days,including a 200 mg aspirin enteric-coated tablet and 20 mg atorvastatin calcium,both taken orally,and intravenous infusion of 250–500 mL 0.9%sodium chloride containing 40 mg sodium tanshinone IIA sulfonate.Based on conventional treatment,patients in the CEGI and placebo groups were given 12 mL CEGI or 12 mL sterile water,respectively,in an intravenous drip of 250 mL 0.9%sodium chloride(2 mL/min)once daily for 14 days.According to baseline National Institutes of Health Stroke Scale scores,patients in the two groups were divided into mild and moderate subgroups.Based on the modified Rankin Scale results,the rate of patients with good outcomes in the CEGI group was higher than that in the placebo group,and the rate of disability in the CEGI group was lower than that in the placebo group on day 90 after treatment.In the CEGI group,neurological deficits were decreased on days 14 and 90 after treatment,as measured by the National Institutes of Health Stroke Scale and the Barthel Index.Subgroup analysis revealed that CEGI led to more significant improvements in moderate stroke patients.No drug-related adverse events occurred in the CEGI or placebo groups.In conclusion,CEGI may be a
文摘为了解广西反刍动物鹿流行性出血热病毒(EHDV)的感染情况,本研究在广西马山县设立牛羊虫媒病监控点,筛选EHDV抗体阴性的10头牛和5只羊作为哨兵动物,分别混养在EHDV抗体阳性的牛群及羊群中,采取白天放牧,夜间赶回栏舍的方式饲养。采用竞争性ELISA全年监测其抗体转阳情况,取抗体阳转动物的红细胞,接种BHK-21细胞分离EHDV。以RT-PCR、病毒中和试验等对分离株进行鉴定,结果在3头哨兵牛EHDV抗体转阳前后的7份抗凝血中分离到3株病毒,TCID50分别为102.5/0.1 m L、102.83/0.1 m L和102.5/0.1 m L,血清型均为EHDV-5型。该结果为首次在广西牛群中分离到EHDV,表明广西反刍动物存在EHDV感染。本研究为国家监测反刍动物重要虫媒病毒病流行情况和疫病风险分析提供了有价值的参考资料。
