Background: Chronic spontaneous urticaria (CSU) is a complex medical condition characterized by substantial morbidity and a negative impact on one’s quality of life. There are several treatment approaches available, ...Background: Chronic spontaneous urticaria (CSU) is a complex medical condition characterized by substantial morbidity and a negative impact on one’s quality of life. There are several treatment approaches available, tailored to the severity of the condition, which can enhance overall quality of life. Aim: In this article, we outline a systematic approach to managing chronic urticaria, while also elucidating the available treatment strategies for cases that prove resistant to conventional therapies. To illustrate our points, we present a clinical case as a practical example. Case Presentation: Here, we present a patient with CSU since childhood who presented in the context of refractory hives and generalized arthralgia that responded well to omalizumab therapy with no further relapse. Conclusion: Omalizumab is a biological agent that offers a potential treatment option for CSU. It is available for individuals twelve years and older who have not responded well to conventional treatments. It has demonstrated good efficacy with a relatively low rate of clinically significant adverse effects. Nonetheless, there is a dearth of research regarding the optimal method for tapering the dosage and determining the duration of treatment.展开更多
The analysis of residue-residue contacts in protein structures can shed some light on our understanding of the folding and stability of proteins. In this paper, we study the statistical properties of long-range and sh...The analysis of residue-residue contacts in protein structures can shed some light on our understanding of the folding and stability of proteins. In this paper, we study the statistical properties of long-range and short-range residue- residue contacts of 91 globular proteins using CSU software and analyze the importance of long-range contacts in globular protein structure. There are many short-range and long-range contacts in globular proteins, and it is found that the average number of long-range contacts per residue is 5.63 and the percentage of residue-residue contacts which are involved in long- range ones is 59.4%. In more detail, the distribution of long-range contacts in different residue intervals is investigated and it is found that the residues occurring in the interval range of 4-10 residues apart in the sequence contribute more long-range contacts to the stability of globular protein. The number of long-range contacts per residue, which is a measure of ability to form residue-residue contacts, is also calculated for 20 different amino acid residues. It is shown that hydrophobic residues (including Leu, Val, He, Met, Phe, Tyr, Cys and Trp) having a large number of long-range contacts easily form long-range contacts, while the hydrophilic amino acids (including Ala, Gly, Thr, His, Glu, Gln, Asp, Asn, Lys, Ser, Arg, and Pro) form long-range contacts with more difficulty. The relationship between the Fauchere-Pliska hydrophobicity scale (FPH) and the number of short-range and long-range contacts per residue for 20 amino acid residues is also studied. An approximately linear relationship between the Fauchere-Pliska hydrophobicity scale (FPH) and the number of long-range contacts per residue CL, is found and can be expressed as CL = a + b × FPH where a = 5.04 and b = 1.23. These results can help us to understand the role of residue-residue contacts in globular protein structure.展开更多
A 2m^3 isothermal cloud chamber mainly for ice nucleation research is described in this paper.Its structure, attached instruments and experimental procedures are also presented.The experiments of determining the ice n...A 2m^3 isothermal cloud chamber mainly for ice nucleation research is described in this paper.Its structure, attached instruments and experimental procedures are also presented.The experiments of determining the ice nuclei effectiveness for the Agl-containing aerosols produced by three formulations have been conducted and the results have been compared with those of the CSU 960-liter isothermal cloud chamber.All experimental results show that the chamber has advantages of stable performance and reproducibility.It would be expected to become a useful experimental facility for ice nucleation research.展开更多
Germany’s political parties reshuffle in the run-up to the 2009 federal election More than six months after the parliamentary election in Hesse State, Germany, on January 27, the five elected parties —
λ2 X3:致命手枪X3 Vs NiP-CPL 2001遥远的1．3时代,那些耳熟能详的名字,那些多动狂和抽搐者,那群北美瞄准疯子和欧洲战术大师……那是一个充满激情的时代,对于那场战役,我们的溢美之词已经无以复加,直到4年后的今天,我们在阅读比赛的时...λ2 X3:致命手枪X3 Vs NiP-CPL 2001遥远的1．3时代,那些耳熟能详的名字,那些多动狂和抽搐者,那群北美瞄准疯子和欧洲战术大师……那是一个充满激情的时代,对于那场战役,我们的溢美之词已经无以复加,直到4年后的今天,我们在阅读比赛的时候,仍然会有肾上腺素被激发的快感。这是双方较量的第二场,X3在北美战队最擅长的train上丢掉了首盘比赛,而这场则是在欧洲战队最擅长的nuke上展开角逐,根据比赛规则,X3如果失利,那么NiP将直接夺冠……展开更多
文摘Background: Chronic spontaneous urticaria (CSU) is a complex medical condition characterized by substantial morbidity and a negative impact on one’s quality of life. There are several treatment approaches available, tailored to the severity of the condition, which can enhance overall quality of life. Aim: In this article, we outline a systematic approach to managing chronic urticaria, while also elucidating the available treatment strategies for cases that prove resistant to conventional therapies. To illustrate our points, we present a clinical case as a practical example. Case Presentation: Here, we present a patient with CSU since childhood who presented in the context of refractory hives and generalized arthralgia that responded well to omalizumab therapy with no further relapse. Conclusion: Omalizumab is a biological agent that offers a potential treatment option for CSU. It is available for individuals twelve years and older who have not responded well to conventional treatments. It has demonstrated good efficacy with a relatively low rate of clinically significant adverse effects. Nonetheless, there is a dearth of research regarding the optimal method for tapering the dosage and determining the duration of treatment.
基金This work was supported by the National Natural Science Foundation of China (Nos. 29874012, 20174036, and20274040), and the Natural Science Foundation of Zhejiang Province (10102) and Science Technology Development Plan of Wenzhou City (S2002A014).
文摘The analysis of residue-residue contacts in protein structures can shed some light on our understanding of the folding and stability of proteins. In this paper, we study the statistical properties of long-range and short-range residue- residue contacts of 91 globular proteins using CSU software and analyze the importance of long-range contacts in globular protein structure. There are many short-range and long-range contacts in globular proteins, and it is found that the average number of long-range contacts per residue is 5.63 and the percentage of residue-residue contacts which are involved in long- range ones is 59.4%. In more detail, the distribution of long-range contacts in different residue intervals is investigated and it is found that the residues occurring in the interval range of 4-10 residues apart in the sequence contribute more long-range contacts to the stability of globular protein. The number of long-range contacts per residue, which is a measure of ability to form residue-residue contacts, is also calculated for 20 different amino acid residues. It is shown that hydrophobic residues (including Leu, Val, He, Met, Phe, Tyr, Cys and Trp) having a large number of long-range contacts easily form long-range contacts, while the hydrophilic amino acids (including Ala, Gly, Thr, His, Glu, Gln, Asp, Asn, Lys, Ser, Arg, and Pro) form long-range contacts with more difficulty. The relationship between the Fauchere-Pliska hydrophobicity scale (FPH) and the number of short-range and long-range contacts per residue for 20 amino acid residues is also studied. An approximately linear relationship between the Fauchere-Pliska hydrophobicity scale (FPH) and the number of long-range contacts per residue CL, is found and can be expressed as CL = a + b × FPH where a = 5.04 and b = 1.23. These results can help us to understand the role of residue-residue contacts in globular protein structure.
文摘A 2m^3 isothermal cloud chamber mainly for ice nucleation research is described in this paper.Its structure, attached instruments and experimental procedures are also presented.The experiments of determining the ice nuclei effectiveness for the Agl-containing aerosols produced by three formulations have been conducted and the results have been compared with those of the CSU 960-liter isothermal cloud chamber.All experimental results show that the chamber has advantages of stable performance and reproducibility.It would be expected to become a useful experimental facility for ice nucleation research.
文摘Germany’s political parties reshuffle in the run-up to the 2009 federal election More than six months after the parliamentary election in Hesse State, Germany, on January 27, the five elected parties —
文摘λ2 X3:致命手枪X3 Vs NiP-CPL 2001遥远的1．3时代,那些耳熟能详的名字,那些多动狂和抽搐者,那群北美瞄准疯子和欧洲战术大师……那是一个充满激情的时代,对于那场战役,我们的溢美之词已经无以复加,直到4年后的今天,我们在阅读比赛的时候,仍然会有肾上腺素被激发的快感。这是双方较量的第二场,X3在北美战队最擅长的train上丢掉了首盘比赛,而这场则是在欧洲战队最擅长的nuke上展开角逐,根据比赛规则,X3如果失利,那么NiP将直接夺冠……
