Gastrodin, the major component isolated from the rhizome of the Chinese traditional medicinal herb Gastrodia elata（‘‘Tianma＇＇）, has a long history in the treatment of epilepsy and other neurological disorders.Ho...Gastrodin, the major component isolated from the rhizome of the Chinese traditional medicinal herb Gastrodia elata（‘‘Tianma＇＇）, has a long history in the treatment of epilepsy and other neurological disorders.However, the molecular mechanisms are not clear. Here,we found that gastrodin ameliorated pentylenetetrazole（PTZ）-induced epileptic seizures with improvement of the electroencephalographic pattern in mice. Further studies demonstrated that gastrodin decreased the levels of the pro-inflammatory cytokines interleukin-1b and tumor necrosis factor-a while increasing interleukin-10, an antiinflammatory cytokine in the brain. Furthermore, gastrodin attenuated the PTZ-induced microglial activation along with inhibition of mitogen-activated protein kinases,c AMP response element binding protein, and NF-j B. Our data suggest that gastrodin attenuates seizures by modulating the mitogen-activated protein kinase-associated inflammatory responses.展开更多
cAMP反应元件结合蛋白(cAMP response element binding protein,CREB)是一种真核生物细胞核内调控因子,在神经元再生、突触形成及学习记忆等方面具有重要的调节作用。CREB的磷酸化是实现调节转录的重要途径,胞外信号途径影响CREB的磷酸...cAMP反应元件结合蛋白(cAMP response element binding protein,CREB)是一种真核生物细胞核内调控因子,在神经元再生、突触形成及学习记忆等方面具有重要的调节作用。CREB的磷酸化是实现调节转录的重要途径,胞外信号途径影响CREB的磷酸化来激活多种靶基因转录,表现出多种生理功能。综述了CREB的结构、调控机制,特别是磷酸化的信号通路。展开更多
文摘Gastrodin, the major component isolated from the rhizome of the Chinese traditional medicinal herb Gastrodia elata（‘‘Tianma＇＇）, has a long history in the treatment of epilepsy and other neurological disorders.However, the molecular mechanisms are not clear. Here,we found that gastrodin ameliorated pentylenetetrazole（PTZ）-induced epileptic seizures with improvement of the electroencephalographic pattern in mice. Further studies demonstrated that gastrodin decreased the levels of the pro-inflammatory cytokines interleukin-1b and tumor necrosis factor-a while increasing interleukin-10, an antiinflammatory cytokine in the brain. Furthermore, gastrodin attenuated the PTZ-induced microglial activation along with inhibition of mitogen-activated protein kinases,c AMP response element binding protein, and NF-j B. Our data suggest that gastrodin attenuates seizures by modulating the mitogen-activated protein kinase-associated inflammatory responses.
文摘cAMP反应元件结合蛋白(cAMP response element binding protein,CREB)是一种真核生物细胞核内调控因子,在神经元再生、突触形成及学习记忆等方面具有重要的调节作用。CREB的磷酸化是实现调节转录的重要途径,胞外信号途径影响CREB的磷酸化来激活多种靶基因转录,表现出多种生理功能。综述了CREB的结构、调控机制,特别是磷酸化的信号通路。
