Eight new C_(19)-diterpenoid alkaloid arabinosides, named aconicarmichosides E–L(1–8), were isolated from an aqueous extract of the lateral roots of Aconitum carmichaelii(Fu Zi). Their structures were determined by ...Eight new C_(19)-diterpenoid alkaloid arabinosides, named aconicarmichosides E–L(1–8), were isolated from an aqueous extract of the lateral roots of Aconitum carmichaelii(Fu Zi). Their structures were determined by spectroscopic and chemical methods including 2D NMR experiments and acid hydrolysis. Compounds 1–8, together with the previously reported four neoline 14-O-arabinosides from the same plant, represent the only examples of glycosidic diterpenoid alkaloids so far. At a dose of 1.0 mg/kg(i.p.), as compared with the black control, compounds 1, 2, and 4–6 exhibited analgesic effects with 465.6% inhibitions against acetic acid-induced writhing of mice. Structure–activity relationship was also discussed.展开更多
A new franchetine-type C19-diterpenoid alkaloid 3-hydroxyfranchetine 1 and a new aconitine-type C19-diterpenoid alkaloid atropurpursine 2 have been isolated from the roots of Aconitum hemsleyanium var. atropurpureum. ...A new franchetine-type C19-diterpenoid alkaloid 3-hydroxyfranchetine 1 and a new aconitine-type C19-diterpenoid alkaloid atropurpursine 2 have been isolated from the roots of Aconitum hemsleyanium var. atropurpureum. The structures of these new alkaloids were established on the basis of spectral data.展开更多
Two new C ig-diterpenoid alkaloids, 7,8-epoxy-franchetine （1） and N（19）-en-austroconitine A （2）, were isolated from Aconitum iochanicum. Compound 1 was a new C19-diterpenoid alkaloid with a 7,8-epoxy unit. Their...Two new C ig-diterpenoid alkaloids, 7,8-epoxy-franchetine （1） and N（19）-en-austroconitine A （2）, were isolated from Aconitum iochanicum. Compound 1 was a new C19-diterpenoid alkaloid with a 7,8-epoxy unit. Their structures were elucidated by comprehensive spectroscopic analyses including UV, IR, MS, 1D and 2D NMR. Biological ac- tivity tests indicated that two new compounds exhibited inhibitory activity against nitric oxide （NO） production in LPS-activated RAW264.7 macrophages. Compared with positive control, the two new compounds showed weak an- ti-inflammatory effects with the inhibition rate of 27.3% and 29.2%, respectively.展开更多
Two new C19-diterpenoid alkaloids, davidisines A （1） and B （2） along with thirteen known alkaloids were isolated from the whole herb of Delphinium davidii Franch. Their structures were established by spectral meth...Two new C19-diterpenoid alkaloids, davidisines A （1） and B （2） along with thirteen known alkaloids were isolated from the whole herb of Delphinium davidii Franch. Their structures were established by spectral methods, especially 2D NMR techniques.展开更多
Two novel C-nor-B-homo aconane-type diterpenes 4 and 5, featuring a unique eight-membered ring system, were obtained by the treatment of C-nor-C19-diterpenoid alkaloid 3 with HNO2 in 8% and 21% yields, respectively. S...Two novel C-nor-B-homo aconane-type diterpenes 4 and 5, featuring a unique eight-membered ring system, were obtained by the treatment of C-nor-C19-diterpenoid alkaloid 3 with HNO2 in 8% and 21% yields, respectively. Structures of these two compounds were established based on the combination of spectroscopic data, including HRESIMS, 1D and 2D NMR data. A olausible mechanism for the formation of 4 and 5 is also presented.展开更多
Three new lycoctonine-type C19-diterpenoid alkaloids, laxicymine 1, laxicymisine 2, and laxicyminine 3 have been isolated from the whole herb of Delphinium laxicymosum var. pilostachyum W.T. Wang. Their structures wer...Three new lycoctonine-type C19-diterpenoid alkaloids, laxicymine 1, laxicymisine 2, and laxicyminine 3 have been isolated from the whole herb of Delphinium laxicymosum var. pilostachyum W.T. Wang. Their structures were established by spectra data.展开更多
A new synthesis of the bridged [6-6-6] ABE tricyclic ring analogues of methyllycaconitine with the C-1 oxygenated substituents has been developed using an efficient aza-annulation of β-enamino ketone followed by a fa...A new synthesis of the bridged [6-6-6] ABE tricyclic ring analogues of methyllycaconitine with the C-1 oxygenated substituents has been developed using an efficient aza-annulation of β-enamino ketone followed by a facile decarboxylation to form BE rings.Subsequent elaboration to form the A ring was achieved by a transannular acyl radical cyclization with concomitant equipment of the key C-1 oxygen functionality.展开更多
目的研究天台山翠雀花Delphinium taiantishanense W.J.Zhang et G.H.Chen中生物碱的化学成分。方法采用酸提碱沉法提取总碱,硅胶层析法分离,波谱法鉴定结构。结果从中分得7个单体化合物。结论应用光谱法鉴定了这些化合物的结构。7个化...目的研究天台山翠雀花Delphinium taiantishanense W.J.Zhang et G.H.Chen中生物碱的化学成分。方法采用酸提碱沉法提取总碱,硅胶层析法分离,波谱法鉴定结构。结果从中分得7个单体化合物。结论应用光谱法鉴定了这些化合物的结构。7个化合物均为已知的C19-二萜生物碱,分别为:6-acetyldelpheline、deltaline、氨茴酰牛扁碱、牛扁碱、德尔色明甲、德尔色明乙和甲基牛扁碱。展开更多
基金Financial support from the National Natural Sciences Foundation of China(81630094,21732008,81373388,and 81573445)CAMS Innovation Fund for Medical Science(2017-I2M-3–010,2016-I2M-1–004,2016-I2M-1–010,and 2017-I2M-3–011)
文摘Eight new C_(19)-diterpenoid alkaloid arabinosides, named aconicarmichosides E–L(1–8), were isolated from an aqueous extract of the lateral roots of Aconitum carmichaelii(Fu Zi). Their structures were determined by spectroscopic and chemical methods including 2D NMR experiments and acid hydrolysis. Compounds 1–8, together with the previously reported four neoline 14-O-arabinosides from the same plant, represent the only examples of glycosidic diterpenoid alkaloids so far. At a dose of 1.0 mg/kg(i.p.), as compared with the black control, compounds 1, 2, and 4–6 exhibited analgesic effects with 465.6% inhibitions against acetic acid-induced writhing of mice. Structure–activity relationship was also discussed.
文摘A new franchetine-type C19-diterpenoid alkaloid 3-hydroxyfranchetine 1 and a new aconitine-type C19-diterpenoid alkaloid atropurpursine 2 have been isolated from the roots of Aconitum hemsleyanium var. atropurpureum. The structures of these new alkaloids were established on the basis of spectral data.
文摘Two new C ig-diterpenoid alkaloids, 7,8-epoxy-franchetine （1） and N（19）-en-austroconitine A （2）, were isolated from Aconitum iochanicum. Compound 1 was a new C19-diterpenoid alkaloid with a 7,8-epoxy unit. Their structures were elucidated by comprehensive spectroscopic analyses including UV, IR, MS, 1D and 2D NMR. Biological ac- tivity tests indicated that two new compounds exhibited inhibitory activity against nitric oxide （NO） production in LPS-activated RAW264.7 macrophages. Compared with positive control, the two new compounds showed weak an- ti-inflammatory effects with the inhibition rate of 27.3% and 29.2%, respectively.
文摘Two new C19-diterpenoid alkaloids, davidisines A （1） and B （2） along with thirteen known alkaloids were isolated from the whole herb of Delphinium davidii Franch. Their structures were established by spectral methods, especially 2D NMR techniques.
基金support for this research was provided from the National Natural Science Foundation of China(No.30472075)the Excellent Ph.D.Dissertation Foundation of China(No.200367).
文摘Two novel C-nor-B-homo aconane-type diterpenes 4 and 5, featuring a unique eight-membered ring system, were obtained by the treatment of C-nor-C19-diterpenoid alkaloid 3 with HNO2 in 8% and 21% yields, respectively. Structures of these two compounds were established based on the combination of spectroscopic data, including HRESIMS, 1D and 2D NMR data. A olausible mechanism for the formation of 4 and 5 is also presented.
文摘Three new lycoctonine-type C19-diterpenoid alkaloids, laxicymine 1, laxicymisine 2, and laxicyminine 3 have been isolated from the whole herb of Delphinium laxicymosum var. pilostachyum W.T. Wang. Their structures were established by spectra data.
基金National Natural Science Foundation of China (Nos.21472129 and 21871190) for financial support of this work by grants。
文摘A new synthesis of the bridged [6-6-6] ABE tricyclic ring analogues of methyllycaconitine with the C-1 oxygenated substituents has been developed using an efficient aza-annulation of β-enamino ketone followed by a facile decarboxylation to form BE rings.Subsequent elaboration to form the A ring was achieved by a transannular acyl radical cyclization with concomitant equipment of the key C-1 oxygen functionality.
文摘目的研究天台山翠雀花Delphinium taiantishanense W.J.Zhang et G.H.Chen中生物碱的化学成分。方法采用酸提碱沉法提取总碱,硅胶层析法分离,波谱法鉴定结构。结果从中分得7个单体化合物。结论应用光谱法鉴定了这些化合物的结构。7个化合物均为已知的C19-二萜生物碱,分别为:6-acetyldelpheline、deltaline、氨茴酰牛扁碱、牛扁碱、德尔色明甲、德尔色明乙和甲基牛扁碱。
基金the National Natural Science Foundation of China(31860095)Guizhou Science and Technology Foundation of China(QKHJC[2018]1193)Zhuhai Premier-Discipline Enhancement Scheme of Pharmacology,Zhuhai Campus of Zunyi Medical University
