Burn wounds result in varying degrees of soft tissue damage that are typically graded clinically.Recently a key participant in neovascularization,the endothelial progenitor cel,has been the subject of intense cardiova...Burn wounds result in varying degrees of soft tissue damage that are typically graded clinically.Recently a key participant in neovascularization,the endothelial progenitor cel,has been the subject of intense cardiovascular research to explore whether it can serve as a biomarker for vascular injury.In this review,we examine the identity of the endothelial progenitor cell as well as the evidence that support its role as a key responder after burn insult.While there is conflicting evidence with regards to the delta of endothelial progenitor cell mobilization and burn severity,it is clear that they play an important role in wound healing.Systematic and controlled studies are needed to clarify this relationship,and whether this population can serve as a biomarker for burn severity.展开更多
Scald injuries,which describe burns to living tissue from hot liquids,are a very common injury that occur across geographical,social,economic,and national boundaries.Despite their ubiquitous nature,a complete understa...Scald injuries,which describe burns to living tissue from hot liquids,are a very common injury that occur across geographical,social,economic,and national boundaries.Despite their ubiquitous nature,a complete understanding of the conditions which are required to cause scald burns is not yet available.In addition,clear guidance to medical practitioners is available through various guidelines however in actual situations,the extent of the burn is not fully known and this lack of knowledge complicates care.Here,a comprehensive review is made of the available knowledge of temperatures and scald durations which lead to skin-burn injuries.The range of volumes and liquid temperatures are typical of those found in heated consumer beverages.This review can help medical practitioners design initial treatment protocols and can be used by manufacturers of hot-liquid products to avoid the most severe burns.Next,within the context of this ability to quantify burn depths,a review of current burn treatment guidelines is given.Included in this review is a visual recognition of the extent of burns into the dermal layer as well as decision guidelines for selection of patients which would benefit from referral to a dedicated burn center.It is hoped that by bringing together both the quantified burn-depth information and current treatment guidelines,this review can be used as a resource for persons in the medical,manufacturing,beverage service,and other industries to reduce the human impact of scald injuries.展开更多
基金This work was supported in part by the California Institute for Regenerative Medicine training grant award TG2-012252 from the University of California,Irvine
文摘Burn wounds result in varying degrees of soft tissue damage that are typically graded clinically.Recently a key participant in neovascularization,the endothelial progenitor cel,has been the subject of intense cardiovascular research to explore whether it can serve as a biomarker for vascular injury.In this review,we examine the identity of the endothelial progenitor cell as well as the evidence that support its role as a key responder after burn insult.While there is conflicting evidence with regards to the delta of endothelial progenitor cell mobilization and burn severity,it is clear that they play an important role in wound healing.Systematic and controlled studies are needed to clarify this relationship,and whether this population can serve as a biomarker for burn severity.
文摘Scald injuries,which describe burns to living tissue from hot liquids,are a very common injury that occur across geographical,social,economic,and national boundaries.Despite their ubiquitous nature,a complete understanding of the conditions which are required to cause scald burns is not yet available.In addition,clear guidance to medical practitioners is available through various guidelines however in actual situations,the extent of the burn is not fully known and this lack of knowledge complicates care.Here,a comprehensive review is made of the available knowledge of temperatures and scald durations which lead to skin-burn injuries.The range of volumes and liquid temperatures are typical of those found in heated consumer beverages.This review can help medical practitioners design initial treatment protocols and can be used by manufacturers of hot-liquid products to avoid the most severe burns.Next,within the context of this ability to quantify burn depths,a review of current burn treatment guidelines is given.Included in this review is a visual recognition of the extent of burns into the dermal layer as well as decision guidelines for selection of patients which would benefit from referral to a dedicated burn center.It is hoped that by bringing together both the quantified burn-depth information and current treatment guidelines,this review can be used as a resource for persons in the medical,manufacturing,beverage service,and other industries to reduce the human impact of scald injuries.
