Objective： To perform meta-analyses evaluating the efficacy of adding Liuwei Dihuang Pills （六味地黄丸 LDP） to Western medicine in improving treatment outcomes for type 2 diabetes. Methods： Medline, PubMed, Cochra...Objective： To perform meta-analyses evaluating the efficacy of adding Liuwei Dihuang Pills （六味地黄丸 LDP） to Western medicine in improving treatment outcomes for type 2 diabetes. Methods： Medline, PubMed, Cochrane Library, and Chinese databases, including the Chinese National Knowledge Infrastructure were searched to identify eligible studies; i.e., if the study involved a randomized clinical trial in which the experimental group combined LDP with Western drugs and the control group used the corresponding Western drugs alone to treat type 2 diabetes. Outcomes were measured in terms of fasting blood glucose （FBG）, postprandial blood glucose （2hPG） and HbAlc level. Efficacy was also measured by using control and response rates. The combined odds ratio （OR）, mean difference （MD）, and 95% confidence intervals （95% CI） were calculated. Results： Studies included in the analysis were less adequate than expected in terms of methodological qualify. A total of 1,609 patients from 18 studies were included. We found that adding LDP can lower patients＇ FBG （MD=0.54 mmol/L, 95% CI [0.15, 0.93], P=0.007）, 2hPG （MD=1.05 mmol/L, 95% CI [0.29, 1.81], P〈0.01） and HbAlc （MD=0.23, 95% CI [0.02, 0.45], P=0.008）. There were also improvements in treatment response rates （OR=3.41, 95% CI [2.38, 4.90], P〈0.01） and control rates （OR=2.47, 95% CI [1.91, 3.20], P〈0.01）. Conclusion： Adding LDP to Western medicine might improve treatment outcomes of diabetes, including FBG, 2hPG, response rates and control rates.展开更多
目的:探讨甘精胰岛素在肝源性糖尿病中的应用价值.方法:应用甘精胰岛素控制82例肝源性糖尿病患者的血糖,随后对其空腹血糖(fasting b l o o d g l u c o s e,F B G)、餐后2 h血糖(2 h postprandial blood glucose,2 h PBG)及低血糖发生...目的:探讨甘精胰岛素在肝源性糖尿病中的应用价值.方法:应用甘精胰岛素控制82例肝源性糖尿病患者的血糖,随后对其空腹血糖(fasting b l o o d g l u c o s e,F B G)、餐后2 h血糖(2 h postprandial blood glucose,2 h PBG)及低血糖发生等情况进行随访24 wk,每12 wk检测一次糖化血红蛋白(glycosylated hemoglobin,HbAlc),然后将治疗12、24 wk后的FBG、2 h PBG及HbAlc与治疗前比较.结果:治疗12 wk后FBG、2 h PBG及HbAlc均较治疗前明显下降(FBG:6.35 mmol/L±1.47 mmol/L vs 10.52 mmol/L±3.13 mmol/L,P<0.05;2 h PBG:9.81 mmol/L±3.14 mmol/L vs17.51 mmol/L±4.33 mmol/L,P<0.05;HbAlc:7.54%±1.31%vs 10.65%±1.43%,P<0.05),而治疗24 wk后血糖及HbAlc与治疗12 wk后相比无明显变化(FBG:6.47 mmol/L±1.25 mmol/L vs 6.35 mmol/L±1.47 mmol/L,P>0.05;2h PBG:8.91 mmol/L±2.76 mmol/L vs 9.81mmol/L±3.14 mmol/L,P>0.05;HbAlc:7.28%±1.12%vs 7.54%±1.31%,P>0.05),治疗期间低血糖发生率低,仅仅发生过一次.结论:甘精胰岛素对肝源性糖尿病的血糖控制安全有效.展开更多
基金Supported by the National Key Technology Research and Development Program of the People's Republic of China(No.2009BAI76B030900)
文摘Objective： To perform meta-analyses evaluating the efficacy of adding Liuwei Dihuang Pills （六味地黄丸 LDP） to Western medicine in improving treatment outcomes for type 2 diabetes. Methods： Medline, PubMed, Cochrane Library, and Chinese databases, including the Chinese National Knowledge Infrastructure were searched to identify eligible studies; i.e., if the study involved a randomized clinical trial in which the experimental group combined LDP with Western drugs and the control group used the corresponding Western drugs alone to treat type 2 diabetes. Outcomes were measured in terms of fasting blood glucose （FBG）, postprandial blood glucose （2hPG） and HbAlc level. Efficacy was also measured by using control and response rates. The combined odds ratio （OR）, mean difference （MD）, and 95% confidence intervals （95% CI） were calculated. Results： Studies included in the analysis were less adequate than expected in terms of methodological qualify. A total of 1,609 patients from 18 studies were included. We found that adding LDP can lower patients＇ FBG （MD=0.54 mmol/L, 95% CI [0.15, 0.93], P=0.007）, 2hPG （MD=1.05 mmol/L, 95% CI [0.29, 1.81], P〈0.01） and HbAlc （MD=0.23, 95% CI [0.02, 0.45], P=0.008）. There were also improvements in treatment response rates （OR=3.41, 95% CI [2.38, 4.90], P〈0.01） and control rates （OR=2.47, 95% CI [1.91, 3.20], P〈0.01）. Conclusion： Adding LDP to Western medicine might improve treatment outcomes of diabetes, including FBG, 2hPG, response rates and control rates.
文摘目的:探讨甘精胰岛素在肝源性糖尿病中的应用价值.方法:应用甘精胰岛素控制82例肝源性糖尿病患者的血糖,随后对其空腹血糖(fasting b l o o d g l u c o s e,F B G)、餐后2 h血糖(2 h postprandial blood glucose,2 h PBG)及低血糖发生等情况进行随访24 wk,每12 wk检测一次糖化血红蛋白(glycosylated hemoglobin,HbAlc),然后将治疗12、24 wk后的FBG、2 h PBG及HbAlc与治疗前比较.结果:治疗12 wk后FBG、2 h PBG及HbAlc均较治疗前明显下降(FBG:6.35 mmol/L±1.47 mmol/L vs 10.52 mmol/L±3.13 mmol/L,P<0.05;2 h PBG:9.81 mmol/L±3.14 mmol/L vs17.51 mmol/L±4.33 mmol/L,P<0.05;HbAlc:7.54%±1.31%vs 10.65%±1.43%,P<0.05),而治疗24 wk后血糖及HbAlc与治疗12 wk后相比无明显变化(FBG:6.47 mmol/L±1.25 mmol/L vs 6.35 mmol/L±1.47 mmol/L,P>0.05;2h PBG:8.91 mmol/L±2.76 mmol/L vs 9.81mmol/L±3.14 mmol/L,P>0.05;HbAlc:7.28%±1.12%vs 7.54%±1.31%,P>0.05),治疗期间低血糖发生率低,仅仅发生过一次.结论:甘精胰岛素对肝源性糖尿病的血糖控制安全有效.
