目的分析整体护理对糖尿病视网膜病变患者血糖水平、视力恢复的影响。方法选取2020年1月至2021年12月收治的150例糖尿病视网膜病变患者为研究对象,随机将其分为常规组和观察组,每组75例。常规组给予常规护理,观察组给予整体护理。比较...目的分析整体护理对糖尿病视网膜病变患者血糖水平、视力恢复的影响。方法选取2020年1月至2021年12月收治的150例糖尿病视网膜病变患者为研究对象,随机将其分为常规组和观察组,每组75例。常规组给予常规护理,观察组给予整体护理。比较两组的护理效果。结果观察组的视力恢复总有效率显著高于常规组(P<0.05)。护理后,观察组的收缩期峰值流速(PSV)、舒张末期血流速度(EDV)、平均流速(Vm)均显著高于常规组,阻力指数(RI)、搏动指数(PI)均显著低于常规组(P<0.05)。护理后,观察组的空腹血糖(FPG)、餐后2 h血糖(2 h PG)水平、糖化血红蛋白(HbA1c)均显著低于常规组,中文版低视力者生活质量量表(CLVQOL-25)评分显著高于常规组(P<0.05)。观察组的护理满意度显著高于常规组(P<0.05)。结论整体护理在糖尿病视网膜病变中的应用效果显著,值得临床推广和应用。展开更多
Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the ...Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGCs). However, the use of tNGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGCs and compared the various features of these improved silk^(+) tNGCs with the tubes without holes(silk^(–) tNGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimization of the macroscopic holes silk^(+) tNGC a展开更多
文摘目的分析整体护理对糖尿病视网膜病变患者血糖水平、视力恢复的影响。方法选取2020年1月至2021年12月收治的150例糖尿病视网膜病变患者为研究对象,随机将其分为常规组和观察组,每组75例。常规组给予常规护理,观察组给予整体护理。比较两组的护理效果。结果观察组的视力恢复总有效率显著高于常规组(P<0.05)。护理后,观察组的收缩期峰值流速(PSV)、舒张末期血流速度(EDV)、平均流速(Vm)均显著高于常规组,阻力指数(RI)、搏动指数(PI)均显著低于常规组(P<0.05)。护理后,观察组的空腹血糖(FPG)、餐后2 h血糖(2 h PG)水平、糖化血红蛋白(HbA1c)均显著低于常规组,中文版低视力者生活质量量表(CLVQOL-25)评分显著高于常规组(P<0.05)。观察组的护理满意度显著高于常规组(P<0.05)。结论整体护理在糖尿病视网膜病变中的应用效果显著,值得临床推广和应用。
基金supported by the Lorenz B?hler Fonds,#2/19 (obtained by the Neuroregeneration Group,Ludwig Boltzmann Institute for Traumatology)the City of Vienna project ImmunTissue,MA23#30-11 (obtained by the Department Life Science Engineering,University of Applied Sciences Technikum Wien)。
文摘Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGCs). However, the use of tNGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGCs and compared the various features of these improved silk^(+) tNGCs with the tubes without holes(silk^(–) tNGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimization of the macroscopic holes silk^(+) tNGC a
