目的探讨曲靖地区初诊2型糖尿病(T2DM)患者糖化血红蛋白(HbA1c)与血脂谱、空腹血糖(FBG)及餐后2 h血糖(2 h PG)水平的关系。方法选择2019年3—12月作者在曲靖市第一人民医院国家住院医师规范化培训期间收治的100例初诊T2DM患者作为研究...目的探讨曲靖地区初诊2型糖尿病(T2DM)患者糖化血红蛋白(HbA1c)与血脂谱、空腹血糖(FBG)及餐后2 h血糖(2 h PG)水平的关系。方法选择2019年3—12月作者在曲靖市第一人民医院国家住院医师规范化培训期间收治的100例初诊T2DM患者作为研究对象,根据不同HbAlc水平分为HbA1c≤0.08组(18例),0.08<HbA1c≤0.11组(36例)以及HbA1c>0.11组(46例)。采用高效液相色谱(HPLC)检测HbA1c;采用己糖激酶法检测血糖;采用胆固醇氧化酶/苯酚氨基安替比林法(CHOD-PAP)检测总胆固醇(TC);采用甘油磷酸氧化酶法检测三酰甘油(TG);采用直接法检测高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)。比较3组各临床指标的差异;使用Pearson相关性分析方法对HbA1c与血脂谱、FBG以及2 h PG的相关性进行分析。结果随着HbA1c水平升高,3组TG、TC、LDL-C、FBG及2 h PG水平逐渐升高,而HDL-C则呈下降趋势,3组间上述指标比较差异均有统计学意义(均P<0.05)。Pearson相关性分析表明,HbAlc水平与TG、TC、LDL-C、FBG和2 h PG均呈正相关(r值分别为0.41、0.40、0.46、0.36、0.34,P值分别为0.000、0.000、0.000、0.000、0.001),与HDL-C呈负相关(r=-0.33,P=0.001)。结论HbA1c与血脂谱、FBG、2 h PG水平均有相关性,HbA1c可作为预测T2DM患者血脂水平的良好指标。严格控制糖尿病患者的血脂水平及餐前、餐后血糖水平可显著降低心血管并发症的发生风险。展开更多
Background and Aims: Hyperlipidemia is one of clear risk factors of diabetes. Regarding its importance, this study was designed to compare the effects of olive oil and grape seed oil on serum lipids and blood pressure...Background and Aims: Hyperlipidemia is one of clear risk factors of diabetes. Regarding its importance, this study was designed to compare the effects of olive oil and grape seed oil on serum lipids and blood pressure in patients with hyperlipidemia in 2015. Methods and Results: In this clinical trial, 60 patients with hyperlipidemia who met inclusion criteria were recruited. Subjects were randomly assigned 3 groups: 1) consume 20 ml/day refined olive oil;2) consume 20 ml/day grape seed oil;3) the control group received no oil. The study period was six weeks. All participants were under Step I diet. Height and weight measurements were taken by Seca scale. Blood pressure, total cholesterol, high-density lipoprotein, triglyceride and fasting blood sugar were measured at baseline and after 6 weeks by standard methods. Low-density lipoprotein levels were calculated by the Friedewald’s formula. Data were analyzed with ANOVA test in SPSS software version 16.0. Sixty participants (36 female and 24 male) with the average age of 47.5 ± 9 y and the mean body mass index of 31.78 ± 5.41 kg/m2 had completed the study. Olive oil intervention decreased systolic blood pressure significantly compared to grape seed oil group (P = 0.01). Triglyceride was significantly decreased in olive oil and also triglyceride groups (P = 0.02 and 0.004, respectively). Conclusion: Overall, the effects of olive oil and grape seed oil were better than control group. However, we suggest the substitution of dietary lipids with olive oil because of its more beneficial effects. Registration number for clinical trial: IRCT2014070218329N1 registration code in Iran Clinical Trial site.展开更多
文摘目的探讨曲靖地区初诊2型糖尿病(T2DM)患者糖化血红蛋白(HbA1c)与血脂谱、空腹血糖(FBG)及餐后2 h血糖(2 h PG)水平的关系。方法选择2019年3—12月作者在曲靖市第一人民医院国家住院医师规范化培训期间收治的100例初诊T2DM患者作为研究对象,根据不同HbAlc水平分为HbA1c≤0.08组(18例),0.08<HbA1c≤0.11组(36例)以及HbA1c>0.11组(46例)。采用高效液相色谱(HPLC)检测HbA1c;采用己糖激酶法检测血糖;采用胆固醇氧化酶/苯酚氨基安替比林法(CHOD-PAP)检测总胆固醇(TC);采用甘油磷酸氧化酶法检测三酰甘油(TG);采用直接法检测高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)。比较3组各临床指标的差异;使用Pearson相关性分析方法对HbA1c与血脂谱、FBG以及2 h PG的相关性进行分析。结果随着HbA1c水平升高,3组TG、TC、LDL-C、FBG及2 h PG水平逐渐升高,而HDL-C则呈下降趋势,3组间上述指标比较差异均有统计学意义(均P<0.05)。Pearson相关性分析表明,HbAlc水平与TG、TC、LDL-C、FBG和2 h PG均呈正相关(r值分别为0.41、0.40、0.46、0.36、0.34,P值分别为0.000、0.000、0.000、0.000、0.001),与HDL-C呈负相关(r=-0.33,P=0.001)。结论HbA1c与血脂谱、FBG、2 h PG水平均有相关性,HbA1c可作为预测T2DM患者血脂水平的良好指标。严格控制糖尿病患者的血脂水平及餐前、餐后血糖水平可显著降低心血管并发症的发生风险。
文摘Background and Aims: Hyperlipidemia is one of clear risk factors of diabetes. Regarding its importance, this study was designed to compare the effects of olive oil and grape seed oil on serum lipids and blood pressure in patients with hyperlipidemia in 2015. Methods and Results: In this clinical trial, 60 patients with hyperlipidemia who met inclusion criteria were recruited. Subjects were randomly assigned 3 groups: 1) consume 20 ml/day refined olive oil;2) consume 20 ml/day grape seed oil;3) the control group received no oil. The study period was six weeks. All participants were under Step I diet. Height and weight measurements were taken by Seca scale. Blood pressure, total cholesterol, high-density lipoprotein, triglyceride and fasting blood sugar were measured at baseline and after 6 weeks by standard methods. Low-density lipoprotein levels were calculated by the Friedewald’s formula. Data were analyzed with ANOVA test in SPSS software version 16.0. Sixty participants (36 female and 24 male) with the average age of 47.5 ± 9 y and the mean body mass index of 31.78 ± 5.41 kg/m2 had completed the study. Olive oil intervention decreased systolic blood pressure significantly compared to grape seed oil group (P = 0.01). Triglyceride was significantly decreased in olive oil and also triglyceride groups (P = 0.02 and 0.004, respectively). Conclusion: Overall, the effects of olive oil and grape seed oil were better than control group. However, we suggest the substitution of dietary lipids with olive oil because of its more beneficial effects. Registration number for clinical trial: IRCT2014070218329N1 registration code in Iran Clinical Trial site.
