With unprecedented properties and functions,polymer-based hybrid materials hold extremely important position in many fields.Here in this review,we summarized applications of polymer-based hybrid materials toward perso...With unprecedented properties and functions,polymer-based hybrid materials hold extremely important position in many fields.Here in this review,we summarized applications of polymer-based hybrid materials toward personal health.Firstly,theoretical calculation and in-situ visualization used to explore the interfacial interaction and formation of hybrid materials are introduced.Secondly,applications of polymer-based hybrid materials in personal health from proactive protection(anti-bacteria and harmful gas removal),health condition monitoring(breathing and sleep)to disease diagnosis(magnetic resonance imaging),and tissue therapy(dental restoration)are discussed.Additionally,aggregation-induced emission(AIE)organic molecules based optical sensors for personal security and polymer semiconductor for organic thin film transistors are simply discussed.Finally,we present the future tendency for preparing polymer-based hybrid materials that related with personal health.展开更多
Blind source extraction （BSE） is widely used to solve signal mixture problems where there are only a few desired signals. To improve signal extraction performance and expand its application, we develop an adaptive B...Blind source extraction （BSE） is widely used to solve signal mixture problems where there are only a few desired signals. To improve signal extraction performance and expand its application, we develop an adaptive BSE algorithm with an additive noise model. We first present an improved normalized kurtosis as an objective function, which caters for the effect of noise. By combining the objective function and Lagrange multiplier method, we further propose a robust algorithm that can extract the desired signal as the first output signal. Simulations on both synthetic and real biomedical signals demonstrate that such combination improves the extrac- tion performance and has better robustness to the estimation error of normalized kurtosis value in the presence of noise.展开更多
决明(Cassia tora Linn),是豆科决明属一年生亚灌木状草本植物,种子是决明子的常用中药,现代药理研究表明,决明子具有明显的药理作用,决明子提取物(cassia seed extract,CSE)可以有效减轻糖尿病大鼠的心肌缺血/再灌注损伤,其机制可能与...决明(Cassia tora Linn),是豆科决明属一年生亚灌木状草本植物,种子是决明子的常用中药,现代药理研究表明,决明子具有明显的药理作用,决明子提取物(cassia seed extract,CSE)可以有效减轻糖尿病大鼠的心肌缺血/再灌注损伤,其机制可能与降脂作用以及对Akt和ERK1/2信号通路的激活有关。为了考察决明子提取物(CSE)上述生物医学功能。本研究采用力竭运动模型大鼠为研究对象,研究结果显示,CSE预处理可通过提高SOD、GSH和GSH-Px活性、降低MDA水平来抑制力竭运动所致的氧化应激损伤。CSE通过降低Bax/Bcl-2比值,下调cleaved-caspase-3水平来抑制心肌细胞凋亡,从而减轻心肌损伤。本研究还发现CSE通过激活Nrf2/HO1和失活NF-κB信号通路来抑制氧化应激和心肌细胞凋亡。因此,本研究表明CSE可减轻力竭运动引起的氧化应激和细胞凋亡,从而对心肌损伤发挥保护作用。展开更多
姜黄(Curcuma longa L.)是芭蕉目姜科姜黄属多年生草本植物,姜黄素(Curcumin)是从姜黄中提取出来的一种天然酚类物质。研究表明,姜黄具有多种药理和营养特性,如抗氧化、降血压、增强免疫力等。本研究试图以不同年龄段的小鼠为研究对象,...姜黄(Curcuma longa L.)是芭蕉目姜科姜黄属多年生草本植物,姜黄素(Curcumin)是从姜黄中提取出来的一种天然酚类物质。研究表明,姜黄具有多种药理和营养特性,如抗氧化、降血压、增强免疫力等。本研究试图以不同年龄段的小鼠为研究对象,观察从姜黄植物中提取的姜黄素是通过何种途径来参与骨骼肌重建的,深入了解姜黄素的医学生物学功能,为姜黄素的生物化学特性和临床应用提供理论基础。研究结果发现,与空白对照组相比,运动组小鼠和姜黄素添加组小鼠中,成年各组小鼠的体重和骨骼肌重量均高于老年各组小鼠;与成年小鼠相比,老年小鼠骨骼肌组织中MDA和GPX含量均有所增加,而SOD和CAT活性明显降低;MDA和GPX含量均显著下降,而SOD和CAT活性显著增加。总之,本研究结果初步表明姜黄素主要是通过氧化途径来参与骨骼肌重建。展开更多
Blind source extraction （BSE） is particularly at- tractive to solve blind signal mixture problems where only a few source signals are desired. Many existing BSE methods do not take into account the existence of nois...Blind source extraction （BSE） is particularly at- tractive to solve blind signal mixture problems where only a few source signals are desired. Many existing BSE methods do not take into account the existence of noise and can only work well in noise-free environments. In practice, the desired signal is often contaminated by additional noise. Therefore, we try to tackle the problem of noisy component extraction. The reference signal carries enough prior information to dis- tinguish the desired signal from signal mixtures. According to the useful properties of Gaussian moments, we incorporate the reference signal into a negentropy objective function so as to guide the extraction process and develop an improved BSE method. Extensive computer simulations demonstrate its validity in the process of revealing the underlying desired signal.展开更多
基金supported by the National Key Research and Development Program of China(Nos.2021YFA1201301,2021YFA1201300,and 2021YFA1201304)the National Natural Science Foundation of China(Nos.51903042,52103298,51973030,and 22173017)+1 种基金the Science and Technology Commission of Shanghai Municipality(Nos.20JC1414900,21ZR1401400,and 19ZR1470600)the Fundamental Research Funds for the Central Universities(No.2232021A-06).
文摘With unprecedented properties and functions,polymer-based hybrid materials hold extremely important position in many fields.Here in this review,we summarized applications of polymer-based hybrid materials toward personal health.Firstly,theoretical calculation and in-situ visualization used to explore the interfacial interaction and formation of hybrid materials are introduced.Secondly,applications of polymer-based hybrid materials in personal health from proactive protection(anti-bacteria and harmful gas removal),health condition monitoring(breathing and sleep)to disease diagnosis(magnetic resonance imaging),and tissue therapy(dental restoration)are discussed.Additionally,aggregation-induced emission(AIE)organic molecules based optical sensors for personal security and polymer semiconductor for organic thin film transistors are simply discussed.Finally,we present the future tendency for preparing polymer-based hybrid materials that related with personal health.
文摘Blind source extraction （BSE） is widely used to solve signal mixture problems where there are only a few desired signals. To improve signal extraction performance and expand its application, we develop an adaptive BSE algorithm with an additive noise model. We first present an improved normalized kurtosis as an objective function, which caters for the effect of noise. By combining the objective function and Lagrange multiplier method, we further propose a robust algorithm that can extract the desired signal as the first output signal. Simulations on both synthetic and real biomedical signals demonstrate that such combination improves the extrac- tion performance and has better robustness to the estimation error of normalized kurtosis value in the presence of noise.
文摘决明(Cassia tora Linn),是豆科决明属一年生亚灌木状草本植物,种子是决明子的常用中药,现代药理研究表明,决明子具有明显的药理作用,决明子提取物(cassia seed extract,CSE)可以有效减轻糖尿病大鼠的心肌缺血/再灌注损伤,其机制可能与降脂作用以及对Akt和ERK1/2信号通路的激活有关。为了考察决明子提取物(CSE)上述生物医学功能。本研究采用力竭运动模型大鼠为研究对象,研究结果显示,CSE预处理可通过提高SOD、GSH和GSH-Px活性、降低MDA水平来抑制力竭运动所致的氧化应激损伤。CSE通过降低Bax/Bcl-2比值,下调cleaved-caspase-3水平来抑制心肌细胞凋亡,从而减轻心肌损伤。本研究还发现CSE通过激活Nrf2/HO1和失活NF-κB信号通路来抑制氧化应激和心肌细胞凋亡。因此,本研究表明CSE可减轻力竭运动引起的氧化应激和细胞凋亡,从而对心肌损伤发挥保护作用。
文摘姜黄(Curcuma longa L.)是芭蕉目姜科姜黄属多年生草本植物,姜黄素(Curcumin)是从姜黄中提取出来的一种天然酚类物质。研究表明,姜黄具有多种药理和营养特性,如抗氧化、降血压、增强免疫力等。本研究试图以不同年龄段的小鼠为研究对象,观察从姜黄植物中提取的姜黄素是通过何种途径来参与骨骼肌重建的,深入了解姜黄素的医学生物学功能,为姜黄素的生物化学特性和临床应用提供理论基础。研究结果发现,与空白对照组相比,运动组小鼠和姜黄素添加组小鼠中,成年各组小鼠的体重和骨骼肌重量均高于老年各组小鼠;与成年小鼠相比,老年小鼠骨骼肌组织中MDA和GPX含量均有所增加,而SOD和CAT活性明显降低;MDA和GPX含量均显著下降,而SOD和CAT活性显著增加。总之,本研究结果初步表明姜黄素主要是通过氧化途径来参与骨骼肌重建。
文摘Blind source extraction （BSE） is particularly at- tractive to solve blind signal mixture problems where only a few source signals are desired. Many existing BSE methods do not take into account the existence of noise and can only work well in noise-free environments. In practice, the desired signal is often contaminated by additional noise. Therefore, we try to tackle the problem of noisy component extraction. The reference signal carries enough prior information to dis- tinguish the desired signal from signal mixtures. According to the useful properties of Gaussian moments, we incorporate the reference signal into a negentropy objective function so as to guide the extraction process and develop an improved BSE method. Extensive computer simulations demonstrate its validity in the process of revealing the underlying desired signal.
