The present study was designed to prepare and compare bio-adhesive pellets of panax notoginseng saponins(PNS) with hydroxy propyl methyl cellulose(HPMC), chitosan, and chitosan : carbomer, explore the influence of dif...The present study was designed to prepare and compare bio-adhesive pellets of panax notoginseng saponins(PNS) with hydroxy propyl methyl cellulose(HPMC), chitosan, and chitosan : carbomer, explore the influence of different bio-adhesive materials on pharmacokinetics behaviors of PNSbio-adhesive pellets, and evaluate the correlation between in vivo absorption and in vitro release(IVIVC). In order to predict the in vivo concentration-time profile by the in vitro release data of bio-adhesive pellets, the release experiment was performed using the rotating basket method in p H 6.8 phosphate buffer. The PNS concentrations in rat plasma were analyzed by HPLC-MS-MS method and the relative bioavailability and other pharmacokinetic parameters were estimated using Kinetica4.4 pharmacokinetic software. Numerical deconvolution method was used to evaluate IVIVC. Our results indicated that, compared with ordinary pellets, PNS bio-adhesive pellets showed increased oral bioavailability by 1.45 to 3.20 times, increased Cmax, and extended MRT. What's more, the release behavior of drug in HPMC pellets was shown to follow a Fickian diffusion mechanism, a synergetic function of diffusion and skeleton corrosion. The in vitro release and the in vivo biological activity had a good correlation, demonstrating that the PNS bio-adhesive pellets had a better sustained release. Numerical deconvolution technique showed the advantage in evaluation of IVIVC for self-designed bio-adhesive pellets with HPMC. In conclusion, the in vitro release data of bio-adhesive pellets with HPMC can predict its concentration-time profile in vivo.展开更多
The remarkable functionality of biological systems in detecting and adapting to various environmental conditions has inspired the design of the latest electronics and robots with advanced features.This review focuses ...The remarkable functionality of biological systems in detecting and adapting to various environmental conditions has inspired the design of the latest electronics and robots with advanced features.This review focuses on intelligent bio-inspired strategies for developing soft bioelectronics and robotics that can accommodate nanocomposite adhesives and integrate them into biological surfaces.The underlying principles of the material and structural design of nanocomposite adhesives were investigated for practical applications with excellent functionalities,such as soft skin-attachable health care sensors,highly stretchable adhesive electrodes,switchable adhesion,and untethered soft robotics.In addition,we have discussed recent progress in the development of effective fabrication methods for micro/nanostructures for integration into devices,presenting the current challenges and prospects.展开更多
Wound abnormalities such as secondary wound laceration and inflammation are common postoperative health hazards during clinical procedures.The continuous treatment,healing induction,and real-time visualization of woun...Wound abnormalities such as secondary wound laceration and inflammation are common postoperative health hazards during clinical procedures.The continuous treatment,healing induction,and real-time visualization of wound status and complications,including wound re-tearing,inflammation,and morphology,are key focal points for comprehensive healthcare.Herein,an on-demand quadruple energy dissipative strategy was proposed for the nanoengineering of a physically and chemically synergistic double-layer gelatin-based bio-adhesive(DLGel)by combining a multi-network adhesive layer and a versatile electroactive energy dissipative layer based on contrivable interlocking micro-pillar arrays and crosslinked polymer chains.The subtly multiple energy dissipation designs enable DLGel with robust adhesive strength to omnipotently wet and dynamic tissue,providing a basis for reliable wound closure.DLGel achieves comprehensive wound-healing induction through electrical stimulation and possesses reversible underwater light/thermal adhesion,excellent hemostatic performance,outstanding antimicrobial properties,and self-repair capability.Furthermore,a novel deep-learning strategy is creatively established to respond to mechanical deformation due to wound anomalies.This strategy translates biological information into visual graphics,providing real-time early warning and assessment of postoperative wound-abnormality/-morphology,such as laceration,inflammation,and necrosis.Therefore,DLGel and its associated signal collection and processing protocol enable the integration of reliable wound closure,wound healing,and real-time postoperative wound-status warning and assessment within the unobservable and undetectable“black box”regions in a context of non-clinical comprehensive therapy.展开更多
The dynamic structures of extracellular matrix regulate cell behaviors by providing three-dimension ecological niche and mechanical cues.Under the progress of both surface patterning and biomaterials,the cues of micro...The dynamic structures of extracellular matrix regulate cell behaviors by providing three-dimension ecological niche and mechanical cues.Under the progress of both surface patterning and biomaterials,the cues of micro-and nanoscale topography on microstructural scaffold biomaterials are increasingly recognized as decisive factors of biomimetic materials.In this review,we provide an overview of the recent progress of biomimetic microstructured scaffolds,including advances in their biomimetic manufacturing technology,functionality,potential applications and future challenges.We highlight recent progress in the fabrication of microstructured scaffold materials with various biological and physicochemical characteristics of native extracellular matrix.The recent key advances of microstructured scaffold for tissue engineering,bio-adhesive,antibacterial and biosensing applications were offered.Eventually,we summarize by offering our perspective on this fast-growing field.展开更多
This work was aim to prepare a packing material from natural resources to reduce the environment pollution caused by plastics.Four bio-adhesives(guar gum,sodium alginate,agar and chitosan)were combined with lotus leaf...This work was aim to prepare a packing material from natural resources to reduce the environment pollution caused by plastics.Four bio-adhesives(guar gum,sodium alginate,agar and chitosan)were combined with lotus leaf fibers to prepare degradable composites,respectively.The mechanical properties,moisture absorption profiles and the thermal conductivity of the composites were studied and the cross section morphology and the thermal properties of the composites were analyzed.The Fourier-transform infrared spectroscopy(FTIR)results showed that the polar groups such as–OH and–COO^(–)in bio-adhesives can form hydrogen bond with–OH in lotus leaf fibers to connect the two components.The combination of agar and lotus leaf fiber was good,and their composite had the best mechanical properties,with the tensile strength,flexural strength and impact strength of 2.05,5.9 MPa and 4.29 kJ·m_(−2),respectively,and the composite had a low moisture absorption profile,and the equilibrium moisture absorption rate was 32.32%.The lotus leaf fiber/agar composite(LAC)had an excellent comprehensive performance and it was non-toxic,degradable and thermal insulating,which indicated that it had the potential to use in packaging field to substitute plastics.展开更多
Some insects and animals, such as bugs, grasshoppers and tree frogs, realize their efficient adhesion mechanism to glass surface, wall and ceiling by injecting a wetting liquid thin film into the pad-substrate contact...Some insects and animals, such as bugs, grasshoppers and tree frogs, realize their efficient adhesion mechanism to glass surface, wall and ceiling by injecting a wetting liquid thin film into the pad-substrate contact area. Their ability to control adhesion (attaching or detaching from a surface) is in many cases connected to the contact geometry and surface patterns of their attachment pads. This paper focuses on the dependence of the capillary adhesion (wet adhesion) on the micro patterns of the bio-adhesive pads. The objective is to reveal the possible mechanism for a bio-adhesive pad to control capillary force through adjusting its micro-scale surface pattern and topography. A capillary adhesion force model is built up taking account of the combined role of micro-dimple geometry as well as the wetting behavior of the confined liquid thin film. Calculated results of the apparent contact angle on the regularly micro-dimpled surfaces are compared with and in good agreement with the experimental measurements. Simulation of the capillary adhesion force reveals that it is controllable in a large mag- nitude by adjusting a dimensionless surface pattern parameter k defined as a/(a+b), where a is the dia- meter of micro dimple, and (a+b) is the side length of one pattern cell. When adjusting the parameter k more than 0.75, the capillary adhesion force could be switchable from attractive to repulsive. This effect of micro patterns on the interfacial capillary force is proved to be dominant when the pad-substrate clearance decreases to the nano/micrometer scale. These results indicate that a controllable and switchable capillary adhesive mechanism might be utilized by a living insect or animal to realize its stable adhesion and quick releasing movement through adjusting the micro-pattern topography of its bio-adhesive pad.展开更多
基金supported by the National Natural Science Foundation of China(No.81274094)
文摘The present study was designed to prepare and compare bio-adhesive pellets of panax notoginseng saponins(PNS) with hydroxy propyl methyl cellulose(HPMC), chitosan, and chitosan : carbomer, explore the influence of different bio-adhesive materials on pharmacokinetics behaviors of PNSbio-adhesive pellets, and evaluate the correlation between in vivo absorption and in vitro release(IVIVC). In order to predict the in vivo concentration-time profile by the in vitro release data of bio-adhesive pellets, the release experiment was performed using the rotating basket method in p H 6.8 phosphate buffer. The PNS concentrations in rat plasma were analyzed by HPLC-MS-MS method and the relative bioavailability and other pharmacokinetic parameters were estimated using Kinetica4.4 pharmacokinetic software. Numerical deconvolution method was used to evaluate IVIVC. Our results indicated that, compared with ordinary pellets, PNS bio-adhesive pellets showed increased oral bioavailability by 1.45 to 3.20 times, increased Cmax, and extended MRT. What's more, the release behavior of drug in HPMC pellets was shown to follow a Fickian diffusion mechanism, a synergetic function of diffusion and skeleton corrosion. The in vitro release and the in vivo biological activity had a good correlation, demonstrating that the PNS bio-adhesive pellets had a better sustained release. Numerical deconvolution technique showed the advantage in evaluation of IVIVC for self-designed bio-adhesive pellets with HPMC. In conclusion, the in vitro release data of bio-adhesive pellets with HPMC can predict its concentration-time profile in vivo.
基金supported by the R&D program of the Ministry of Trade,Industry&Energy(No.20016252,Development of a hybrid-type high-performance multimodal electronic skin sensor and a scalable module for robot manipulation)supported by the National Research Foundation of Korea(NRF)grant funded by the Korean government(Ministry of Science and ICT,MSIT)(No.RS-2023-00214236)+1 种基金the National Research Council of Science&Technology(NST)grant by the Korea government(MSIT)(No.CRC230231-000)the Korea Evaluation Institute of Industrial Technology(KEIT)grant funded by the Korean government(MOTIE,No.RS-2022-00154781,Development of large-area wafer-level flexible/stretchable hybrid sensor platform technology for form factor-free highly integrated convergence sensors).
文摘The remarkable functionality of biological systems in detecting and adapting to various environmental conditions has inspired the design of the latest electronics and robots with advanced features.This review focuses on intelligent bio-inspired strategies for developing soft bioelectronics and robotics that can accommodate nanocomposite adhesives and integrate them into biological surfaces.The underlying principles of the material and structural design of nanocomposite adhesives were investigated for practical applications with excellent functionalities,such as soft skin-attachable health care sensors,highly stretchable adhesive electrodes,switchable adhesion,and untethered soft robotics.In addition,we have discussed recent progress in the development of effective fabrication methods for micro/nanostructures for integration into devices,presenting the current challenges and prospects.
基金supported by Fellowship of China Postdoctoral Science Foundation(No.2023M732159)the National Natural Science Foundation of China(Nos.22308209 ,2207081675)+1 种基金Key R&D Program of Shaanxi Province(No.2022GY-272)Young Talent Support Program Project of Shaanxi University Science and Technology Association(No.20200424).
文摘Wound abnormalities such as secondary wound laceration and inflammation are common postoperative health hazards during clinical procedures.The continuous treatment,healing induction,and real-time visualization of wound status and complications,including wound re-tearing,inflammation,and morphology,are key focal points for comprehensive healthcare.Herein,an on-demand quadruple energy dissipative strategy was proposed for the nanoengineering of a physically and chemically synergistic double-layer gelatin-based bio-adhesive(DLGel)by combining a multi-network adhesive layer and a versatile electroactive energy dissipative layer based on contrivable interlocking micro-pillar arrays and crosslinked polymer chains.The subtly multiple energy dissipation designs enable DLGel with robust adhesive strength to omnipotently wet and dynamic tissue,providing a basis for reliable wound closure.DLGel achieves comprehensive wound-healing induction through electrical stimulation and possesses reversible underwater light/thermal adhesion,excellent hemostatic performance,outstanding antimicrobial properties,and self-repair capability.Furthermore,a novel deep-learning strategy is creatively established to respond to mechanical deformation due to wound anomalies.This strategy translates biological information into visual graphics,providing real-time early warning and assessment of postoperative wound-abnormality/-morphology,such as laceration,inflammation,and necrosis.Therefore,DLGel and its associated signal collection and processing protocol enable the integration of reliable wound closure,wound healing,and real-time postoperative wound-status warning and assessment within the unobservable and undetectable“black box”regions in a context of non-clinical comprehensive therapy.
文摘The dynamic structures of extracellular matrix regulate cell behaviors by providing three-dimension ecological niche and mechanical cues.Under the progress of both surface patterning and biomaterials,the cues of micro-and nanoscale topography on microstructural scaffold biomaterials are increasingly recognized as decisive factors of biomimetic materials.In this review,we provide an overview of the recent progress of biomimetic microstructured scaffolds,including advances in their biomimetic manufacturing technology,functionality,potential applications and future challenges.We highlight recent progress in the fabrication of microstructured scaffold materials with various biological and physicochemical characteristics of native extracellular matrix.The recent key advances of microstructured scaffold for tissue engineering,bio-adhesive,antibacterial and biosensing applications were offered.Eventually,we summarize by offering our perspective on this fast-growing field.
基金This work was financially supported by the Regional Cooperative Innovation in Autonomous Region(2019E0241),China.
文摘This work was aim to prepare a packing material from natural resources to reduce the environment pollution caused by plastics.Four bio-adhesives(guar gum,sodium alginate,agar and chitosan)were combined with lotus leaf fibers to prepare degradable composites,respectively.The mechanical properties,moisture absorption profiles and the thermal conductivity of the composites were studied and the cross section morphology and the thermal properties of the composites were analyzed.The Fourier-transform infrared spectroscopy(FTIR)results showed that the polar groups such as–OH and–COO^(–)in bio-adhesives can form hydrogen bond with–OH in lotus leaf fibers to connect the two components.The combination of agar and lotus leaf fiber was good,and their composite had the best mechanical properties,with the tensile strength,flexural strength and impact strength of 2.05,5.9 MPa and 4.29 kJ·m_(−2),respectively,and the composite had a low moisture absorption profile,and the equilibrium moisture absorption rate was 32.32%.The lotus leaf fiber/agar composite(LAC)had an excellent comprehensive performance and it was non-toxic,degradable and thermal insulating,which indicated that it had the potential to use in packaging field to substitute plastics.
基金Supported by the National Natural Science Foundation of China (Grant Nos. 50575123, 50730007)PPP Project from CSC and DAADGerman Research Foundation (DFG) (Grant No. SFB622) (Y.H. Liu and S.I.-U. Ahmed)
文摘Some insects and animals, such as bugs, grasshoppers and tree frogs, realize their efficient adhesion mechanism to glass surface, wall and ceiling by injecting a wetting liquid thin film into the pad-substrate contact area. Their ability to control adhesion (attaching or detaching from a surface) is in many cases connected to the contact geometry and surface patterns of their attachment pads. This paper focuses on the dependence of the capillary adhesion (wet adhesion) on the micro patterns of the bio-adhesive pads. The objective is to reveal the possible mechanism for a bio-adhesive pad to control capillary force through adjusting its micro-scale surface pattern and topography. A capillary adhesion force model is built up taking account of the combined role of micro-dimple geometry as well as the wetting behavior of the confined liquid thin film. Calculated results of the apparent contact angle on the regularly micro-dimpled surfaces are compared with and in good agreement with the experimental measurements. Simulation of the capillary adhesion force reveals that it is controllable in a large mag- nitude by adjusting a dimensionless surface pattern parameter k defined as a/(a+b), where a is the dia- meter of micro dimple, and (a+b) is the side length of one pattern cell. When adjusting the parameter k more than 0.75, the capillary adhesion force could be switchable from attractive to repulsive. This effect of micro patterns on the interfacial capillary force is proved to be dominant when the pad-substrate clearance decreases to the nano/micrometer scale. These results indicate that a controllable and switchable capillary adhesive mechanism might be utilized by a living insect or animal to realize its stable adhesion and quick releasing movement through adjusting the micro-pattern topography of its bio-adhesive pad.
