Hepatobiliary cancers are highly lethal cancers that comprise a spectrum of invasive carcinomas originating in the liver hepatocellular carcinoma,the bile ducts intrahepatic cholangiocarcinoma and extrahepaticcholangi...Hepatobiliary cancers are highly lethal cancers that comprise a spectrum of invasive carcinomas originating in the liver hepatocellular carcinoma,the bile ducts intrahepatic cholangiocarcinoma and extrahepaticcholangiocarcinoma,the gallbladder and the ampulla of Vater(collectively known as biliary tract cancers).These tumors account for approximately 13% of all annual cancer-related deaths worldwide and for 10%-20% of deaths from hepatobiliary malignancies.Cholangiocarcinoma(CCA) is a devastating disease that displays a poor survival rate for which few therapeutic options are available.Population genetics,geographical and environmental factors,cholelithiasis,obesity,parity,and endemic infection with liver flukes have been identified as risk factors that influence the development of biliary tract tumors.Other important factors affecting the carcinogenesis of these tumors include chronic inflammation,obstruction of the bile ducts,and impaired bile flow.It has been suggested that CCA is caused by infection with Helicobacter species,such as Helicobacter bilis and Helicobacter hepaticus,in a manner that is similar to the reported role of Helicobacter pylori in distal gastric cancer.Due to the difficulty in culturing these Helicobacter species,molecular methods,such as polymerase chain reaction and sequencing,or immunologic assays have become the methods of choice for diagnosis.However,clinical studies of benign or malignant biliary tract diseases revealed remarkable variability in the methods and the findings,and the use of uniform and validated techniques is needed.展开更多
By using the dataset of CMA-STI Tropical Cyclone Optimal Tracks, NCEP/NCAR reanalysis and intensive surface observations, a study is performed of the influences of a low-latitude monsoon surge on the longer persistenc...By using the dataset of CMA-STI Tropical Cyclone Optimal Tracks, NCEP/NCAR reanalysis and intensive surface observations, a study is performed of the influences of a low-latitude monsoon surge on the longer persistence and increase in torrential rains from the landing tropical storm Bilis. Results suggest that the southwest monsoon was anomalously active after Bilis came ashore. The westerly winds in Bilis's south side might give rise to the poleward movement of the SW monsoon, thus enlarging the pressure gradient between Bilis and the anticyclonic circulation to the south with the result of greatly intensified SW monsoon, which fueled plentiful water vapor, heat and momentum into the declining Bilis and allowed its long stay over land instead of erosion and disappearance. Before Bilis's landfall, the 2006 East Asian monsoon surge, characterized by the atmospheric ISO, experienced remarkable northward propagation. After landfall, the strong surge and powerful low frequency vapor convergence were just on the south side of Bilis, resulting in sharply increased rainfall. In addition, a broad belt of high-valued vapor fluxes extended from the eastern Arabian Sea via the Bay of Bengal, Indochina Peninsula and the South China Sea into the south of China. The belt was linked with the SW monsoon surge forming a moist tongue stretching from the Bay of Bengal to the south of China, which supplied continuously abundant vapor for Bilis along with the surge propagating poleward.展开更多
The NCEP/NCAR reanalysis, Japan Meteorological Agency(JMA) tropical cyclone tracks and intensive surface observations are used to diagnose the features of moisture transport of tropical storm Bilis(No. 0604), which is...The NCEP/NCAR reanalysis, Japan Meteorological Agency(JMA) tropical cyclone tracks and intensive surface observations are used to diagnose the features of moisture transport of tropical storm Bilis(No. 0604), which is simulated by the WRF(weather research and forecasting) mesoscale numerical model. It is shown that the Bilis was linked with the moisture channel in the lower latitudes after its landing. Meanwhile, the cross-equatorial flows over 80°-100°E and Somali were active and brought abundant water vapor into the tropical storm, facilitating the maintenance of the landing storm with intensified heavy rainfall along its path. The simulation suggested that the decreased water vapor from lower latitudes prevents the maintenance of Bilis and the development of rainfall. While the cross-equatorial flows over 80°-100°E and Somali were in favor of keeping the cyclonic circulation over land. If the moisture supply fro m the Somali jet stream was reduced, the strength and area of heavy rainfall in tropical cyclone would be remarkably weakened. Consequently, the decreased water vapor from lower latitudes can remarkably suppress the deep convection in tropical storm, then Bilis was damped without the persistent energy support and the rainfall was diminished accordingly.展开更多
利用中尺度数值模式WRF(weather research and forecasting model)对2006年7月16—17日在我国华南沿海地区引发强降水的中尺度对流系统(mesoscale convective systems,MCS)活动进行了数值模拟,并结合观测资料对此次过程进行分析。结果表...利用中尺度数值模式WRF(weather research and forecasting model)对2006年7月16—17日在我国华南沿海地区引发强降水的中尺度对流系统(mesoscale convective systems,MCS)活动进行了数值模拟,并结合观测资料对此次过程进行分析。结果表明,1)此次MCS活动与0604号强热带风暴"碧利斯"减弱而成的热带低气压及西南季风密切相关。热低压为MCS的发生提供了动力抬升条件,西南季风则承担了输送水汽的角色,二者的持续结合,使华南大部地区中尺度对流系统不断发生和发展,形成强降水。2)该MCS具有明显的不对称结构,云体越向上越向南部伸展,云系主要分布在热低压的南部,呈东北—西南走向的带状。3)模式对此次MCS强降水过程的模拟效果较好,客观地反映了此次MCS的发展演变及雨带的分布状况。4)在广西境内的中尺度对流云团中云水含量较少,冰相粒子的比含水量值很大,主要的降水机制为冰晶降水机制。展开更多
We diagnose characteristics of the quasi-balanced flow and secondary circulation（SC） of tropical storm Bilis（2006） using the potential vorticity（PV）-ω inversion method.We further analyze how secondary steering ...We diagnose characteristics of the quasi-balanced flow and secondary circulation（SC） of tropical storm Bilis（2006） using the potential vorticity（PV）-ω inversion method.We further analyze how secondary steering flows associated with mesoscale convective systems affected the track of tropical storm Bilis after it made landfall.The quasi-balanced asymmetric and axisymmetric circulation structures of tropical storm Bilis are represented well by the PV-w inversion.The magnitude of the nonlinear quasi-balanced vertical velocity is approximately 75%of the magnitude simulated using the Weather Research and Forecasting（WRF） model.The SC of Bilis（2006） contained two strong regions of ascending motion,both of which were located in the southwest quadrant of the storm.The first（150-200 km southwest of the storm center） corresponded to the eyewall region,while the second（approximately 400 km southwest of the storm center） corresponded to latent heat release associated with strong precipitation in major spiral rainbands.The SC was very weak in the northeast quadrant（the upshear direction）.Dynamical processes related to the environmental vertical wind shear produced an SC that partially offset the destructive effects of the environmental vertical wind shear（by 20%-25%）.This SC consisted of upward motion in the southwest quadrant and subsidence in the northeast quadrant,with airflow oriented from southwest to northeast at high altitudes and from northeast to southwest at lower levels.The inverted secondary zonal and meridional steering flows associated with continuous asymmetric mesoscale convective systems were about-2.14 and-0.7 m s^（-1）,respectively.These steering flows contributed substantially to the zonal（66.15%） and meridional（33.98%） motion of the storm at 0000 UTC15 July 2006.The secondary steering flow had a significant influence on changing the track of Bilis from southward to northward.The direction of the large-scale meridional steering flow（3.02 m s^（-1）） was 展开更多
Bilis (0604) is a strong tropical storm that sustained over land for a long time, bringing torrential rain. With conventional observation data, radar data and infrared satellite imagery, Mesoscale Convective Systems (...Bilis (0604) is a strong tropical storm that sustained over land for a long time, bringing torrential rain. With conventional observation data, radar data and infrared satellite imagery, Mesoscale Convective Systems (MCSs) are found to form and develop successively, which cause torrential rain. Then numerical simulation is conducted using MM5 to simulate a 66-h post-landfall process. The simulated distribution and intensity of precipitation match the observation well. With the simulated result, the characteristics and process of MCS development are analyzed with the finding that the convergence of the tropical depression and South China Sea (SCS) summer monsoon over The south of China causes the formation of a mesoscale vortex, mesoscale convergence center and mesoscale convergence line, which are favorable to the development and sustaining of the MCSs. A sensitivity experiment indicates that the SCS summer monsoon transports unstable energy and water vapor continuously, which is of vital importance to rainstorms.展开更多
文摘Hepatobiliary cancers are highly lethal cancers that comprise a spectrum of invasive carcinomas originating in the liver hepatocellular carcinoma,the bile ducts intrahepatic cholangiocarcinoma and extrahepaticcholangiocarcinoma,the gallbladder and the ampulla of Vater(collectively known as biliary tract cancers).These tumors account for approximately 13% of all annual cancer-related deaths worldwide and for 10%-20% of deaths from hepatobiliary malignancies.Cholangiocarcinoma(CCA) is a devastating disease that displays a poor survival rate for which few therapeutic options are available.Population genetics,geographical and environmental factors,cholelithiasis,obesity,parity,and endemic infection with liver flukes have been identified as risk factors that influence the development of biliary tract tumors.Other important factors affecting the carcinogenesis of these tumors include chronic inflammation,obstruction of the bile ducts,and impaired bile flow.It has been suggested that CCA is caused by infection with Helicobacter species,such as Helicobacter bilis and Helicobacter hepaticus,in a manner that is similar to the reported role of Helicobacter pylori in distal gastric cancer.Due to the difficulty in culturing these Helicobacter species,molecular methods,such as polymerase chain reaction and sequencing,or immunologic assays have become the methods of choice for diagnosis.However,clinical studies of benign or malignant biliary tract diseases revealed remarkable variability in the methods and the findings,and the use of uniform and validated techniques is needed.
基金National Basic Research Program of China (973 Program, 2009CB421505)National Key Technology R&D Program (2007BAC29B02)Qing Lan Project of Jiangsu Province
文摘By using the dataset of CMA-STI Tropical Cyclone Optimal Tracks, NCEP/NCAR reanalysis and intensive surface observations, a study is performed of the influences of a low-latitude monsoon surge on the longer persistence and increase in torrential rains from the landing tropical storm Bilis. Results suggest that the southwest monsoon was anomalously active after Bilis came ashore. The westerly winds in Bilis's south side might give rise to the poleward movement of the SW monsoon, thus enlarging the pressure gradient between Bilis and the anticyclonic circulation to the south with the result of greatly intensified SW monsoon, which fueled plentiful water vapor, heat and momentum into the declining Bilis and allowed its long stay over land instead of erosion and disappearance. Before Bilis's landfall, the 2006 East Asian monsoon surge, characterized by the atmospheric ISO, experienced remarkable northward propagation. After landfall, the strong surge and powerful low frequency vapor convergence were just on the south side of Bilis, resulting in sharply increased rainfall. In addition, a broad belt of high-valued vapor fluxes extended from the eastern Arabian Sea via the Bay of Bengal, Indochina Peninsula and the South China Sea into the south of China. The belt was linked with the SW monsoon surge forming a moist tongue stretching from the Bay of Bengal to the south of China, which supplied continuously abundant vapor for Bilis along with the surge propagating poleward.
基金Major Program of the Natural Science Researches for Colleges and Universities in Jiangsu Province(14KJA170004)'333'Project of Jiangsu ProvinceNational Natural Science Foundation of China(41575081,41175061)
文摘The NCEP/NCAR reanalysis, Japan Meteorological Agency(JMA) tropical cyclone tracks and intensive surface observations are used to diagnose the features of moisture transport of tropical storm Bilis(No. 0604), which is simulated by the WRF(weather research and forecasting) mesoscale numerical model. It is shown that the Bilis was linked with the moisture channel in the lower latitudes after its landing. Meanwhile, the cross-equatorial flows over 80°-100°E and Somali were active and brought abundant water vapor into the tropical storm, facilitating the maintenance of the landing storm with intensified heavy rainfall along its path. The simulation suggested that the decreased water vapor from lower latitudes prevents the maintenance of Bilis and the development of rainfall. While the cross-equatorial flows over 80°-100°E and Somali were in favor of keeping the cyclonic circulation over land. If the moisture supply fro m the Somali jet stream was reduced, the strength and area of heavy rainfall in tropical cyclone would be remarkably weakened. Consequently, the decreased water vapor from lower latitudes can remarkably suppress the deep convection in tropical storm, then Bilis was damped without the persistent energy support and the rainfall was diminished accordingly.
文摘利用中尺度数值模式WRF(weather research and forecasting model)对2006年7月16—17日在我国华南沿海地区引发强降水的中尺度对流系统(mesoscale convective systems,MCS)活动进行了数值模拟,并结合观测资料对此次过程进行分析。结果表明,1)此次MCS活动与0604号强热带风暴"碧利斯"减弱而成的热带低气压及西南季风密切相关。热低压为MCS的发生提供了动力抬升条件,西南季风则承担了输送水汽的角色,二者的持续结合,使华南大部地区中尺度对流系统不断发生和发展,形成强降水。2)该MCS具有明显的不对称结构,云体越向上越向南部伸展,云系主要分布在热低压的南部,呈东北—西南走向的带状。3)模式对此次MCS强降水过程的模拟效果较好,客观地反映了此次MCS的发展演变及雨带的分布状况。4)在广西境内的中尺度对流云团中云水含量较少,冰相粒子的比含水量值很大,主要的降水机制为冰晶降水机制。
基金Supported by the National(Key)Basic Research and Development(973)Program of China(2009CB421503)International Cooperating Program of Science and Technology(2010DFA24650)+1 种基金National Natural Science Foundation of China(41375098 and 41175061)the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)
文摘We diagnose characteristics of the quasi-balanced flow and secondary circulation（SC） of tropical storm Bilis（2006） using the potential vorticity（PV）-ω inversion method.We further analyze how secondary steering flows associated with mesoscale convective systems affected the track of tropical storm Bilis after it made landfall.The quasi-balanced asymmetric and axisymmetric circulation structures of tropical storm Bilis are represented well by the PV-w inversion.The magnitude of the nonlinear quasi-balanced vertical velocity is approximately 75%of the magnitude simulated using the Weather Research and Forecasting（WRF） model.The SC of Bilis（2006） contained two strong regions of ascending motion,both of which were located in the southwest quadrant of the storm.The first（150-200 km southwest of the storm center） corresponded to the eyewall region,while the second（approximately 400 km southwest of the storm center） corresponded to latent heat release associated with strong precipitation in major spiral rainbands.The SC was very weak in the northeast quadrant（the upshear direction）.Dynamical processes related to the environmental vertical wind shear produced an SC that partially offset the destructive effects of the environmental vertical wind shear（by 20%-25%）.This SC consisted of upward motion in the southwest quadrant and subsidence in the northeast quadrant,with airflow oriented from southwest to northeast at high altitudes and from northeast to southwest at lower levels.The inverted secondary zonal and meridional steering flows associated with continuous asymmetric mesoscale convective systems were about-2.14 and-0.7 m s^（-1）,respectively.These steering flows contributed substantially to the zonal（66.15%） and meridional（33.98%） motion of the storm at 0000 UTC15 July 2006.The secondary steering flow had a significant influence on changing the track of Bilis from southward to northward.The direction of the large-scale meridional steering flow（3.02 m s^（-1）） was
基金Experiement on the coupling of typhoons, waves and storm surges in the South China Sea and estimation of typhoon-inflicted disasters,a project from the Research Foundation for Tropical and Marine Meteorological Sciencea project from the Natural Science Foundation of China (40333026)
文摘Bilis (0604) is a strong tropical storm that sustained over land for a long time, bringing torrential rain. With conventional observation data, radar data and infrared satellite imagery, Mesoscale Convective Systems (MCSs) are found to form and develop successively, which cause torrential rain. Then numerical simulation is conducted using MM5 to simulate a 66-h post-landfall process. The simulated distribution and intensity of precipitation match the observation well. With the simulated result, the characteristics and process of MCS development are analyzed with the finding that the convergence of the tropical depression and South China Sea (SCS) summer monsoon over The south of China causes the formation of a mesoscale vortex, mesoscale convergence center and mesoscale convergence line, which are favorable to the development and sustaining of the MCSs. A sensitivity experiment indicates that the SCS summer monsoon transports unstable energy and water vapor continuously, which is of vital importance to rainstorms.
