目的:通过观察运动疲劳后大鼠初级运动皮层M1-纹状体通路局部场电位(Local field potential,LFPs)相位同步振荡活动,结合DA信号系统在运动疲劳后代谢表达变化,探讨皮层-纹状体通路电信号编码在运动疲劳中枢调控中的机制及其与黑质-纹状...目的:通过观察运动疲劳后大鼠初级运动皮层M1-纹状体通路局部场电位(Local field potential,LFPs)相位同步振荡活动,结合DA信号系统在运动疲劳后代谢表达变化,探讨皮层-纹状体通路电信号编码在运动疲劳中枢调控中的机制及其与黑质-纹状体DA系统的协同作用。方法:采用Wistar大鼠建立运动疲劳模型,分为对照组(CG),7天力竭运动即刻组(7FG)以及7天重复力竭运动24 h恢复组(24RG)。采用在体多通道电生理同步记录技术,结合实时视频录像观察M1及纹状体LFPs电振荡活动,分析皮层M1-纹状体同步振荡的相干性;采用免疫组化检测纹状体背外侧区DA受体及相关转运体蛋白在运动疲劳前后的表达。结果:1)与CG组相比,7FG组皮层M1区及纹状体α及β振荡增强(P<0.05),恢复24 h后较7FG组PSD值显著下降(P<0.05),且皮层M1-纹状体α及β振荡相干系数变大、同步性增强(P<0.05);2)与7FG组相比,24RG组相干系数及STWA比率均显著下降(P<0.05);3)与CG组相比,7FG组纹状体背外侧区D2DR表达降低,VMAT2表达上调且差异具有显著性(P<0.05);4)与7FG组相比,24RG组背外侧纹状体区D1DR表达显著降低(P<0.05)。结论:运动疲劳后,D2DR减少可能是导致突触后致密物厚度变化的原因之一,造成纹状体GABA能活动增强,使纹状体电活动增强,反馈至皮层影响皮层综合信号的输出,进而影响大鼠行为活动能力。表明皮层M1和纹状体脑区之间同步振荡活动的改变可能是运动疲劳症状产生的原因之一,且D2DR作为黑质-纹状体DA信号系统的关键受体,可作为改善运动疲劳的干预靶点。展开更多
Parkinson’s disease(PD)is characterized by pathological spontaneous beta oscillations(13 Hz-35 Hz)often observed in basal ganglia(BG)composed of subthalamic nucleus(STN)and globus pallidus(GPe)populations.From the vi...Parkinson’s disease(PD)is characterized by pathological spontaneous beta oscillations(13 Hz-35 Hz)often observed in basal ganglia(BG)composed of subthalamic nucleus(STN)and globus pallidus(GPe)populations.From the viewpoint of dynamics,the spontaneous oscillations are related to limit cycle oscillations in a nonlinear system;here we employ the bifurcation analysis method to elucidate the generating mechanism of the pathological spontaneous beta oscillations underlined by coupling strengths and intrinsic properties of the STN-GPe circuit model.The results reveal that the increase of inter-coupling strength between STN and GPe populations induces the beta oscillations to be generated spontaneously,and causes the oscillation frequency to decrease.However,the increase of intra-coupling(self-feedback)strength of GPe can prevent the model from generating the oscillations,and dramatically increase the oscillation frequency.We further provide a theoretical explanation for the role played by the inter-coupling strength of GPe population in the generation and regulation of the oscillations.Furthermore,our study reveals that the intra-coupling strength of the GPe population provides a switching mechanism on the generation of the abnormal beta oscillations:for small value of the intra-coupling strength,STN population plays a dominant role in inducing the beta oscillations;while for its large value,the GPe population mainly determines the generation of this oscillation.展开更多
Exploring neural markers that predict trust behavior may help us to identify the cognitive process underlying trust decisions and to develop a new approach to promote interpersonal trust.It remains unknown how trust b...Exploring neural markers that predict trust behavior may help us to identify the cognitive process underlying trust decisions and to develop a new approach to promote interpersonal trust.It remains unknown how trust behavior may be predicted early in the decision process.We used electrophysiology to sample the brain activity while participants played the role of trustor in an iterative trust game.The results showed that during the trust generation stage,the trust condition led to higher frontocentral beta band activity related to cognitive inhibition compared to the distrust condition(item level).Moreover,individuals with higher frontocentral beta band activity were more likely to perform trust choices at the single-trial level(individual level).Furthermore,after receiving reciprocity feedback on trialn-1,compared to the betrayal feedback and the distrust choice,the frontocentral beta band oscillation had a stronger predictive effect regarding trust choices on trialn.These findings indicate that beta band oscillations during the decision generation stage contribute to subsequent trust choices.展开更多
文摘目的:通过观察运动疲劳后大鼠初级运动皮层M1-纹状体通路局部场电位(Local field potential,LFPs)相位同步振荡活动,结合DA信号系统在运动疲劳后代谢表达变化,探讨皮层-纹状体通路电信号编码在运动疲劳中枢调控中的机制及其与黑质-纹状体DA系统的协同作用。方法:采用Wistar大鼠建立运动疲劳模型,分为对照组(CG),7天力竭运动即刻组(7FG)以及7天重复力竭运动24 h恢复组(24RG)。采用在体多通道电生理同步记录技术,结合实时视频录像观察M1及纹状体LFPs电振荡活动,分析皮层M1-纹状体同步振荡的相干性;采用免疫组化检测纹状体背外侧区DA受体及相关转运体蛋白在运动疲劳前后的表达。结果:1)与CG组相比,7FG组皮层M1区及纹状体α及β振荡增强(P<0.05),恢复24 h后较7FG组PSD值显著下降(P<0.05),且皮层M1-纹状体α及β振荡相干系数变大、同步性增强(P<0.05);2)与7FG组相比,24RG组相干系数及STWA比率均显著下降(P<0.05);3)与CG组相比,7FG组纹状体背外侧区D2DR表达降低,VMAT2表达上调且差异具有显著性(P<0.05);4)与7FG组相比,24RG组背外侧纹状体区D1DR表达显著降低(P<0.05)。结论:运动疲劳后,D2DR减少可能是导致突触后致密物厚度变化的原因之一,造成纹状体GABA能活动增强,使纹状体电活动增强,反馈至皮层影响皮层综合信号的输出,进而影响大鼠行为活动能力。表明皮层M1和纹状体脑区之间同步振荡活动的改变可能是运动疲劳症状产生的原因之一,且D2DR作为黑质-纹状体DA信号系统的关键受体,可作为改善运动疲劳的干预靶点。
基金Project supported by the National Natural Science Foundation of China(Grant Nos.61473208 and 61876132)the Tianjin Research Program of Application Foundation and Advanced Technology,China(Grant No.15JCYBJC47700).
文摘Parkinson’s disease(PD)is characterized by pathological spontaneous beta oscillations(13 Hz-35 Hz)often observed in basal ganglia(BG)composed of subthalamic nucleus(STN)and globus pallidus(GPe)populations.From the viewpoint of dynamics,the spontaneous oscillations are related to limit cycle oscillations in a nonlinear system;here we employ the bifurcation analysis method to elucidate the generating mechanism of the pathological spontaneous beta oscillations underlined by coupling strengths and intrinsic properties of the STN-GPe circuit model.The results reveal that the increase of inter-coupling strength between STN and GPe populations induces the beta oscillations to be generated spontaneously,and causes the oscillation frequency to decrease.However,the increase of intra-coupling(self-feedback)strength of GPe can prevent the model from generating the oscillations,and dramatically increase the oscillation frequency.We further provide a theoretical explanation for the role played by the inter-coupling strength of GPe population in the generation and regulation of the oscillations.Furthermore,our study reveals that the intra-coupling strength of the GPe population provides a switching mechanism on the generation of the abnormal beta oscillations:for small value of the intra-coupling strength,STN population plays a dominant role in inducing the beta oscillations;while for its large value,the GPe population mainly determines the generation of this oscillation.
基金the National Natural Science Foundation of China(71942002 and 31771238)the National Social Science Foundation of China(19ZDA361)。
文摘Exploring neural markers that predict trust behavior may help us to identify the cognitive process underlying trust decisions and to develop a new approach to promote interpersonal trust.It remains unknown how trust behavior may be predicted early in the decision process.We used electrophysiology to sample the brain activity while participants played the role of trustor in an iterative trust game.The results showed that during the trust generation stage,the trust condition led to higher frontocentral beta band activity related to cognitive inhibition compared to the distrust condition(item level).Moreover,individuals with higher frontocentral beta band activity were more likely to perform trust choices at the single-trial level(individual level).Furthermore,after receiving reciprocity feedback on trialn-1,compared to the betrayal feedback and the distrust choice,the frontocentral beta band oscillation had a stronger predictive effect regarding trust choices on trialn.These findings indicate that beta band oscillations during the decision generation stage contribute to subsequent trust choices.
