Neurotrophic factors are best known for their roles in both development and continued maintenance of the nervous system.Their strong potential to elicit pro-survival and pro-functional responses in neurons of the peri...Neurotrophic factors are best known for their roles in both development and continued maintenance of the nervous system.Their strong potential to elicit pro-survival and pro-functional responses in neurons of the peripheral and central nervous system make them good drug candidates for treatment of a multitude of neurodegenerative disorders.However,significant obstacles remain and need to be overcome before translating the potential of neurotrophins into the therapeutic arena.This article addresses current efforts and advances in resolving these challenges and provides an overview of roadmaps for future translational research and neurotrophin-based drug developments.展开更多
基金This work was funded by NIH Neuroplasticity of Aging Predoctoral Training Grant to AW,UCSD NIH ADRC Pilot Grant,LLHF and DSRTF to CW.
文摘Neurotrophic factors are best known for their roles in both development and continued maintenance of the nervous system.Their strong potential to elicit pro-survival and pro-functional responses in neurons of the peripheral and central nervous system make them good drug candidates for treatment of a multitude of neurodegenerative disorders.However,significant obstacles remain and need to be overcome before translating the potential of neurotrophins into the therapeutic arena.This article addresses current efforts and advances in resolving these challenges and provides an overview of roadmaps for future translational research and neurotrophin-based drug developments.
