In this paper</span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;"> we present a thorough review of one of the most</span><span style...In this paper</span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;"> we present a thorough review of one of the most</span><span style="font-family:Verdana;"> life-threatening autoimmune diseases, Systemic lupus erythematosus (lupus). Symptoms, risk factors, including genetic and epidemiological factors are discussed. Treatment, life expectancies, and Health Related Quality of Life of patients with SLE will be discussed as well. Special attention will be given to Lupus Nephritis.展开更多
目的了解Graves病(GD)甲亢患者尤其合并有突眼、肝损害、WBC减少、低血钾的GD患者的外周血T淋巴细胞亚群状态,探讨GD及其合并症的免疫损伤机制。方法选取47例GD甲亢患者和46例健康对照者,测定其游离甲功、甲状腺特异性抗体、血常规、肝...目的了解Graves病(GD)甲亢患者尤其合并有突眼、肝损害、WBC减少、低血钾的GD患者的外周血T淋巴细胞亚群状态,探讨GD及其合并症的免疫损伤机制。方法选取47例GD甲亢患者和46例健康对照者,测定其游离甲功、甲状腺特异性抗体、血常规、肝功能、电解质及T淋巴细胞亚群(CD3+、CD4+、CD8),比较各组间相关指标的差异。结果 GD组CD4+/CD8+高于对照组(1.40±0.06 vs 1.32±0.07)(P<0.05)。GD甲亢WBC减少组CD3+低于WBC正常组(50.82±10.16 vs 58.42±10.48)(P<0.05)。GD甲亢低血钾组CD4+低于血钾正常组(44.70±8.34 vs 54.14±8.81)(P<0.05)。结论 GD患者体内存在细胞免疫的异常,合并有突眼、WBC减少、低血钾和(或)肝损害的GD患者,体内细胞和体液免疫损伤更加严重。GD甲亢是全身性自身免疫性疾病,早期激素的应用,可以避免严重的白细胞减少、严重肝损害和突眼。展开更多
BACKGROUND: Dubin-Johnson syndrome (DJS) is a rare clinical entity. We describe a case of DJS complicated by systemic lupus erythematosus (SLE). METHODS: A case of congenital hyperbilirubinemia with SLE was evaluated ...BACKGROUND: Dubin-Johnson syndrome (DJS) is a rare clinical entity. We describe a case of DJS complicated by systemic lupus erythematosus (SLE). METHODS: A case of congenital hyperbilirubinemia with SLE was evaluated systematically including review of history, physical examination for the stigmata of chronic liver disease, and other investigations. RESULT: Liver biopsy revealed a black liver with preserved architecture suggestive of DJS. CONCLUSIONS: SLE may develop in DJS. The relationship between DJS and SLE in this case is most likely a chance occurrence.展开更多
文摘In this paper</span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;"> we present a thorough review of one of the most</span><span style="font-family:Verdana;"> life-threatening autoimmune diseases, Systemic lupus erythematosus (lupus). Symptoms, risk factors, including genetic and epidemiological factors are discussed. Treatment, life expectancies, and Health Related Quality of Life of patients with SLE will be discussed as well. Special attention will be given to Lupus Nephritis.
文摘目的了解Graves病(GD)甲亢患者尤其合并有突眼、肝损害、WBC减少、低血钾的GD患者的外周血T淋巴细胞亚群状态,探讨GD及其合并症的免疫损伤机制。方法选取47例GD甲亢患者和46例健康对照者,测定其游离甲功、甲状腺特异性抗体、血常规、肝功能、电解质及T淋巴细胞亚群(CD3+、CD4+、CD8),比较各组间相关指标的差异。结果 GD组CD4+/CD8+高于对照组(1.40±0.06 vs 1.32±0.07)(P<0.05)。GD甲亢WBC减少组CD3+低于WBC正常组(50.82±10.16 vs 58.42±10.48)(P<0.05)。GD甲亢低血钾组CD4+低于血钾正常组(44.70±8.34 vs 54.14±8.81)(P<0.05)。结论 GD患者体内存在细胞免疫的异常,合并有突眼、WBC减少、低血钾和(或)肝损害的GD患者,体内细胞和体液免疫损伤更加严重。GD甲亢是全身性自身免疫性疾病,早期激素的应用,可以避免严重的白细胞减少、严重肝损害和突眼。
文摘BACKGROUND: Dubin-Johnson syndrome (DJS) is a rare clinical entity. We describe a case of DJS complicated by systemic lupus erythematosus (SLE). METHODS: A case of congenital hyperbilirubinemia with SLE was evaluated systematically including review of history, physical examination for the stigmata of chronic liver disease, and other investigations. RESULT: Liver biopsy revealed a black liver with preserved architecture suggestive of DJS. CONCLUSIONS: SLE may develop in DJS. The relationship between DJS and SLE in this case is most likely a chance occurrence.
