OBJECTIVE： This study assessed the efficacy and tolerability of repetitive transcranial magnetic stimulation for treatment of auditory hallucination of patients with schizophrenia spectrum disorders. DATA SOURCES： O...OBJECTIVE： This study assessed the efficacy and tolerability of repetitive transcranial magnetic stimulation for treatment of auditory hallucination of patients with schizophrenia spectrum disorders. DATA SOURCES： Online literature retrieval was conducted using PubMed, ISI Web of Science, EMBASE, Medline and Cochrane Central Register of Controlled Trials databases from January 1985 to May 2012. Key words were ＂transcranial magnetic stimulation＂, ＂TMS＂, ＂repetitive tran- scranial magnetic stimulation＂, and ＂hallucination＂. STUDY SELECTION： Selected studies were randomized controlled trials assessing therapeutic ef- ficacy of repetitive transcranial magnetic stimulation for hallucination in patients with schizophrenia spectrum disorders. Experimental intervention was low-frequency repetitive transcranial magnetic stimulation in left temporoparietal cortex for treatment of auditory hallucination in schizophrenia spectrum disorders. Control groups received sham stimulation. MAIN OUTCOME MEASURES： The primary outcome was total scores of Auditory Hallucinations Rating Scale, Auditory Hallucination Subscale of Psychotic Symptom Rating Scale, Positive and Negative Symptom Scale-Auditory Hallucination item, and Hallucination Change Scale. Secondary outcomes included response rate, global mental state, adverse effects and cognitive function. RESULTS： Seventeen studies addressing repetitive transcranial magnetic stimulation for treatment of schizophrenia spectrum disorders were screened, with controls receiving sham stimulation. All data were completely effective, involving 398 patients. Overall mean weighted effect size for repeti- tive transcranial magnetic stimulation versus sham stimulation was statistically significant （MD = -0.42, 95%C/： -0.64 to -0.20, P = 0.000 2）. Patients receiving repetitive transcranial magnetic stimulation responded more frequently than sham stimulation （OR = 2.94, 95%C/： 1.39 to 6.24, P =0.005）. No significant differences were found between active repetiti展开更多
目的探讨电针听宫穴和翳风穴对豚鼠听皮层葡萄糖代谢和胰岛素样生长因子-1(insulin like growth factor-1,IGF-1)表达的影响。方法将成年杂色豚鼠18只随机分为3组,电针耳穴组7只,同时电针双侧听宫和翳风穴,持续15分钟,每日1次,共7天;电...目的探讨电针听宫穴和翳风穴对豚鼠听皮层葡萄糖代谢和胰岛素样生长因子-1(insulin like growth factor-1,IGF-1)表达的影响。方法将成年杂色豚鼠18只随机分为3组,电针耳穴组7只,同时电针双侧听宫和翳风穴,持续15分钟,每日1次,共7天;电针非穴位组6只,电针听宫穴靠眼侧方5mm处和翳风穴正下方5mm处,时间同电针耳穴组;对照组5只不作任何处理,常规饲养。各组完成电针后进行PET/CT扫描,获得CT、PET及两者融合图像,观察豚鼠听皮层摄取显像剂18F-脱氧葡萄糖的情况,以听皮层和小脑最大标准摄入值(standard uptake value,SUV)的比值为观察指标;采用实时荧光定量PCR技术检测豚鼠听皮层IGF-1mRNA表达。结果对照组、电针耳穴组、电针非耳穴组听皮层SUV最大值与小脑SUV最大值的比值分别为0.75±0.06、0.84±0.05和0.71±0.06,电针耳穴组高于对照组和电针非耳穴组,(分别为P=0.042,P=0.009);对照组、电针耳穴组、电针非耳穴组听皮层局部IGF-1mRNA相对表达量分别为1.34±0.24、2.03±0.36、0.92±0.23,电针耳穴组高于对照组和电针非耳穴组(分别为P=0.002,P<0.001)。结论电针针刺听宫和翳风穴可增加豚鼠听皮层局部IGF-1的表达,可能通过提高葡萄糖代谢水平促进豚鼠听皮层的功能。展开更多
基金financially sponsored by the Special Funding of Henan Health Science and Technology Innovation Talent Project,No.4173(2010-2015)Xinxiang Medical University of High-Level Personnel of Scientific Research Projects,No.08BSKYQD-004the Key Projects of Science and Technology Research of Department of Education in Henan,No.13A320869
文摘OBJECTIVE： This study assessed the efficacy and tolerability of repetitive transcranial magnetic stimulation for treatment of auditory hallucination of patients with schizophrenia spectrum disorders. DATA SOURCES： Online literature retrieval was conducted using PubMed, ISI Web of Science, EMBASE, Medline and Cochrane Central Register of Controlled Trials databases from January 1985 to May 2012. Key words were ＂transcranial magnetic stimulation＂, ＂TMS＂, ＂repetitive tran- scranial magnetic stimulation＂, and ＂hallucination＂. STUDY SELECTION： Selected studies were randomized controlled trials assessing therapeutic ef- ficacy of repetitive transcranial magnetic stimulation for hallucination in patients with schizophrenia spectrum disorders. Experimental intervention was low-frequency repetitive transcranial magnetic stimulation in left temporoparietal cortex for treatment of auditory hallucination in schizophrenia spectrum disorders. Control groups received sham stimulation. MAIN OUTCOME MEASURES： The primary outcome was total scores of Auditory Hallucinations Rating Scale, Auditory Hallucination Subscale of Psychotic Symptom Rating Scale, Positive and Negative Symptom Scale-Auditory Hallucination item, and Hallucination Change Scale. Secondary outcomes included response rate, global mental state, adverse effects and cognitive function. RESULTS： Seventeen studies addressing repetitive transcranial magnetic stimulation for treatment of schizophrenia spectrum disorders were screened, with controls receiving sham stimulation. All data were completely effective, involving 398 patients. Overall mean weighted effect size for repeti- tive transcranial magnetic stimulation versus sham stimulation was statistically significant （MD = -0.42, 95%C/： -0.64 to -0.20, P = 0.000 2）. Patients receiving repetitive transcranial magnetic stimulation responded more frequently than sham stimulation （OR = 2.94, 95%C/： 1.39 to 6.24, P =0.005）. No significant differences were found between active repetiti
