Cynanchum is one of the most important genera in Asclepiadaceae family, which has long been known for its therapeutic effects. In this genus, 16 species are of high medicinal value. The extracts of the root and/or rhi...Cynanchum is one of the most important genera in Asclepiadaceae family, which has long been known for its therapeutic effects. In this genus, 16 species are of high medicinal value. The extracts of the root and/or rhizome parts have been applied in traditional Chinese medicines(TCM) for the prevention and treatment of various illnesses for centuries. C21 steroids, as the typical constituents of Cynanchum species, possess a variety of structures and pharmacological activities. This review summarizes the comprehensive information on phytochemistry and pharmacology of C21 steroid constituents from Cynanchum plants, based on reports published between 2007 and 2015. Our aim is to provide a rationale for their therapeutic application, and to discuss the future trends in research and development of these compounds. A total of 172 newly identified compounds are reviewed according to their structural classifications. Their in vitro and in vivo pharmacological studies are also reviewed and discussed, focusing on antitumor, antidepressant, antifungal, antitaging, Na+/K+-ATPase inhibitory, appetite suppressing and antiviral activities. Future research efforts should concentrate on in vitro and in vivo biological studies and structure activity relationship of various C21 steroid constituents.展开更多
Three new C21 steroidal glycosides named komaroside A, komaroside B, komaroside C were isolated from the ethanolic extract of the roots of Cynanchum komarovii Al.Iljinski (Asclepiadaceae), their structures were determ...Three new C21 steroidal glycosides named komaroside A, komaroside B, komaroside C were isolated from the ethanolic extract of the roots of Cynanchum komarovii Al.Iljinski (Asclepiadaceae), their structures were determined by physiochemical and spectroscopic analysis.展开更多
Three new C21 steroidal glycosides named inamoside E （1）, inamoside F （2） and inamoside G （3） were isolated from the roots of Cynanchum inamoenum （Maxim.） Loes. Their structures were determined by spectroscopi...Three new C21 steroidal glycosides named inamoside E （1）, inamoside F （2） and inamoside G （3） were isolated from the roots of Cynanchum inamoenum （Maxim.） Loes. Their structures were determined by spectroscopic analysis, especially by ID and 2D NMR experiments.展开更多
基金financially supported by the National Natural Science Foundation of China(No.21502014)
文摘Cynanchum is one of the most important genera in Asclepiadaceae family, which has long been known for its therapeutic effects. In this genus, 16 species are of high medicinal value. The extracts of the root and/or rhizome parts have been applied in traditional Chinese medicines(TCM) for the prevention and treatment of various illnesses for centuries. C21 steroids, as the typical constituents of Cynanchum species, possess a variety of structures and pharmacological activities. This review summarizes the comprehensive information on phytochemistry and pharmacology of C21 steroid constituents from Cynanchum plants, based on reports published between 2007 and 2015. Our aim is to provide a rationale for their therapeutic application, and to discuss the future trends in research and development of these compounds. A total of 172 newly identified compounds are reviewed according to their structural classifications. Their in vitro and in vivo pharmacological studies are also reviewed and discussed, focusing on antitumor, antidepressant, antifungal, antitaging, Na+/K+-ATPase inhibitory, appetite suppressing and antiviral activities. Future research efforts should concentrate on in vitro and in vivo biological studies and structure activity relationship of various C21 steroid constituents.
文摘Three new C21 steroidal glycosides named komaroside A, komaroside B, komaroside C were isolated from the ethanolic extract of the roots of Cynanchum komarovii Al.Iljinski (Asclepiadaceae), their structures were determined by physiochemical and spectroscopic analysis.
文摘Three new C21 steroidal glycosides named inamoside E （1）, inamoside F （2） and inamoside G （3） were isolated from the roots of Cynanchum inamoenum （Maxim.） Loes. Their structures were determined by spectroscopic analysis, especially by ID and 2D NMR experiments.
文摘从萝蘼科植物大叶牛奶菜(Marsdenia koi Tsiang)的具有抗生育活性的甲醇提取物中,用硅胶层析及反相层析等方法分得一种孕甾甙,经波谱(IR,~1H-NMR,^(13)C-NMR,FAB-MS)分析及其水解产物与标准品对照,确定为一新孕甾甙,命名为大叶牛奶菜甙丙(marsdekoiside C)
