The development of antimicrobial resistance (AMR) due to over or misuse of antibiotics/antimicrobials is a globally increasing public health concern. This study was conducted to assess the current knowledge, attitudes...The development of antimicrobial resistance (AMR) due to over or misuse of antibiotics/antimicrobials is a globally increasing public health concern. This study was conducted to assess the current knowledge, attitudes, and practices (KAP) of swine and poultry producers on antimicrobial use (AMU) and antimicrobial resistance (AMR). A total of 254 swine and poultry producers of 5 provinces in Cambodia were purposively surveyed using validated KAP questionnaires, a useful tool for promoting the rational use of antimicrobials in livestock. Collectively, this study found out that livestock producers in Cambodia have a low level of knowledge, neutral rather than positive attitudes, and employed poor practices on the AMU and AMR. Thus, there is a need to promote among producers the rational and responsible use of antimicrobials. Furthermore, public awareness of the AMR implications on public health can contribute to the prevention or reduction of AMU and AMR in Cambodia.展开更多
Antimicrobials are critical to contemporary high-intensity beef production. Many different antimicrobials are approved for beef cattle, and are used judiciously for animal welfare, and controversially, to promote grow...Antimicrobials are critical to contemporary high-intensity beef production. Many different antimicrobials are approved for beef cattle, and are used judiciously for animal welfare, and controversially, to promote growth and feed efficiency. Antimicrobial administration provides a powerful selective pressure that acts on the microbial community, selecting for resistance gene determinants and antimicrobial-resistant bacteria resident in the bovine flora. The bovine microbiota includes many harmless bacteria, but also opportunistic pathogens that may acquire and propagate resistance genes within the microbial community via horizontal gene transfer. Antimicrobial-resistant bovine pathogens can also complicate the prevention and treatment of infectious diseases in beef feedlots,threatening the efficiency of the beef production system. Likewise, the transmission of antimicrobial resistance genes to bovine-associated human pathogens is a potential public health concern. This review outlines current antimicrobial use practices pertaining to beef production, and explores the frequency of antimicrobial resistance in major bovine pathogens. The effect of antimicrobials on the composition of the bovine microbiota is examined, as are the effects on the beef production resistome. Antimicrobial resistance is further explored within the context of the wider beef production continuum, with emphasis on antimicrobial resistance genes in the food chain, and risk to the human population.展开更多
文摘The development of antimicrobial resistance (AMR) due to over or misuse of antibiotics/antimicrobials is a globally increasing public health concern. This study was conducted to assess the current knowledge, attitudes, and practices (KAP) of swine and poultry producers on antimicrobial use (AMU) and antimicrobial resistance (AMR). A total of 254 swine and poultry producers of 5 provinces in Cambodia were purposively surveyed using validated KAP questionnaires, a useful tool for promoting the rational use of antimicrobials in livestock. Collectively, this study found out that livestock producers in Cambodia have a low level of knowledge, neutral rather than positive attitudes, and employed poor practices on the AMU and AMR. Thus, there is a need to promote among producers the rational and responsible use of antimicrobials. Furthermore, public awareness of the AMR implications on public health can contribute to the prevention or reduction of AMU and AMR in Cambodia.
基金supported by an NSERC Postdoctoral Fellowshipsupported by the Beef Cattle Research Council BCRC–Agriculture and Agri-Food Canada beef cluster
文摘Antimicrobials are critical to contemporary high-intensity beef production. Many different antimicrobials are approved for beef cattle, and are used judiciously for animal welfare, and controversially, to promote growth and feed efficiency. Antimicrobial administration provides a powerful selective pressure that acts on the microbial community, selecting for resistance gene determinants and antimicrobial-resistant bacteria resident in the bovine flora. The bovine microbiota includes many harmless bacteria, but also opportunistic pathogens that may acquire and propagate resistance genes within the microbial community via horizontal gene transfer. Antimicrobial-resistant bovine pathogens can also complicate the prevention and treatment of infectious diseases in beef feedlots,threatening the efficiency of the beef production system. Likewise, the transmission of antimicrobial resistance genes to bovine-associated human pathogens is a potential public health concern. This review outlines current antimicrobial use practices pertaining to beef production, and explores the frequency of antimicrobial resistance in major bovine pathogens. The effect of antimicrobials on the composition of the bovine microbiota is examined, as are the effects on the beef production resistome. Antimicrobial resistance is further explored within the context of the wider beef production continuum, with emphasis on antimicrobial resistance genes in the food chain, and risk to the human population.
