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中药抗菌成分及其抗菌机制的研究进展 被引量:68
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作者 刘云宁 李小凤 +1 位作者 班旭霞 姜爱雯 《环球中医药》 CAS 2015年第8期1012-1017,共6页
抗生素的抗菌作用显著,但其毒副作用、所引起的二重感染及细菌的耐药等问题,使其应用受到一定限制。从单味中药及单体化合物、中药复方制剂的抑菌实验3方面的研究已证实多种中药均具有抗菌作用,且具有不易产生耐药的特点与优势。研究还... 抗生素的抗菌作用显著,但其毒副作用、所引起的二重感染及细菌的耐药等问题,使其应用受到一定限制。从单味中药及单体化合物、中药复方制剂的抑菌实验3方面的研究已证实多种中药均具有抗菌作用,且具有不易产生耐药的特点与优势。研究还发现,中药的抗细菌作用机制不同于抗生素,其作用机理较为复杂,表现为对细菌的直接抑杀、抑制酶的活性、逆转耐药机制和调节机体免疫功能等多种作用综合的结果。本文就近年来中药制剂的抗菌作用、抗菌活性成分及其抗菌机制进行综述。 展开更多
关键词 中药 抗菌作用 抗菌活性成分 抗菌机制
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川椒丸对小鼠体内抑菌作用的实验研究 被引量:3
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作者 邹瑾 唐逸红 +1 位作者 刘巧灵 尹进 《中医临床研究》 2010年第23期47-48,50,共3页
目的:观察川椒丸对小鼠体内肠道常见致病菌的影响,探讨其治疗湿热泄泻的作用机制。方法:分别腹腔注射小鼠致死量大肠杆菌、乙型副伤寒杆菌、痢疾杆菌3种不同的细菌菌悬液,制作腹泻感染动物模型,观察川椒丸高、中、低3个不同剂量(... 目的:观察川椒丸对小鼠体内肠道常见致病菌的影响,探讨其治疗湿热泄泻的作用机制。方法:分别腹腔注射小鼠致死量大肠杆菌、乙型副伤寒杆菌、痢疾杆菌3种不同的细菌菌悬液,制作腹泻感染动物模型,观察川椒丸高、中、低3个不同剂量(以下简称九香高、中、低剂量组)及肠康片、诺氟沙星胶袭对感染小鼠模型的存活率、存活动时间的影响。结果:与模型相比,各药物组均可显著提高3种不同细菌感染小鼠模型的存活率、明显延长其存活时间,差异具有统计学意义(P〈0.05),其中,诺氟沙星组、九香高制剂量组均明显优于肠康片组,差异具有统计学意义(P〈0.05),而九香中剂量组与肠康片组、九香高制剂量组与诺言氟沙星对感染模型小鼠存活率的提高及存活时间的延长相当。结论:川椒丸对腹腔注射致死量大肠杆菌、痢疾杆菌和乙型副伤寒杆菌等感染小鼠模型可明显提高其存活率,显著延长感染小鼠存活时间,并呈现一定的量效关系,表明其对感染模型小鼠具有较好的保护作用,对体内肠道常见致病菌具有较好抑制作用。 展开更多
关键词 川椒丸 保护作用 乌梅 小鼠 泄泻 抑菌作用
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The Ionic Composition of Nasal Fluid and Its Function 被引量:1
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作者 William Burke 《Health》 2014年第8期720-728,共9页
The aim of the experiments reported here is to increase our understanding of the function of the nasal fluid. It is generally accepted that the nasal fluid assists in the humidification of the inspired air. It also as... The aim of the experiments reported here is to increase our understanding of the function of the nasal fluid. It is generally accepted that the nasal fluid assists in the humidification of the inspired air. It also assists in the capture of inspired particles such as pollen, preventing them getting lodged in the lungs. It is also known to contain antibacterial substances which keep the nose, nasopharynx and respiratory passages relatively free of infection. There are other features of the nasal fluid that are not understood. In cold weather, is it the fluid that collects in the nostrils pure water or nasal fluid? Why does nasal fluid have an exceptionally high potassium concentration? Does nasal fluid secreted during the common cold have the same composition as at other times? My objectives are to try to answer these questions. My method is to collect my nasal fluid in several different ways and have the ionic composition of each determined accurately. My findings are that nasal fluid is similar in composition however it is secreted. In cold weather, if expiration is via the nose, the nasal fluid is diluted by condensed water. The high concentration of potassium in the nasal fluid is not a way of controlling the level of potassium in the body but I suggest that it may assist in maintaining the antibacterial property of the nasal fluid. 展开更多
关键词 NASAL SECRETION High POTASSIUM Content SECRETION in COLD Environment antibacterial role
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