Objective:To explore the mechanism of anti-rheumatic effect of the active fraction of Siegesbeckia pubescens(AFSP).Methods:Adjuvant arthritis(AA)model of rat was produced to observe the effect of AFSP on lymphocyte pr...Objective:To explore the mechanism of anti-rheumatic effect of the active fraction of Siegesbeckia pubescens(AFSP).Methods:Adjuvant arthritis(AA)model of rat was produced to observe the effect of AFSP on lymphocyte proliferation,interleukin-1 and-2(IL-1,-2)activity,pathologic section of ankle joint,and analgesic effect,in model rat.Results:AFSP could reduce the inflammatory pathologic response of ankle joint.It has good analgesic effect,the analgesic rate being 65%.AFSP could also strengthen T-lymphocyte proliferation,promote IL-2 activity and inhibit IL-1 activity.Compared with the control group,the difference was significant(P<0.01).Conclusion:By means of regulating the immune function of organism,AFSP could improve the local pathologic response to antagonize against rheumatism,therefore,it is an effective anti-rheumatism herbal medicine.展开更多
文摘Objective:To explore the mechanism of anti-rheumatic effect of the active fraction of Siegesbeckia pubescens(AFSP).Methods:Adjuvant arthritis(AA)model of rat was produced to observe the effect of AFSP on lymphocyte proliferation,interleukin-1 and-2(IL-1,-2)activity,pathologic section of ankle joint,and analgesic effect,in model rat.Results:AFSP could reduce the inflammatory pathologic response of ankle joint.It has good analgesic effect,the analgesic rate being 65%.AFSP could also strengthen T-lymphocyte proliferation,promote IL-2 activity and inhibit IL-1 activity.Compared with the control group,the difference was significant(P<0.01).Conclusion:By means of regulating the immune function of organism,AFSP could improve the local pathologic response to antagonize against rheumatism,therefore,it is an effective anti-rheumatism herbal medicine.
