Two new complexes （Cp）2Ti （Sal）2 and（Cp）2Ti（Clo）2 （Cp=Cyclopentadienyl η^5-C5H5 ）, have been synthesized in anhydrous THF by the reaction of HSal（o-hydroxybenzoic acid, salicylate acid） or HClo[N-（ m-chl...Two new complexes （Cp）2Ti （Sal）2 and（Cp）2Ti（Clo）2 （Cp=Cyclopentadienyl η^5-C5H5 ）, have been synthesized in anhydrous THF by the reaction of HSal（o-hydroxybenzoic acid, salicylate acid） or HClo[N-（ m-chloro-phenyl） anthranili acid, acidum clofenamicum] with （Cp）2TiCl2 and characterized by means of elemental analyses, IR, H NMR, ^13C NMR, UV and molar conductivity. In complex （Cp）2Ti（Sal）2 or（Cp）2Ti（Clo）2, the oxygen atom of the carboxyl group coordinates to Ti（Ⅳ） in a monodentate manner. The inhibitory action of the complexes on mouse ear tumefaction caused by croton oil and rat foot granulation growth caused by cotton balls is higher than that of the corresponding ligands HSal, HClo and [ （Cp）2TiCl2 ], whereas their toxicity is lower than those of the free ligands.展开更多
Six isochromano [4, 3-c]pyrazole derivatives were synthesized from isochroman-4-one as starting compound. Some of the products show a significant anti-inflammatory activi-ty.
Objective: To evaluate the scientific basis for the use of Kang 601 heji(K-601) as an anti-in flammatory and antipyretic agent using appropriate animal models.Methods: Carrageenan-induced rat paw and xylene-induced ea...Objective: To evaluate the scientific basis for the use of Kang 601 heji(K-601) as an anti-in flammatory and antipyretic agent using appropriate animal models.Methods: Carrageenan-induced rat paw and xylene-induced ear oedemas were models used to investigate anti-in flammatory actions of K-601. Lipopolysaccharide-induced pyrexia model was used to evaluate antipyretic activity in Wistar rats. The antiin flammatory and antipyretic mechanisms were evaluated by detecting prostaglandins E2, nitric oxide, interleukin-1b and tumour necrosis factora levels using appropriate reagents and ELISA kits.Results: The results revealed that K-601 reduced the level of in flammations in both antiin flammatory models in a dose-dependent manner. The same was true for the antipyretic model. The possible mechanisms of actions were through the inhibition of prostaglandins E2, interleukin-1b, tumour necrosis factora and nitric oxide.Conclusions: K-601 has proven anti-in flammatory and antipyretic actions. The findings provide a scientific basis for the use of K-601 as anti-in flammatory and antipyretic agent in traditional Chinese medicinal practice.展开更多
文摘Two new complexes （Cp）2Ti （Sal）2 and（Cp）2Ti（Clo）2 （Cp=Cyclopentadienyl η^5-C5H5 ）, have been synthesized in anhydrous THF by the reaction of HSal（o-hydroxybenzoic acid, salicylate acid） or HClo[N-（ m-chloro-phenyl） anthranili acid, acidum clofenamicum] with （Cp）2TiCl2 and characterized by means of elemental analyses, IR, H NMR, ^13C NMR, UV and molar conductivity. In complex （Cp）2Ti（Sal）2 or（Cp）2Ti（Clo）2, the oxygen atom of the carboxyl group coordinates to Ti（Ⅳ） in a monodentate manner. The inhibitory action of the complexes on mouse ear tumefaction caused by croton oil and rat foot granulation growth caused by cotton balls is higher than that of the corresponding ligands HSal, HClo and [ （Cp）2TiCl2 ], whereas their toxicity is lower than those of the free ligands.
文摘Six isochromano [4, 3-c]pyrazole derivatives were synthesized from isochroman-4-one as starting compound. Some of the products show a significant anti-inflammatory activi-ty.
基金Supported in part by the National Natural Science Foundation of China(Nos.81222052 and 81421005)Jiangsu Province Science Fund for Distinguished Young Scholars(BK20130025)
文摘Objective: To evaluate the scientific basis for the use of Kang 601 heji(K-601) as an anti-in flammatory and antipyretic agent using appropriate animal models.Methods: Carrageenan-induced rat paw and xylene-induced ear oedemas were models used to investigate anti-in flammatory actions of K-601. Lipopolysaccharide-induced pyrexia model was used to evaluate antipyretic activity in Wistar rats. The antiin flammatory and antipyretic mechanisms were evaluated by detecting prostaglandins E2, nitric oxide, interleukin-1b and tumour necrosis factora levels using appropriate reagents and ELISA kits.Results: The results revealed that K-601 reduced the level of in flammations in both antiin flammatory models in a dose-dependent manner. The same was true for the antipyretic model. The possible mechanisms of actions were through the inhibition of prostaglandins E2, interleukin-1b, tumour necrosis factora and nitric oxide.Conclusions: K-601 has proven anti-in flammatory and antipyretic actions. The findings provide a scientific basis for the use of K-601 as anti-in flammatory and antipyretic agent in traditional Chinese medicinal practice.
