目的探讨伴有暴力倾向的精神分裂症患者静息状态下脑自发神经活动特征以及其脑功能异常的神经病理生理机制。方法纳入符合ICD-10诊断标准的精神分裂症患者35例(男24例、女11例)。采用PANSS评分评估患者临床症状严重程度。利用修订版外...目的探讨伴有暴力倾向的精神分裂症患者静息状态下脑自发神经活动特征以及其脑功能异常的神经病理生理机制。方法纳入符合ICD-10诊断标准的精神分裂症患者35例(男24例、女11例)。采用PANSS评分评估患者临床症状严重程度。利用修订版外显攻击行为量表(Modified Overt Aggression Scale,MOAS)评分将患者分为暴力组和无暴力组。应用静息态功能磁共振成像(resting state functional magnetic resonance imaging,rs-fMRI)技术,采集所有患者静息状态下脑fMRI数据,基于DPABI V2.3(Data Processing&Analysis of Brain Imaging,DPABI)软件,对数据进行预处理后得到低频振幅(amplitude of low-frequency fluctuation,ALFF)及分数低频振幅(fractional amplitude of low-frequency fluctuation,fALFF)图,采用双样本t检验比较2组图像差异。提取所有患者全脑区的ALFF、fALFF值与PANSS评分进行Pearson相关分析。结果暴力组(n=18)较无暴力组(n=17)右侧顶上回、右侧顶下缘角回ALFF值减低,而右侧小脑下部、左侧小脑下部和左侧丘脑的fALFF值增高(均经GRF校正,体素水平P<0.01,簇水平P<0.05)。Pearson相关分析显示,精神分裂症患者(n=35)右侧小脑下部、小脑蚓部、右侧颞中回ALFF值与PANSS阴性症状评分呈正相关(r=0.437、0.610、0.656);右侧角回fALFF值与PANSS阴性症状评分呈负相关(r=-0.723);左侧内侧额上回fALFF值与PANSS敌对性评分呈正相关(r=0.647,均经GRF校正,体素水平P<0.01,簇水平P<0.05)。结论相较于无暴力患者,伴有暴力倾向的精神分裂症患者多个脑区ALFF、fALFF值存在差异,提示伴有暴力行为的患者多个脑区自发神经活动异常。展开更多
Acupuncture can induce changes in the brain. However, the majority of studies to date have focused on a single acupoint at a time. In the present study, we observed activity changes in the brains of healthy volunteers...Acupuncture can induce changes in the brain. However, the majority of studies to date have focused on a single acupoint at a time. In the present study, we observed activity changes in the brains of healthy volunteers before and after acupuncture atTaichong （LR3） andTaixi （KI3） using resting-state functional magnetic resonance imaging. Fifteen healthy volunteers underwent resting-state functional magnetic resonance imaging of the brain 15 minutes before acupuncture, then received acupuncture atTaichong andTaixi using the nail-pressing needle insertion method, after which the needle was retained in place for 30 minutes. Fifteen minutes after withdrawal of the needle, the volunteers underwent a further session of resting-state functional magnetic res-onance imaging, which revealed that the amplitude of low-frequency lfuctuation, a measure of spontaneous neuronal activity, increased mainly in the cerebral occipital lobe and middle occipital gyrus （Brodmann area 18/19）, inferior occipital gyrus （Brodmann area 18） and cuneus （Brodmann area 18）, but decreased mainly in the gyrus rectus of the frontal lobe （Brodmann area 11）, inferi-or frontal gyrus （Brodmann area 44） and the center of the posterior lobe of the cerebellum. The present ifndings indicate that acupuncture atTaichong andTaixi speciifcally promote blood lfow and activation in the brain areas related to vision, emotion and cognition, and inhibit brain areas related to emotion, attention, phonological and semantic processing, and memory.展开更多
目的探讨男性酒依赖患者戒断期静息态下脑区神经元自发活动改变及其与认知功能关系。方法对23例男性酒依赖患者和20名健康成年男性进行脑静息态功能磁共振扫描,比较其全脑各脑区低频振幅(amplitude of low-frequency fluctuation,ALFF)...目的探讨男性酒依赖患者戒断期静息态下脑区神经元自发活动改变及其与认知功能关系。方法对23例男性酒依赖患者和20名健康成年男性进行脑静息态功能磁共振扫描,比较其全脑各脑区低频振幅(amplitude of low-frequency fluctuation,ALFF),并用简易精神状态量表(mini mental status scale,MMSE)、语言流畅性测验(verbal fluency test,VFT)、数字广度测验(digit span test,DST)、霍普金斯词语学习修订版(Hopkins verbal learning test revised,HVLT-R)及连线测试B(trail making test-B,TMT-B)分别评估两组认知功能。结果酒依赖组与对照组相比ALFF减弱脑区为左侧额上回(t=-4.49,P<0.01)、右侧额中回(t=-3.55,P<0.01)、右侧颞上回(t=-5.36,P<0.01)、左侧前扣带回(t=-5.41,P<0.01);ALFF增强的脑区有左侧枕叶(t=3.90,P<0.01)、左侧小脑后叶(t=3.58,P<0.01)。神经心理测评中,酒依赖组MMSE(t=-4.33,P<0.01)、VFT(t=-2.86,P<0.01)、DST(t=-4.93,P<0.01)和HVLT-R(t=-5.16,P<0.01)评分均低于对照组;TMT-B完成时间高于对照组(t=4.67,P<0.01)。酒依赖患者右侧额中回ALFF值与VFT评分呈正相关(r=0.49,P=0.04)。结论男性酒依赖患者戒断期在静息态下存在双侧额叶、右侧颞叶、左侧前扣带回、左侧枕叶、左侧小脑脑区功能活动异常,且右侧额叶脑区功能活动改变与语言功能异常有相关性。展开更多
文摘目的探讨伴有暴力倾向的精神分裂症患者静息状态下脑自发神经活动特征以及其脑功能异常的神经病理生理机制。方法纳入符合ICD-10诊断标准的精神分裂症患者35例(男24例、女11例)。采用PANSS评分评估患者临床症状严重程度。利用修订版外显攻击行为量表(Modified Overt Aggression Scale,MOAS)评分将患者分为暴力组和无暴力组。应用静息态功能磁共振成像(resting state functional magnetic resonance imaging,rs-fMRI)技术,采集所有患者静息状态下脑fMRI数据,基于DPABI V2.3(Data Processing&Analysis of Brain Imaging,DPABI)软件,对数据进行预处理后得到低频振幅(amplitude of low-frequency fluctuation,ALFF)及分数低频振幅(fractional amplitude of low-frequency fluctuation,fALFF)图,采用双样本t检验比较2组图像差异。提取所有患者全脑区的ALFF、fALFF值与PANSS评分进行Pearson相关分析。结果暴力组(n=18)较无暴力组(n=17)右侧顶上回、右侧顶下缘角回ALFF值减低,而右侧小脑下部、左侧小脑下部和左侧丘脑的fALFF值增高(均经GRF校正,体素水平P<0.01,簇水平P<0.05)。Pearson相关分析显示,精神分裂症患者(n=35)右侧小脑下部、小脑蚓部、右侧颞中回ALFF值与PANSS阴性症状评分呈正相关(r=0.437、0.610、0.656);右侧角回fALFF值与PANSS阴性症状评分呈负相关(r=-0.723);左侧内侧额上回fALFF值与PANSS敌对性评分呈正相关(r=0.647,均经GRF校正,体素水平P<0.01,簇水平P<0.05)。结论相较于无暴力患者,伴有暴力倾向的精神分裂症患者多个脑区ALFF、fALFF值存在差异,提示伴有暴力行为的患者多个脑区自发神经活动异常。
基金supported by a grant from the National Key Basic Research and Development Project(973 Program),No.2012CB518504a grant from the National Level Undergraduate Student Innovation Venture Training Project of Local Colleges,No.201212121048a grant from the ThreeStage Key Subject Construction Project of Guangdong Province of China(211 Project),No.(2009)431
文摘Acupuncture can induce changes in the brain. However, the majority of studies to date have focused on a single acupoint at a time. In the present study, we observed activity changes in the brains of healthy volunteers before and after acupuncture atTaichong （LR3） andTaixi （KI3） using resting-state functional magnetic resonance imaging. Fifteen healthy volunteers underwent resting-state functional magnetic resonance imaging of the brain 15 minutes before acupuncture, then received acupuncture atTaichong andTaixi using the nail-pressing needle insertion method, after which the needle was retained in place for 30 minutes. Fifteen minutes after withdrawal of the needle, the volunteers underwent a further session of resting-state functional magnetic res-onance imaging, which revealed that the amplitude of low-frequency lfuctuation, a measure of spontaneous neuronal activity, increased mainly in the cerebral occipital lobe and middle occipital gyrus （Brodmann area 18/19）, inferior occipital gyrus （Brodmann area 18） and cuneus （Brodmann area 18）, but decreased mainly in the gyrus rectus of the frontal lobe （Brodmann area 11）, inferi-or frontal gyrus （Brodmann area 44） and the center of the posterior lobe of the cerebellum. The present ifndings indicate that acupuncture atTaichong andTaixi speciifcally promote blood lfow and activation in the brain areas related to vision, emotion and cognition, and inhibit brain areas related to emotion, attention, phonological and semantic processing, and memory.
文摘目的探讨男性酒依赖患者戒断期静息态下脑区神经元自发活动改变及其与认知功能关系。方法对23例男性酒依赖患者和20名健康成年男性进行脑静息态功能磁共振扫描,比较其全脑各脑区低频振幅(amplitude of low-frequency fluctuation,ALFF),并用简易精神状态量表(mini mental status scale,MMSE)、语言流畅性测验(verbal fluency test,VFT)、数字广度测验(digit span test,DST)、霍普金斯词语学习修订版(Hopkins verbal learning test revised,HVLT-R)及连线测试B(trail making test-B,TMT-B)分别评估两组认知功能。结果酒依赖组与对照组相比ALFF减弱脑区为左侧额上回(t=-4.49,P<0.01)、右侧额中回(t=-3.55,P<0.01)、右侧颞上回(t=-5.36,P<0.01)、左侧前扣带回(t=-5.41,P<0.01);ALFF增强的脑区有左侧枕叶(t=3.90,P<0.01)、左侧小脑后叶(t=3.58,P<0.01)。神经心理测评中,酒依赖组MMSE(t=-4.33,P<0.01)、VFT(t=-2.86,P<0.01)、DST(t=-4.93,P<0.01)和HVLT-R(t=-5.16,P<0.01)评分均低于对照组;TMT-B完成时间高于对照组(t=4.67,P<0.01)。酒依赖患者右侧额中回ALFF值与VFT评分呈正相关(r=0.49,P=0.04)。结论男性酒依赖患者戒断期在静息态下存在双侧额叶、右侧颞叶、左侧前扣带回、左侧枕叶、左侧小脑脑区功能活动异常,且右侧额叶脑区功能活动改变与语言功能异常有相关性。
