目的探讨非酒精性脂肪肝(NAFLD)患者体内循环脂肪素(adipsin)、内脂素(visfatin)和鸢尾素(irisin)水平及其相关性。方法选取我院2018年1月至2019年12月门诊及住院的NAFLD患者120例和性别、年龄等一般情况相匹配的正常人120例,采集两组...目的探讨非酒精性脂肪肝(NAFLD)患者体内循环脂肪素(adipsin)、内脂素(visfatin)和鸢尾素(irisin)水平及其相关性。方法选取我院2018年1月至2019年12月门诊及住院的NAFLD患者120例和性别、年龄等一般情况相匹配的正常人120例,采集两组受试者血样,记录并分析其一般生化指标、血清adipsin、visfatin和irisin的浓度水平。测量并计算体质量指数(body mass index,BMI)和胰岛素抵抗指数(insulin resistance of homeostasis model assessment,HOMA-IR)。分析血清adipsin、visfatin和irisin水平与NAFLD发病的相关性。结果NAFLD患者BMI、TG、TC、AST、ALT、FBG、HOMR-IR、adipsin水平较对照组高,HDL-C、visfatin和irisin水平较对照组低(P<0.05)。NAFLD患者adipsin水平与BMI、FBG、FINS、HOMA-IR、TG呈正相关(P<0.05);NAFLD患者visfatin及irisin水平均与BMI、FBG、FINS、HOMA-IR、TG呈负相关(P<0.05)。按四分位法、最高四分位数组与最低四分位数组比较,adipsin、visfatin、adipsin与NAFLD患病风险的OR值分别为4.15(95%CI:1.18~14.66)、0.15(95%CI:0.05~0.53)和0.20(95%CI:0.06~0.71)。结论循环中脂肪素水平的升高、内脂素和鸢尾素水平的降低与NAFLD患病风险相关。展开更多
Adipose tissue is a dynamic endocrine organ that is essential to regulation of metabolism in humans. A new approach to mental disorders led to research oninvolvement of adipokines in the etiology of mental disorders a...Adipose tissue is a dynamic endocrine organ that is essential to regulation of metabolism in humans. A new approach to mental disorders led to research oninvolvement of adipokines in the etiology of mental disorders and mood states and their impact on the health status of psychiatric patients, as well as the effects of treatment for mental health disorders on plasma levels of adipokines. There is evidence that disturbances in adipokine secretion are important in the pathogenesis, clinical presentation and outcome of mental disorders. Admittedly leptin and adiponectin are involved in pathophysiology of depression. A lot of disturbances in secretion and plasma levels of adipokines are observed in eating disorders with a significant impact on the symptoms and course of a disease. It is still a question whether observed dysregulation of adipokines secretion are primary or secondary. Moreover findings in this area are somewhat inconsistent, owing to differences in patient age, sex, socioeconomic status, smoking habits, level of physical activity, eating pathology, general health or medication. This was the rationale for our detailed investigation into the role of the endocrine functions of adipose tissue in mental disorders. It seems that we are continually at the beginning of understanding of the relation between adipose tissue and mental disorders.展开更多
文摘目的探讨非酒精性脂肪肝(NAFLD)患者体内循环脂肪素(adipsin)、内脂素(visfatin)和鸢尾素(irisin)水平及其相关性。方法选取我院2018年1月至2019年12月门诊及住院的NAFLD患者120例和性别、年龄等一般情况相匹配的正常人120例,采集两组受试者血样,记录并分析其一般生化指标、血清adipsin、visfatin和irisin的浓度水平。测量并计算体质量指数(body mass index,BMI)和胰岛素抵抗指数(insulin resistance of homeostasis model assessment,HOMA-IR)。分析血清adipsin、visfatin和irisin水平与NAFLD发病的相关性。结果NAFLD患者BMI、TG、TC、AST、ALT、FBG、HOMR-IR、adipsin水平较对照组高,HDL-C、visfatin和irisin水平较对照组低(P<0.05)。NAFLD患者adipsin水平与BMI、FBG、FINS、HOMA-IR、TG呈正相关(P<0.05);NAFLD患者visfatin及irisin水平均与BMI、FBG、FINS、HOMA-IR、TG呈负相关(P<0.05)。按四分位法、最高四分位数组与最低四分位数组比较,adipsin、visfatin、adipsin与NAFLD患病风险的OR值分别为4.15(95%CI:1.18~14.66)、0.15(95%CI:0.05~0.53)和0.20(95%CI:0.06~0.71)。结论循环中脂肪素水平的升高、内脂素和鸢尾素水平的降低与NAFLD患病风险相关。
文摘Adipose tissue is a dynamic endocrine organ that is essential to regulation of metabolism in humans. A new approach to mental disorders led to research oninvolvement of adipokines in the etiology of mental disorders and mood states and their impact on the health status of psychiatric patients, as well as the effects of treatment for mental health disorders on plasma levels of adipokines. There is evidence that disturbances in adipokine secretion are important in the pathogenesis, clinical presentation and outcome of mental disorders. Admittedly leptin and adiponectin are involved in pathophysiology of depression. A lot of disturbances in secretion and plasma levels of adipokines are observed in eating disorders with a significant impact on the symptoms and course of a disease. It is still a question whether observed dysregulation of adipokines secretion are primary or secondary. Moreover findings in this area are somewhat inconsistent, owing to differences in patient age, sex, socioeconomic status, smoking habits, level of physical activity, eating pathology, general health or medication. This was the rationale for our detailed investigation into the role of the endocrine functions of adipose tissue in mental disorders. It seems that we are continually at the beginning of understanding of the relation between adipose tissue and mental disorders.
