The primary problem during the evolvement of next-generation Internet is the contradiction between growing requirements for Internet and the insufficient development of network theory and technology. As the fundamenta...The primary problem during the evolvement of next-generation Internet is the contradiction between growing requirements for Internet and the insufficient development of network theory and technology. As the fundamental principles to guide the developing direction of Internet, the study of Internet architecture is always a focus in the research community. To address the core issue of network scalability, we propose multi-dimension scalable architecture of next-generation Internet, the main idea of which is to extend the single-dimension scalability of traditional Internet on interconnection to multi-dimension scalability of next-generation Internet. The multi-dimension scalability is composed of scale-scalability, performance-scalability, security-scalability, function-scalability, and service-scalability. We suggest five elements, namely, IPv6, authentic IPv6 addressing, scalable processing capacity of routers, end-to-end connectionless Quality-of-Service control, and 4over6 mechanism to realize the multi-dimension scalability. The current research results show that the multi-dimension scalable architecture composed of these five elements will bring great influence on next-generation Internet.展开更多
In order to accommodate the variety of algorithms with different performance in specific application and improve power efficiency,reconfigurable architecture has become an effective methodology in academia and industr...In order to accommodate the variety of algorithms with different performance in specific application and improve power efficiency,reconfigurable architecture has become an effective methodology in academia and industry.However,existing architectures suffer from performance bottleneck due to slow updating of contexts and inadequate flexibility.This paper presents an H-tree based reconfiguration mechanism(HRM)with Huffman-coding-like and mask addressing method in a homogeneous processing element(PE)array,which supports both programmable and data-driven modes.The proposed HRM can transfer reconfiguration instructions/contexts to a particular PE or associated PEs simultaneously in one clock cycle in unicast,multicast and broadcast mode,and shut down the unnecessary PE/PEs according to the current configuration.To verify the correctness and efficiency,we implement it in RTL synthesis and FPGA prototype.Compared to prior works,the experiment results show that the HRM has improved the work frequency by an average of 23.4%,increased the updating speed by 2×,and reduced the area by 36.9%;HRM can also power off the unnecessary PEs which reduced 51%of dynamic power dissipation in certain application configuration.Furthermore,in the data-driven mode,the system frequency can reach 214 MHz,which is 1.68×higher compared with the programmable mode.展开更多
To ensure the extreme performances of the new 6G services,applications will be deployed at deep edge,resulting in a serious challenge of distributed application addressing.This paper traces back the latest development...To ensure the extreme performances of the new 6G services,applications will be deployed at deep edge,resulting in a serious challenge of distributed application addressing.This paper traces back the latest development of mobile network application addressing,analyzes two novel addressing methods in carrier network,and puts forward a 6G endogenous application addressing scheme by integrating some of their essence into the 6G network architecture,combining the new 6G capabilities of computing&network convergence,endogenous intelligence,and communication-sensing integration.This paper further illustrates how that the proposed method works in 6G networks and gives preliminary experimental verification.展开更多
The recently developed RNA-guided clustered regularly interspaced short palindromic repeat （CRISPR）/CRISPR-associated 9 （Cas9） nuclease system has progressed to be an invaluable technology for genome manipulation ...The recently developed RNA-guided clustered regularly interspaced short palindromic repeat （CRISPR）/CRISPR-associated 9 （Cas9） nuclease system has progressed to be an invaluable technology for genome manipulation in somatic cell types and germline model organisms. While the unprecedented advance in human embryo gene editing research has great potential in next-generation therapeutics, it raises various ethical concerns that need to be addressed before being translated for clinical use. Here, we discuss the current and potential applications of CRISPR/Cas9 technology and its limitations in clinical applications, as well as ethical and legal considerations in the treatment, disease prevention or disability in somatic cells or human embryo via gene editing.展开更多
The improvement of antibiotic rational use in China was studied by usage analysis of combination antibiotic therapy for type Ⅰ incisions in 244 hospitals. Five kinds of hospitals, including general hospital, maternit...The improvement of antibiotic rational use in China was studied by usage analysis of combination antibiotic therapy for type Ⅰ incisions in 244 hospitals. Five kinds of hospitals, including general hospital, maternity hospital, children＇s hospital, stomatological hospital and cancer hospital, from 30 provinces were surveyed. A systematic random sampling strategy was employed to select outpatient prescriptions and inpatient cases in 2011 and 2012. A total of 29 280 outpatient prescriptions and 73 200 inpatient cases from 244 hospitals in each year were analyzed. Data were collected with regards to the implementation of the national antibiotic stewardship program（NASP）, the overall usage and the prophylactic use of antibiotic for type Ⅰ incisions. Univariate analysis was used for microbiological diagnosis rate before antimicrobial therapy, prophylactic use of antibiotics for typeⅠincision operation, and so on. For multivariate analysis, the use of antibiotics was dichotomized according to the guidelines, and entered as binary values into logistic regression analysis. The results were compared with the corresponding criteria given by the guidelines of this campaign. The antibiotic stewardship in China was effective in that more than 80% of each kind of hospitals achieved the criteria of recommended antibiotics varieties. Hospital type appeared to be a factor statistically associated with stewardship outcome. The prophylactic use of antibiotics on type Ⅰ incision operations decreased by 16.22%（P〈0.05）. The usage of combination antibiotic therapy for type Ⅰ incisions was also decreased. Region and bed size were the main determinants on surgical prophylaxis for type Ⅰ incision. This national analysis of hospitals on antibiotic use and stewardship allows relevant comparisons for bench marking. More efforts addressing the root cause of antibiotics abuse would continue to improve the rational use of antibiotics in China.展开更多
Establishing positive and urgent targets for CO_2 reduction and emission peak,and promoting energy conservation and energy structure adjustment are among the strategies to address global climate change and CO_2 emissi...Establishing positive and urgent targets for CO_2 reduction and emission peak,and promoting energy conservation and energy structure adjustment are among the strategies to address global climate change and CO_2 emissions reduction.They are also means to break through the constraints of domestic resources and environment,and internal needs,to achieve sustainable development.Generally speaking,a country's CO_2 emission peak appears after achieving urbanization and industrialization.By then,connotative economic growth will appear,GDP will grow slowly,energy consumption elasticity will decrease,and energy consumption growth will slow down-dependent mainly on new and renewable energies.Fossil fuel consumption will not increase further.When CO_2 emission reaches its peak,the annual reduction rate of CO_2 intensity of GDP is greater than GDP annual growth rate;and the annual reduction rate of CO_2 intensity of energy use is greater than the annual growth rate of energy consumption.Therefore,three important approaches to promotion of CO_2 emission peak can be concluded:maintaining reasonable control of GDP growth,strengthening energy conservation to significantly reduce the GDP energy intensity,and optimizing the energy mix to reduce the CO_2 intensity of energy use.By around 2030,China will basically have completed its rapid development phase of industrialization and urbanization.Connotative economic growth will appear with the acceleration of industrial structure adjustment The target of GDP energy intensity will still be to maintain an average annual reduction of 3%or higher.The proportion of non-fossil fuels will reach 20-25%,and the aim will be to maintain an average annual growth rate of 6-8%.The total annual energy demand growth of 1.5%will be satisfied by the newly increased supply of non-fossil fuels.The annual decline in CO_2 intensity of GDP will reach 4.5%or higher,which is compatible with an average annual GDP growth rate of approximately 4.5%in order to reach CO_2 emission peak.This corresponds to the level展开更多
The effects of linear falling ramp reset pulse related to addressing operation in an alternating current plasma display panel （AC PDP） were studied. The wall charge waveforms were measured by the electrode balance m...The effects of linear falling ramp reset pulse related to addressing operation in an alternating current plasma display panel （AC PDP） were studied. The wall charge waveforms were measured by the electrode balance method in a 12-inch coplanar AC PDP. The wall charge waveforms show the relationship between the slope ratio of the falling ramp reset pulse and the wall charges at the end of the falling ramp reset pulse which influences the addressing stability. Then the effects of the slope ratio of the linear falling ramp reset pulse on the addressing voltage and addressing time were investigated. The experimental results show that the minimum addressing voltage increases with the increase of the slope ratio of the falling ramp reset pulse, and so does the minimum addressing time. Based on the experimental results, the optimization of the addressing time and the slope ratio of the falling ramp pulse is discussed.展开更多
基金This work is supported by the National Natural Science Foundation of China （Grant No. 90104002）, the National Grand Fundamental Research 973 Program of China （Grant No. 2003CB314801）.
文摘The primary problem during the evolvement of next-generation Internet is the contradiction between growing requirements for Internet and the insufficient development of network theory and technology. As the fundamental principles to guide the developing direction of Internet, the study of Internet architecture is always a focus in the research community. To address the core issue of network scalability, we propose multi-dimension scalable architecture of next-generation Internet, the main idea of which is to extend the single-dimension scalability of traditional Internet on interconnection to multi-dimension scalability of next-generation Internet. The multi-dimension scalability is composed of scale-scalability, performance-scalability, security-scalability, function-scalability, and service-scalability. We suggest five elements, namely, IPv6, authentic IPv6 addressing, scalable processing capacity of routers, end-to-end connectionless Quality-of-Service control, and 4over6 mechanism to realize the multi-dimension scalability. The current research results show that the multi-dimension scalable architecture composed of these five elements will bring great influence on next-generation Internet.
基金supported by the National Natural Science Foundation of China (Nos. 61834005, 61602377, 61772417, 61802304, 61874087)the Shaanxi International Science and Technology Cooperation Program No. 2018KW-006+1 种基金Shaanxi Provincial Key R&D Plan under Grant No. 2017GY-060Shaanxi Province Co-ordination Innovation Project of Science and Technology under Grant No. 2016KTZDGY02-04-02
文摘In order to accommodate the variety of algorithms with different performance in specific application and improve power efficiency,reconfigurable architecture has become an effective methodology in academia and industry.However,existing architectures suffer from performance bottleneck due to slow updating of contexts and inadequate flexibility.This paper presents an H-tree based reconfiguration mechanism(HRM)with Huffman-coding-like and mask addressing method in a homogeneous processing element(PE)array,which supports both programmable and data-driven modes.The proposed HRM can transfer reconfiguration instructions/contexts to a particular PE or associated PEs simultaneously in one clock cycle in unicast,multicast and broadcast mode,and shut down the unnecessary PE/PEs according to the current configuration.To verify the correctness and efficiency,we implement it in RTL synthesis and FPGA prototype.Compared to prior works,the experiment results show that the HRM has improved the work frequency by an average of 23.4%,increased the updating speed by 2×,and reduced the area by 36.9%;HRM can also power off the unnecessary PEs which reduced 51%of dynamic power dissipation in certain application configuration.Furthermore,in the data-driven mode,the system frequency can reach 214 MHz,which is 1.68×higher compared with the programmable mode.
基金supported by the National Key R&D Program of China(Project Number:2022YFB2902100).
文摘To ensure the extreme performances of the new 6G services,applications will be deployed at deep edge,resulting in a serious challenge of distributed application addressing.This paper traces back the latest development of mobile network application addressing,analyzes two novel addressing methods in carrier network,and puts forward a 6G endogenous application addressing scheme by integrating some of their essence into the 6G network architecture,combining the new 6G capabilities of computing&network convergence,endogenous intelligence,and communication-sensing integration.This paper further illustrates how that the proposed method works in 6G networks and gives preliminary experimental verification.
文摘The recently developed RNA-guided clustered regularly interspaced short palindromic repeat （CRISPR）/CRISPR-associated 9 （Cas9） nuclease system has progressed to be an invaluable technology for genome manipulation in somatic cell types and germline model organisms. While the unprecedented advance in human embryo gene editing research has great potential in next-generation therapeutics, it raises various ethical concerns that need to be addressed before being translated for clinical use. Here, we discuss the current and potential applications of CRISPR/Cas9 technology and its limitations in clinical applications, as well as ethical and legal considerations in the treatment, disease prevention or disability in somatic cells or human embryo via gene editing.
基金supported by the Major Program of National Fund of Philosophy and Social Science of China(No.15ZDC037)
文摘The improvement of antibiotic rational use in China was studied by usage analysis of combination antibiotic therapy for type Ⅰ incisions in 244 hospitals. Five kinds of hospitals, including general hospital, maternity hospital, children＇s hospital, stomatological hospital and cancer hospital, from 30 provinces were surveyed. A systematic random sampling strategy was employed to select outpatient prescriptions and inpatient cases in 2011 and 2012. A total of 29 280 outpatient prescriptions and 73 200 inpatient cases from 244 hospitals in each year were analyzed. Data were collected with regards to the implementation of the national antibiotic stewardship program（NASP）, the overall usage and the prophylactic use of antibiotic for type Ⅰ incisions. Univariate analysis was used for microbiological diagnosis rate before antimicrobial therapy, prophylactic use of antibiotics for typeⅠincision operation, and so on. For multivariate analysis, the use of antibiotics was dichotomized according to the guidelines, and entered as binary values into logistic regression analysis. The results were compared with the corresponding criteria given by the guidelines of this campaign. The antibiotic stewardship in China was effective in that more than 80% of each kind of hospitals achieved the criteria of recommended antibiotics varieties. Hospital type appeared to be a factor statistically associated with stewardship outcome. The prophylactic use of antibiotics on type Ⅰ incision operations decreased by 16.22%（P〈0.05）. The usage of combination antibiotic therapy for type Ⅰ incisions was also decreased. Region and bed size were the main determinants on surgical prophylaxis for type Ⅰ incision. This national analysis of hospitals on antibiotic use and stewardship allows relevant comparisons for bench marking. More efforts addressing the root cause of antibiotics abuse would continue to improve the rational use of antibiotics in China.
基金supported by Major programs of humanities and social science base,Ministry of Education[grant number10JJD630011]
文摘Establishing positive and urgent targets for CO_2 reduction and emission peak,and promoting energy conservation and energy structure adjustment are among the strategies to address global climate change and CO_2 emissions reduction.They are also means to break through the constraints of domestic resources and environment,and internal needs,to achieve sustainable development.Generally speaking,a country's CO_2 emission peak appears after achieving urbanization and industrialization.By then,connotative economic growth will appear,GDP will grow slowly,energy consumption elasticity will decrease,and energy consumption growth will slow down-dependent mainly on new and renewable energies.Fossil fuel consumption will not increase further.When CO_2 emission reaches its peak,the annual reduction rate of CO_2 intensity of GDP is greater than GDP annual growth rate;and the annual reduction rate of CO_2 intensity of energy use is greater than the annual growth rate of energy consumption.Therefore,three important approaches to promotion of CO_2 emission peak can be concluded:maintaining reasonable control of GDP growth,strengthening energy conservation to significantly reduce the GDP energy intensity,and optimizing the energy mix to reduce the CO_2 intensity of energy use.By around 2030,China will basically have completed its rapid development phase of industrialization and urbanization.Connotative economic growth will appear with the acceleration of industrial structure adjustment The target of GDP energy intensity will still be to maintain an average annual reduction of 3%or higher.The proportion of non-fossil fuels will reach 20-25%,and the aim will be to maintain an average annual growth rate of 6-8%.The total annual energy demand growth of 1.5%will be satisfied by the newly increased supply of non-fossil fuels.The annual decline in CO_2 intensity of GDP will reach 4.5%or higher,which is compatible with an average annual GDP growth rate of approximately 4.5%in order to reach CO_2 emission peak.This corresponds to the level
基金supported by the 2002 Ministry of Education Project for Science and Technology (2002,No.77)
文摘The effects of linear falling ramp reset pulse related to addressing operation in an alternating current plasma display panel （AC PDP） were studied. The wall charge waveforms were measured by the electrode balance method in a 12-inch coplanar AC PDP. The wall charge waveforms show the relationship between the slope ratio of the falling ramp reset pulse and the wall charges at the end of the falling ramp reset pulse which influences the addressing stability. Then the effects of the slope ratio of the linear falling ramp reset pulse on the addressing voltage and addressing time were investigated. The experimental results show that the minimum addressing voltage increases with the increase of the slope ratio of the falling ramp reset pulse, and so does the minimum addressing time. Based on the experimental results, the optimization of the addressing time and the slope ratio of the falling ramp pulse is discussed.
