Purpose To explore the potential of X-ray imaging for early-stage lung cancer screening and to help finding an optimal lung cancer screening method.Methods Experimentally and simulatively comparing performances of dif...Purpose To explore the potential of X-ray imaging for early-stage lung cancer screening and to help finding an optimal lung cancer screening method.Methods Experimentally and simulatively comparing performances of different X-ray techniques(absorption-contrast imaging and phase-contrast imaging)for model lung cancer samples.Results Absorption imaging shows performance equal to or better than that of low-radiation dose.Conclusion Absorption imaging is still the most promising imaging method for early lung cancer detection.展开更多
Diffraction enhanced imaging （DEI） with edge enhancement is suitable for the observation of weakly absorbing objects. The potential ability of the DEI was explored for displaying the microanatomy and pathology of hu...Diffraction enhanced imaging （DEI） with edge enhancement is suitable for the observation of weakly absorbing objects. The potential ability of the DEI was explored for displaying the microanatomy and pathology of human eyeball in this work. The images of surgical specimens from malignant intraocular tumor of hospitalized patients were taken using the hard X-rays from the topography station of Beamline 4W1A at Beijing Synchrotron Radiation Facility （BSRF）. The obtained radiographic images were analyzed in correlation with those of pathology. The results show that the anatomic and pathologic details of intraocular tumors in human beings can be observed clearly by DEI for the first time, with good visualization of the microscopic details of eyeball ring such as sclera, choroids and other details of intraocular organelles. And the best resolution of DEI images reaches up to the magnitude of several tens of μm. The results suggest that it is capable of exhibiting clearly the details of intraocular tumor using DEI method.展开更多
基金We sincerely appreciated the kind assistance of the staff of the 4W1A beamline of the Beijing Synchrotron Radiation Facility and the BL13W1 beamline of the Shanghai Synchrotron Radi-ation Facility.Our researches are funded by NSFC 11305200NSFC U1732108NSFC 11675208 and NSFC 11627901。
文摘Purpose To explore the potential of X-ray imaging for early-stage lung cancer screening and to help finding an optimal lung cancer screening method.Methods Experimentally and simulatively comparing performances of different X-ray techniques(absorption-contrast imaging and phase-contrast imaging)for model lung cancer samples.Results Absorption imaging shows performance equal to or better than that of low-radiation dose.Conclusion Absorption imaging is still the most promising imaging method for early lung cancer detection.
基金Shanghai Key Discipline Fund(No.P0502)Shanghai Scientific and Technological Development Fund(No.07ZZ93)+2 种基金Shanghai Major Research projects Fund(No.06DZ11311)Shanghai Science and Technology Special Project of Talent Program Topics (No.09QT1405900)Shanghai Universities Select And Train Outstanding Young Teachers In Special Fund(No.slg08044)
基金Supported by National Natural Science Foundation (10490195)Key Project of Chinese National Programs for Fundamental Research and Development (973 program) (2006cb500700)Natural Science and Technology Foundation of Guangdong Province(04009356,2008B030301320)
文摘Diffraction enhanced imaging （DEI） with edge enhancement is suitable for the observation of weakly absorbing objects. The potential ability of the DEI was explored for displaying the microanatomy and pathology of human eyeball in this work. The images of surgical specimens from malignant intraocular tumor of hospitalized patients were taken using the hard X-rays from the topography station of Beamline 4W1A at Beijing Synchrotron Radiation Facility （BSRF）. The obtained radiographic images were analyzed in correlation with those of pathology. The results show that the anatomic and pathologic details of intraocular tumors in human beings can be observed clearly by DEI for the first time, with good visualization of the microscopic details of eyeball ring such as sclera, choroids and other details of intraocular organelles. And the best resolution of DEI images reaches up to the magnitude of several tens of μm. The results suggest that it is capable of exhibiting clearly the details of intraocular tumor using DEI method.
