We used satellite altimetry data to investigate the Kuroshio Current because of the higher resolution and wider range of observations. In previous studies, satellite absolute geostrophic velocities were used to study ...We used satellite altimetry data to investigate the Kuroshio Current because of the higher resolution and wider range of observations. In previous studies, satellite absolute geostrophic velocities were used to study the spatiotemporal variability of the sea surface velocity field along the current, and extraction methods were employed to detect the Kuroshio axes and paths. However, sea surface absolute geostrophic velocity estimated from absolute dynamic topography should be regarded as the geostrophic component of the actual surface velocity, which cannot represent a sea surface current accurately. In this study, mathematical verification between the climatic absolute geostrophic and bin-averaged drifting buoy velocity was established and then adopted to correct the satellite absolute geostrophic velocities. There were some differences in the characteristics between satellite geostrophic and drifting buoy velocities. As a result, the corrected satellite absolute geostrophic velocities were used to detect the Kuroshio axis and path based on a principal-component detection scheme. The results showed that the detection of the Kuroshio axes and paths from corrected absolute geostrophic velocities performed better than those from satellite absolute geostrophic velocities and surface current estimations. The corrected satellite absolute geostrophic velocity may therefore contribute to more precise day-to-day detection of the Kuroshio Current axis and path.展开更多
基金The National Science and Technology Major Project of the Ministry of Science and Technology of China under contract No.2018YFF01014100the National Programme on Global Change and Air-Sea Interaction under contract No.GASI-IPOVAI-01-05the NSFC-Shandong Joint Fund for Marine Science Research Centers under contract No.U1606405
文摘We used satellite altimetry data to investigate the Kuroshio Current because of the higher resolution and wider range of observations. In previous studies, satellite absolute geostrophic velocities were used to study the spatiotemporal variability of the sea surface velocity field along the current, and extraction methods were employed to detect the Kuroshio axes and paths. However, sea surface absolute geostrophic velocity estimated from absolute dynamic topography should be regarded as the geostrophic component of the actual surface velocity, which cannot represent a sea surface current accurately. In this study, mathematical verification between the climatic absolute geostrophic and bin-averaged drifting buoy velocity was established and then adopted to correct the satellite absolute geostrophic velocities. There were some differences in the characteristics between satellite geostrophic and drifting buoy velocities. As a result, the corrected satellite absolute geostrophic velocities were used to detect the Kuroshio axis and path based on a principal-component detection scheme. The results showed that the detection of the Kuroshio axes and paths from corrected absolute geostrophic velocities performed better than those from satellite absolute geostrophic velocities and surface current estimations. The corrected satellite absolute geostrophic velocity may therefore contribute to more precise day-to-day detection of the Kuroshio Current axis and path.
文摘目的研究桃核承气汤延缓肾间质纤维化(renal intersitial fibrosis,RIF)的分子机制。方法30只SPF级健康wistar雄性大鼠,随机分为假手术组、模型组、药物组,每组10只;假手术组游离单侧输尿管,模型组及药物组采用单侧输尿管梗阻方法建立RIF模型。假手术组、模型组、药物组自术后第一天开始,分别灌服5 mL蒸馏水、5 mL蒸馏水、5 mL桃核承气汤,每日一次。14天后取梗阻侧肾组织,用绝对和相对定量同位素标记(isobaric tags for relative and absolute quantification,iTRAQ)技术筛选差异蛋白,进行蛋白质组学检测,基因本体(gene ontology,GO)分析、京都基因和基因组百科全书(Kyoto Encyclopedia of Genes and Genomes,KEGG)比对及聚类分析。结果桃核承气汤具有延缓单侧输卵管梗阻造成RIF的作用;药物组与模型组相比筛选的差异蛋白共343种,其中与RIF密切相关的蛋白16种,11种蛋白表达上调,5种蛋白表达下调。GO分析主要涉及氧化还原、药物代谢等生物学过程;线粒体基质、线粒体内膜等细胞组分;氧化还原酶活性等分子功能,KEGG分析涉及AMPK、FoxO/Wnt、PPAR、HIF-1等多条信号通路。结论桃核承气汤延缓肾间质纤维化的分子机制可能与调节磷酸烯醇式丙酮酸羧基酶1(phosphoenolpyruvate carboxykinase 1,PCK1)等蛋白,影响AMPK、FoxO/Wnt、PPAR、HIF-1等信号通路相关。
