目的探讨肝硬化患者血清学指标在肝硬化并发原发性肝癌诊断中的价值。方法收集2012年1月-2013年12月入住我院消化内科的肝硬化患者89例,其中肝硬化并发原发性肝癌(PHCC)23例,单纯性肝硬化(HC)66例。根据纳入与排除标准,最终选择55例患...目的探讨肝硬化患者血清学指标在肝硬化并发原发性肝癌诊断中的价值。方法收集2012年1月-2013年12月入住我院消化内科的肝硬化患者89例,其中肝硬化并发原发性肝癌(PHCC)23例,单纯性肝硬化(HC)66例。根据纳入与排除标准,最终选择55例患者作为研究对象(PHCC组14例,HC组41例)。所有患者均行血常规、肝功能、电解质、凝血指标、甲胎蛋白及肝炎标志物检查。结果 2组患者流行病学资料未见明显差异,PHCC组患者血清AFP水平显著地高于HC组患者(737.89±197.21 vs 54.29±10.08,P=0.003),与HC组患者相比,PHCC组患者AST/ALT比值(1.76±1.05 vs 1.25±0.49,P=0.018)和GGT/ALT比值(6.70±10.92 vs 2.84±3.29,P=0.047)均显著增高。在肝硬化并发原发性肝癌的诊断中,AST/ALT的敏感性为64.3%,特异性73.2%(cutoff值1.43);GGT/ALT敏感性为42.9%,特异性为85.4%(cutoff值3.72)。结论肝硬化并发原发性肝癌患者血清AFP水平显著升高,联合AST/ALT比值、GGT/ALT比值检测能够提高肝硬化患者并发原发性肝癌的检出率。展开更多
Objective The beneficial effects of silymarin have been extensively studied in the context of inflammation and cancer treatment, yet much less is known about its therapeutic effect on diabetes. The present study was a...Objective The beneficial effects of silymarin have been extensively studied in the context of inflammation and cancer treatment, yet much less is known about its therapeutic effect on diabetes. The present study was aimed to investigate the cytoprotective activity of silymarin against diabetes-induced cardiomyocyte apoptosis. Methods Rats were randomly divided into： control group, untreated diabetes group and diabetes group treated with silymarin （120 mg/ks·d） for 10 d. Rats were sacrificed, and the cardiac muscle specimens and blood samples were collected. The immunoreactivity of caspase-3 and Bcl-2 in the cardiomyocytes was measured. Total proteins, glucose, insulin, creatinine, AST, ALT, cholesterol, and triglycerides levels were estimated. Results Unlike the treated diabetes group, cardiomyocyte apoptosis increased in the untreated rats, as evidenced by enhanced caspase-3 and declined Bcl-2 activities. The levels of glucose, creatinine, AST, ALT, cholesterol, and triglycerides declined in the treated rats. The declined levels of insulin were enhanced again after treatment of diabetic rats with silymarin, reflecting a restoration of the pancreatic β-cells activity. Conclusion The findings of this study are of great importance, which confirmed for the first time that treatment of diabetic subjects with silymarin may protect cardiomyocytes against apoptosis and promote survival-restoration of the pancreatic β-cells.展开更多
Objective: The aim of the study is to investigate the “new-onset jaundice” incidence, map of causes, approaching method, and risk factors for treatment failure in adult in-patients at a tertiary general hospital as ...Objective: The aim of the study is to investigate the “new-onset jaundice” incidence, map of causes, approaching method, and risk factors for treatment failure in adult in-patients at a tertiary general hospital as Cho Ray Hospital, Ho Chi Minh City, Viet Nam. Method: Retrospective study was done on 416 jaundice patients administered over 38 continuous days. Laboratory tests investigated were total bilirubin, direct bilirubin, AST, ALT, AST/ALT ratio, GGT, AP, bilirubin and urobilinogen in urine. Jaundice was defined as total bilirubin ≥ 2.5 mg/dL, direct bilirubin jaundice defined as direct bilirubin > 2 mg/dL and D/T percentage > 60%, the severity of AST, ALT evaluated according to Common Terminology Criteria for Adverse Events, AST/ALT ratio, and bilirubin, urobilinogen in urine. Outcome of treatment were classified in two groups: failure (dead or discharge due to worse status) and success. Descriptive statistics and analytic statistics were applied, mono-variable analysis and multinomial logistic regression to find out the independent risk factors for treatment failure. Results: The incidence of “new-onset” jaundice in adult patients was 11 ± 5 person/day. The map of jaundice included 3 phases as pre-heaptic 13.7%, in-hepatic 58.2%, and post-hepatic 22.8%. Pancreatic and biliary tract diseases accounted 17.1%, then cirrhosis 16.3%, liver tumor 14.7%, hepatitis 8.9%, sepsis 8.9%, hematology diseases 7.9%, and cardiac diseases 7.5%. A guide for approaching causes of jaundice basing on 7 parameters as total bilirubin, D/T percentage, severity of ALT, AST/ALT ratio, severity of GGT, and bilirubin and urobilinogen in urine was established. The overall mortality was 7.5% (31/416), sepsis had highest death rate of 37.8% (14/37). Sepsis and AST/ALT ratio > 2 were the two independent risk factors of mortality. Conclusion: At tertiary hospital, jaundice is common sign in adult patient, diverse enormously in many clinical wards. The map of causes of jaundice completed all 3 phases: pre-hepatic, intra-hepatic 展开更多
文摘目的探讨肝硬化患者血清学指标在肝硬化并发原发性肝癌诊断中的价值。方法收集2012年1月-2013年12月入住我院消化内科的肝硬化患者89例,其中肝硬化并发原发性肝癌(PHCC)23例,单纯性肝硬化(HC)66例。根据纳入与排除标准,最终选择55例患者作为研究对象(PHCC组14例,HC组41例)。所有患者均行血常规、肝功能、电解质、凝血指标、甲胎蛋白及肝炎标志物检查。结果 2组患者流行病学资料未见明显差异,PHCC组患者血清AFP水平显著地高于HC组患者(737.89±197.21 vs 54.29±10.08,P=0.003),与HC组患者相比,PHCC组患者AST/ALT比值(1.76±1.05 vs 1.25±0.49,P=0.018)和GGT/ALT比值(6.70±10.92 vs 2.84±3.29,P=0.047)均显著增高。在肝硬化并发原发性肝癌的诊断中,AST/ALT的敏感性为64.3%,特异性73.2%(cutoff值1.43);GGT/ALT敏感性为42.9%,特异性为85.4%(cutoff值3.72)。结论肝硬化并发原发性肝癌患者血清AFP水平显著升高,联合AST/ALT比值、GGT/ALT比值检测能够提高肝硬化患者并发原发性肝癌的检出率。
文摘Objective The beneficial effects of silymarin have been extensively studied in the context of inflammation and cancer treatment, yet much less is known about its therapeutic effect on diabetes. The present study was aimed to investigate the cytoprotective activity of silymarin against diabetes-induced cardiomyocyte apoptosis. Methods Rats were randomly divided into： control group, untreated diabetes group and diabetes group treated with silymarin （120 mg/ks·d） for 10 d. Rats were sacrificed, and the cardiac muscle specimens and blood samples were collected. The immunoreactivity of caspase-3 and Bcl-2 in the cardiomyocytes was measured. Total proteins, glucose, insulin, creatinine, AST, ALT, cholesterol, and triglycerides levels were estimated. Results Unlike the treated diabetes group, cardiomyocyte apoptosis increased in the untreated rats, as evidenced by enhanced caspase-3 and declined Bcl-2 activities. The levels of glucose, creatinine, AST, ALT, cholesterol, and triglycerides declined in the treated rats. The declined levels of insulin were enhanced again after treatment of diabetic rats with silymarin, reflecting a restoration of the pancreatic β-cells activity. Conclusion The findings of this study are of great importance, which confirmed for the first time that treatment of diabetic subjects with silymarin may protect cardiomyocytes against apoptosis and promote survival-restoration of the pancreatic β-cells.
文摘Objective: The aim of the study is to investigate the “new-onset jaundice” incidence, map of causes, approaching method, and risk factors for treatment failure in adult in-patients at a tertiary general hospital as Cho Ray Hospital, Ho Chi Minh City, Viet Nam. Method: Retrospective study was done on 416 jaundice patients administered over 38 continuous days. Laboratory tests investigated were total bilirubin, direct bilirubin, AST, ALT, AST/ALT ratio, GGT, AP, bilirubin and urobilinogen in urine. Jaundice was defined as total bilirubin ≥ 2.5 mg/dL, direct bilirubin jaundice defined as direct bilirubin > 2 mg/dL and D/T percentage > 60%, the severity of AST, ALT evaluated according to Common Terminology Criteria for Adverse Events, AST/ALT ratio, and bilirubin, urobilinogen in urine. Outcome of treatment were classified in two groups: failure (dead or discharge due to worse status) and success. Descriptive statistics and analytic statistics were applied, mono-variable analysis and multinomial logistic regression to find out the independent risk factors for treatment failure. Results: The incidence of “new-onset” jaundice in adult patients was 11 ± 5 person/day. The map of jaundice included 3 phases as pre-heaptic 13.7%, in-hepatic 58.2%, and post-hepatic 22.8%. Pancreatic and biliary tract diseases accounted 17.1%, then cirrhosis 16.3%, liver tumor 14.7%, hepatitis 8.9%, sepsis 8.9%, hematology diseases 7.9%, and cardiac diseases 7.5%. A guide for approaching causes of jaundice basing on 7 parameters as total bilirubin, D/T percentage, severity of ALT, AST/ALT ratio, severity of GGT, and bilirubin and urobilinogen in urine was established. The overall mortality was 7.5% (31/416), sepsis had highest death rate of 37.8% (14/37). Sepsis and AST/ALT ratio > 2 were the two independent risk factors of mortality. Conclusion: At tertiary hospital, jaundice is common sign in adult patient, diverse enormously in many clinical wards. The map of causes of jaundice completed all 3 phases: pre-hepatic, intra-hepatic
