哺乳动物精子获能是精卵成功结合的前提。精子获能时,胞内环磷酸腺苷(cAMP)、环磷酸尿苷(cGMP)浓度显著升高,调节精子活力及顶体反应。精子中cAMP作用于cAMP依赖性蛋白激酶(cAMP dependent protein kinase,PKA),通过蛋白质磷酸化作用传...哺乳动物精子获能是精卵成功结合的前提。精子获能时,胞内环磷酸腺苷(cAMP)、环磷酸尿苷(cGMP)浓度显著升高,调节精子活力及顶体反应。精子中cAMP作用于cAMP依赖性蛋白激酶(cAMP dependent protein kinase,PKA),通过蛋白质磷酸化作用传递信息;cGMP与cGMP依赖性蛋白激酶(cGMP dependent protein kinase,PKG)、环核苷酸门控离子通道(cyclicnucleotide gated ion channel,CNG)、磷酸二酯酶(phosphodiesteras,PDEs)等蛋白结合,调控信号通路;Ca2+、HCO3-等离子通道同样与精子获能关系密切。展开更多
Signal transduction across cell membranes is an important subject of the current studies on biomembranes. Hormonally regulated adenylate cyclase signalling system is composed of three distinct types of plasma-membrane...Signal transduction across cell membranes is an important subject of the current studies on biomembranes. Hormonally regulated adenylate cyclase signalling system is composed of three distinct types of plasma-membrane associated proteins: the receptor, adenylate cyclase (AC) and stimulatory GTP-binding protein (Gs) which me-展开更多
Catecholamines such as adrenaline, norepinephrine and isoproterenol regulate a wide variety of physiological responses via their specific binding to adrenergic receptors located in the plasma membrane. Adrenergic rece...Catecholamines such as adrenaline, norepinephrine and isoproterenol regulate a wide variety of physiological responses via their specific binding to adrenergic receptors located in the plasma membrane. Adrenergic receptors have been divided into two major types, α and β. Binding of ligands to β-adrenergic receptors (β-AR) first triggers the activation of stimulatory GTP-binding protein (Gs). The activated Gs then interacts展开更多
文摘哺乳动物精子获能是精卵成功结合的前提。精子获能时,胞内环磷酸腺苷(cAMP)、环磷酸尿苷(cGMP)浓度显著升高,调节精子活力及顶体反应。精子中cAMP作用于cAMP依赖性蛋白激酶(cAMP dependent protein kinase,PKA),通过蛋白质磷酸化作用传递信息;cGMP与cGMP依赖性蛋白激酶(cGMP dependent protein kinase,PKG)、环核苷酸门控离子通道(cyclicnucleotide gated ion channel,CNG)、磷酸二酯酶(phosphodiesteras,PDEs)等蛋白结合,调控信号通路;Ca2+、HCO3-等离子通道同样与精子获能关系密切。
文摘Signal transduction across cell membranes is an important subject of the current studies on biomembranes. Hormonally regulated adenylate cyclase signalling system is composed of three distinct types of plasma-membrane associated proteins: the receptor, adenylate cyclase (AC) and stimulatory GTP-binding protein (Gs) which me-
文摘Catecholamines such as adrenaline, norepinephrine and isoproterenol regulate a wide variety of physiological responses via their specific binding to adrenergic receptors located in the plasma membrane. Adrenergic receptors have been divided into two major types, α and β. Binding of ligands to β-adrenergic receptors (β-AR) first triggers the activation of stimulatory GTP-binding protein (Gs). The activated Gs then interacts
