A general, mild and efficient protocol for the synthesis of ethyl 4-methyl-2-（thiophen）-2,5-dihydro-1,5- benzodiazepine-3-carboxylate is achieved for first time using H3PMo12O40 in ethanol at 0 ℃ by a one- pot, th...A general, mild and efficient protocol for the synthesis of ethyl 4-methyl-2-（thiophen）-2,5-dihydro-1,5- benzodiazepine-3-carboxylate is achieved for first time using H3PMo12O40 in ethanol at 0 ℃ by a one- pot, three-component condensation of various thiophene aldehydes, substituted o-phenylenediamines and ethyl acetoacetate. Compared with the conventional synthesis method, this procedure has the advantages of convenient operation, excellent yields, and environmentally benign. A plausible formation mechanism has been proposed. The structure of the products is characterized by1H NMR, IR, MS and elemental analysis.展开更多
基金financial support from the National Natural Science Foundation of China(No.21276064)the Natural Science Foundation of Hebei Education Department(No.2008320)the Science Foundation of Hebei Normal University(No.2011Y04)
文摘A general, mild and efficient protocol for the synthesis of ethyl 4-methyl-2-（thiophen）-2,5-dihydro-1,5- benzodiazepine-3-carboxylate is achieved for first time using H3PMo12O40 in ethanol at 0 ℃ by a one- pot, three-component condensation of various thiophene aldehydes, substituted o-phenylenediamines and ethyl acetoacetate. Compared with the conventional synthesis method, this procedure has the advantages of convenient operation, excellent yields, and environmentally benign. A plausible formation mechanism has been proposed. The structure of the products is characterized by1H NMR, IR, MS and elemental analysis.
