AIM: To search candidate tumor suppressor genes (TSGs) on chromosome 4q through detecting high loss of heterozygosity (LOH) regions in sporadic colorectal carcinoma in Chinese patients. METHODS: Thirteen fluorescent l...AIM: To search candidate tumor suppressor genes (TSGs) on chromosome 4q through detecting high loss of heterozygosity (LOH) regions in sporadic colorectal carcinoma in Chinese patients. METHODS: Thirteen fluorescent labeled polymorphic microsatellite markers were analyzed in 83 cases of colorectal carcinoma and matched normal tissue DNA by polymerase chain reaction (PCR). PCR products were eletrophoresed on an ABI 377 DNA sequencer. Genescan 3.7 and Genotype 3.7 software were used for LOH scanning and analysis. Comparison between LOH frequency and clinicopathological factors were performed by χ2 test. RESULTS: Data were collected on all informative loci. The average LOH frequency on 4q was 28.56%. The D4S2915 locus showed highest LOH frequency (36.17%). Two obvious deletion regions were detected: one between D4S3000 and D4S2915 locus (4q12-21.1), another flanked by D4S407 and D4S2939 locus (4q25-31.1). None case showed complete deletion of 4q, most cases displayed interstitial deletion pattern solely. Furthermore, compared with clinicopathological features, a significant relationship was observed between LOH frequencies on D4S3018locus. In tumors larger than 5 cm in diameter, LOH frequency was significantly higher than tumors that were less than 5 cm (56% vs 13.79%, P = 0.01). On D4S1534 locus, LOH was significantly associated with liver metastasis (80% vs 17.25%, P = 0.012). No relationship was detected on other locus compared with clinicopathologial features. CONCLUSION: By high resolution deletion mapping, two high frequency regions of LOH (4q12-21.1 and 4q25-31.1) were detected, which may contribute to locate TSGs on chromosome 4q involved in carcinogenesis and progression of sporadic colorectal carcinoma.展开更多
The paper deals with the power quality analysis of interlaced four quadrant (4Q) converters with constant switching frequency. These are in fact the input stages of the locomotives and high speed trains supplied by 25...The paper deals with the power quality analysis of interlaced four quadrant (4Q) converters with constant switching frequency. These are in fact the input stages of the locomotives and high speed trains supplied by 25 kV, 50 Hz and 15 kV, 16.7 Hz lines. Due to the high power needed for the trains circulation, the 4Q converter can absorb distorted currents, whose harmonic content can affect the signaling systems and communication devices. The presence of more converters gives the opportunity, using dedicated commutation strategy, to interlace them in order to reduce the harmonic content in the absorbed current. In the paper a suitable model of more 4Q converters is developed. The control logic implemented in the model allows the evaluation of the harmonic contribution of both single converter and the interlaced configuration. The analysis is carried out through electromagnetic transient simulations.展开更多
License plate recognition system plays an important role in many applications. An automatic recognizer for Iraqi License Plates using ELMAN Neural network is proposed in this manuscript. The processing procedures are ...License plate recognition system plays an important role in many applications. An automatic recognizer for Iraqi License Plates using ELMAN Neural network is proposed in this manuscript. The processing procedures are developed in several stages. Experimental results are reported in the end of the paper to illustrate the performance of the proposed method.展开更多
Adaptive noise data filtering in real-time requires dedicated hardware to meet demanding time requirements. Both DSP processors and FPGAs were studied with respect to their performance in power consumption, hardware a...Adaptive noise data filtering in real-time requires dedicated hardware to meet demanding time requirements. Both DSP processors and FPGAs were studied with respect to their performance in power consumption, hardware architecture, and speed for real time applications. For testing purposes, real time adaptive noise filters have been implemented and simulated on two different platforms, Motorola DSP56303 EVM and Xilinx Spartan III boards. This study has shown that in high speed applications, FPGAs are advantageous over DSPs with respect of their speed and noise reduction because of their parallel architecture. FPGAs can handle more processes at the same time when compared to DSPs, while the later can only handle a limited number of parallel instructions at a time. The speed in both processors impacts the noise reduction in real time. As the DSP core gets slower, the noise removal in real time gets harder to achieve. With respect to power, DSPs are advantageous over FPGAs. FPGAs have reconfigurable gate structure which consumes more power. In case of DSPs, the hardware has been already configured, which requires less power consumption? FPGAs are built for general purposes, and their silicon area in the core is bigger than that of DSPs. This is another factor that affects power consumption. As a result, in high frequency applications, FPGAs are advantageous as compared to DSPs. In low frequency applications, DSPs and FPGAs both satisfy the requirements for noise cancelling. For low frequency applications, DSPs are advantageous in their power consumption and applications for the battery power devices. Software utilizing Matlab, VHDL code run on Xilinix system, and assembly running on Motorola development systems, have been used for the demonstration of this study.展开更多
Primary intestinal lymphangiectasia(PIL)is a rare disorder characterized by dilated intestinal lymphatics and the development of protein-losing enteropathy.Patients with PIL develop hypoalbuminemia,hypocalcemia,lympho...Primary intestinal lymphangiectasia(PIL)is a rare disorder characterized by dilated intestinal lymphatics and the development of protein-losing enteropathy.Patients with PIL develop hypoalbuminemia,hypocalcemia,lymphopenia and hypogammaglobulinemia,and present with bilateral lower limb edema,fatigue,abdominal pain and diarrhea.Endoscopy reveals diffusely elongated,circumferential and polypoid mucosae covered with whitish enlarged villi,all of which indicate intestinal lymphangiectasia.Diagnosis is conf irmed by characteristic tissue pathology,which includes dilated intestinal lymphatics with diffusely swollen mucosa and enlarged villi.The prevalence of PIL has increased since the introduction of capsule endoscopy.The etiology and prevalence of PIL remain unknown.Some studies have reported that several genes and regulatory molecules for lymphangiogenesis are related to PIL.We report the case of a patient with PIL involving the entire small bowel that was confirmed by capsule endoscopy and double-balloon enteroscopy-guided tissue pathology who carried a deletion on chromosome 4q25.The relationship between this deletion on chromosome 4 and PIL remains to be investigated.展开更多
将杯[4]醌(Calix[4]quinone,C4Q)通过灌注法与有序介孔炭CMK-3制备成纳米复合材料,可抑制其在常规有机电解液中的溶解。为了进一步提升其电化学性能,本文在C4Q/CMK-3复合材料中加入单壁碳纳米管(SWCNTs),减少了CMK-3的用量,并代替导电炭...将杯[4]醌(Calix[4]quinone,C4Q)通过灌注法与有序介孔炭CMK-3制备成纳米复合材料,可抑制其在常规有机电解液中的溶解。为了进一步提升其电化学性能,本文在C4Q/CMK-3复合材料中加入单壁碳纳米管(SWCNTs),减少了CMK-3的用量,并代替导电炭黑Super-P作为导电剂,通过脱泡搅拌法制备了C4Q/CMK-3/SWCNTs复合材料。研究表明,当m(C4Q)∶m(CMK-3)∶m(SWCNTs)为1∶1∶1时,电化学性能最佳,0. 1 C电流密度下循环100圈后,电池的容量保持为238. 7 m A·h/g,当电流密度增大到1 C时,放电容量仍有260 m A·h/g,这是由于SWCNTs在复合材料C4Q/CMK-3中构建了三维导电网络,增强了电极的稳定性,降低了电池内阻,从而提升了电池的循环性能与倍率性能。展开更多
设计了激光二极管侧面泵浦两级放大电光调Q全固态Nd∶YAG激光器,实现间距可调的脉冲序列激光输出。使用U型封装的LD模块对晶体棒进行侧面泵浦,磷酸钛氧铷（RTP）晶体作为调Q晶体,通过提供调Q高压序列,获得了单个脉冲能量大于550 m J,脉...设计了激光二极管侧面泵浦两级放大电光调Q全固态Nd∶YAG激光器,实现间距可调的脉冲序列激光输出。使用U型封装的LD模块对晶体棒进行侧面泵浦,磷酸钛氧铷（RTP）晶体作为调Q晶体,通过提供调Q高压序列,获得了单个脉冲能量大于550 m J,脉冲宽度小于8 ns,脉冲间隔180~240μs可调的脉冲序列输出,脉冲序列间隔稳定,能量保持一致,激光器重复频率5 Hz。展开更多
基金The National Natural Science Foundation of China, No. 30080016 and No. 30470977
文摘AIM: To search candidate tumor suppressor genes (TSGs) on chromosome 4q through detecting high loss of heterozygosity (LOH) regions in sporadic colorectal carcinoma in Chinese patients. METHODS: Thirteen fluorescent labeled polymorphic microsatellite markers were analyzed in 83 cases of colorectal carcinoma and matched normal tissue DNA by polymerase chain reaction (PCR). PCR products were eletrophoresed on an ABI 377 DNA sequencer. Genescan 3.7 and Genotype 3.7 software were used for LOH scanning and analysis. Comparison between LOH frequency and clinicopathological factors were performed by χ2 test. RESULTS: Data were collected on all informative loci. The average LOH frequency on 4q was 28.56%. The D4S2915 locus showed highest LOH frequency (36.17%). Two obvious deletion regions were detected: one between D4S3000 and D4S2915 locus (4q12-21.1), another flanked by D4S407 and D4S2939 locus (4q25-31.1). None case showed complete deletion of 4q, most cases displayed interstitial deletion pattern solely. Furthermore, compared with clinicopathological features, a significant relationship was observed between LOH frequencies on D4S3018locus. In tumors larger than 5 cm in diameter, LOH frequency was significantly higher than tumors that were less than 5 cm (56% vs 13.79%, P = 0.01). On D4S1534 locus, LOH was significantly associated with liver metastasis (80% vs 17.25%, P = 0.012). No relationship was detected on other locus compared with clinicopathologial features. CONCLUSION: By high resolution deletion mapping, two high frequency regions of LOH (4q12-21.1 and 4q25-31.1) were detected, which may contribute to locate TSGs on chromosome 4q involved in carcinogenesis and progression of sporadic colorectal carcinoma.
文摘The paper deals with the power quality analysis of interlaced four quadrant (4Q) converters with constant switching frequency. These are in fact the input stages of the locomotives and high speed trains supplied by 25 kV, 50 Hz and 15 kV, 16.7 Hz lines. Due to the high power needed for the trains circulation, the 4Q converter can absorb distorted currents, whose harmonic content can affect the signaling systems and communication devices. The presence of more converters gives the opportunity, using dedicated commutation strategy, to interlace them in order to reduce the harmonic content in the absorbed current. In the paper a suitable model of more 4Q converters is developed. The control logic implemented in the model allows the evaluation of the harmonic contribution of both single converter and the interlaced configuration. The analysis is carried out through electromagnetic transient simulations.
文摘License plate recognition system plays an important role in many applications. An automatic recognizer for Iraqi License Plates using ELMAN Neural network is proposed in this manuscript. The processing procedures are developed in several stages. Experimental results are reported in the end of the paper to illustrate the performance of the proposed method.
文摘Adaptive noise data filtering in real-time requires dedicated hardware to meet demanding time requirements. Both DSP processors and FPGAs were studied with respect to their performance in power consumption, hardware architecture, and speed for real time applications. For testing purposes, real time adaptive noise filters have been implemented and simulated on two different platforms, Motorola DSP56303 EVM and Xilinx Spartan III boards. This study has shown that in high speed applications, FPGAs are advantageous over DSPs with respect of their speed and noise reduction because of their parallel architecture. FPGAs can handle more processes at the same time when compared to DSPs, while the later can only handle a limited number of parallel instructions at a time. The speed in both processors impacts the noise reduction in real time. As the DSP core gets slower, the noise removal in real time gets harder to achieve. With respect to power, DSPs are advantageous over FPGAs. FPGAs have reconfigurable gate structure which consumes more power. In case of DSPs, the hardware has been already configured, which requires less power consumption? FPGAs are built for general purposes, and their silicon area in the core is bigger than that of DSPs. This is another factor that affects power consumption. As a result, in high frequency applications, FPGAs are advantageous as compared to DSPs. In low frequency applications, DSPs and FPGAs both satisfy the requirements for noise cancelling. For low frequency applications, DSPs are advantageous in their power consumption and applications for the battery power devices. Software utilizing Matlab, VHDL code run on Xilinix system, and assembly running on Motorola development systems, have been used for the demonstration of this study.
文摘Primary intestinal lymphangiectasia(PIL)is a rare disorder characterized by dilated intestinal lymphatics and the development of protein-losing enteropathy.Patients with PIL develop hypoalbuminemia,hypocalcemia,lymphopenia and hypogammaglobulinemia,and present with bilateral lower limb edema,fatigue,abdominal pain and diarrhea.Endoscopy reveals diffusely elongated,circumferential and polypoid mucosae covered with whitish enlarged villi,all of which indicate intestinal lymphangiectasia.Diagnosis is conf irmed by characteristic tissue pathology,which includes dilated intestinal lymphatics with diffusely swollen mucosa and enlarged villi.The prevalence of PIL has increased since the introduction of capsule endoscopy.The etiology and prevalence of PIL remain unknown.Some studies have reported that several genes and regulatory molecules for lymphangiogenesis are related to PIL.We report the case of a patient with PIL involving the entire small bowel that was confirmed by capsule endoscopy and double-balloon enteroscopy-guided tissue pathology who carried a deletion on chromosome 4q25.The relationship between this deletion on chromosome 4 and PIL remains to be investigated.
文摘将杯[4]醌(Calix[4]quinone,C4Q)通过灌注法与有序介孔炭CMK-3制备成纳米复合材料,可抑制其在常规有机电解液中的溶解。为了进一步提升其电化学性能,本文在C4Q/CMK-3复合材料中加入单壁碳纳米管(SWCNTs),减少了CMK-3的用量,并代替导电炭黑Super-P作为导电剂,通过脱泡搅拌法制备了C4Q/CMK-3/SWCNTs复合材料。研究表明,当m(C4Q)∶m(CMK-3)∶m(SWCNTs)为1∶1∶1时,电化学性能最佳,0. 1 C电流密度下循环100圈后,电池的容量保持为238. 7 m A·h/g,当电流密度增大到1 C时,放电容量仍有260 m A·h/g,这是由于SWCNTs在复合材料C4Q/CMK-3中构建了三维导电网络,增强了电极的稳定性,降低了电池内阻,从而提升了电池的循环性能与倍率性能。
文摘设计了激光二极管侧面泵浦两级放大电光调Q全固态Nd∶YAG激光器,实现间距可调的脉冲序列激光输出。使用U型封装的LD模块对晶体棒进行侧面泵浦,磷酸钛氧铷（RTP）晶体作为调Q晶体,通过提供调Q高压序列,获得了单个脉冲能量大于550 m J,脉冲宽度小于8 ns,脉冲间隔180~240μs可调的脉冲序列输出,脉冲序列间隔稳定,能量保持一致,激光器重复频率5 Hz。
