Poly（3-hydroxybutyrate-co-3-hydroxyhexanoate） （PHBHHx） scaffolds were prepared by thermally inducing phase separation （TIPS） for bone reconstruction. Scanning electron microscopy and porosity measurements were u...Poly（3-hydroxybutyrate-co-3-hydroxyhexanoate） （PHBHHx） scaffolds were prepared by thermally inducing phase separation （TIPS） for bone reconstruction. Scanning electron microscopy and porosity measurements were used to analyze the structure and properties of the scaffolds. The pore diameter of the scaffolds could be easily controlled by changing the quenching temperature and time. The biocompatibility was assessed by examining the proliferation and morphology of MC 3T3-E1 osteoprogenitor cells seeded on the scaffolds. Cultures grown in the presence of a source of phosphate ions showed the formation of a mineralized extracellular matrix. The results indicate that PHBHHx scaffolds prepared using TIPS are a promising candidate for bone reconstruction.展开更多
文摘为提高在体骨骼模型的3D重建精度,对CT扫描方式和利用CT图像重建骨骼模型的方法进行研究,提出一种基于灰度特征搜索匹配点的图像层间插值算法.该算法根据插值点相邻层邻近点的灰度值特征选择参考点;以参考点为依据在另一相邻层图像某区域内搜索与参考点灰度相近并且距离较小的匹配点;利用参考点和匹配点灰度值以及距离关系计算插值点灰度值.对人体9块手骨进行模型重建,将原始CT图像重建模型和插值优化后的重建模型分别与解剖模型进行比较的结果表明,优化前与优化后平均正偏差均值由0.30 mm减小到0.11 mm,平均负偏差均值由0.27 mm减小到0.09 mm.
基金Supported by the National Key Basic Research and Development (973) Program of China (No. 2005CB623905)the Tsinghua-Yue-Yuen Medical Science Fund
文摘Poly（3-hydroxybutyrate-co-3-hydroxyhexanoate） （PHBHHx） scaffolds were prepared by thermally inducing phase separation （TIPS） for bone reconstruction. Scanning electron microscopy and porosity measurements were used to analyze the structure and properties of the scaffolds. The pore diameter of the scaffolds could be easily controlled by changing the quenching temperature and time. The biocompatibility was assessed by examining the proliferation and morphology of MC 3T3-E1 osteoprogenitor cells seeded on the scaffolds. Cultures grown in the presence of a source of phosphate ions showed the formation of a mineralized extracellular matrix. The results indicate that PHBHHx scaffolds prepared using TIPS are a promising candidate for bone reconstruction.
