Synthesis and characterization of 2-amino-6-trifluoromethylpyrimidine derivatives were reported in this paper.Condensation of guanidine hydrochloride with ethy1-4,4,4-triflu oroacetoacetate,in which the yield can reac...Synthesis and characterization of 2-amino-6-trifluoromethylpyrimidine derivatives were reported in this paper.Condensation of guanidine hydrochloride with ethy1-4,4,4-triflu oroacetoacetate,in which the yield can reach 82%,and then chlorination with phosphorus oxychloride resulted in 2-amino-4-chloro-6-trifluoromethylpyrimidine,which,upon reaction with nucleophiles,gave hight yields of the corresponding 2-aminopyrimidines derivatives.Mass spectra show that outgrowth of chlorination is 2-amino-4-（2-amino-6-trifluoromethyl-4-chloro）-6-trifluoromethy1 pyirmidine.The structures were characterized by IR,MS and （）1H NMR spectra.展开更多
A novel potential tridentate Schiff base was prepared by condensing equimolar quantities of 2-hydroxyacetophenone and 2-aminopyrimidine in methanol. This ligand was versatile in forming a series of complexes with lant...A novel potential tridentate Schiff base was prepared by condensing equimolar quantities of 2-hydroxyacetophenone and 2-aminopyrimidine in methanol. This ligand was versatile in forming a series of complexes with lanthanide ions such as La（III）, Pr（III）, Nd（III）, Sm（III）, Gd（III）, Dy（III） and Yb（III）. The ligand and the metal complexes were characterized through elemental analysis, molar conductance, UV-Visible, IR, 1H NMR, and mass spectral studies. The spectral studies indicated that the ligand was coordinated to the metal ion in neutral tridentate fashion through the azomethine nitrogen, one of the nitrogen atoms in the pyrimidine ring and the phenolic oxygen without deprotonation. Thermal decomposition and luminescence property of lanthanum（III） complex were also examined. The X-ray diffraction patterns showed the crystalline nature of the ligand and its lanthanum（III） complex. The DNA cleavage studies of the ligand and the metal complexes were carried out and it was observed that the lanthanum（III） and neo-dymium（III） complexes cleaved the pUC19 DNA effectively. The ligand and the metal complexes were screened for their antibacte-rial activities. The metal complexes were found to be more potent bactericides than the ligand.展开更多
Room temperature ionic liquids were used as a "green" recyclable alternative to conventional solvents in the synthesis of pharmaceutically useful compounds 2-arylimidazo[1, 2-a] pyrimidines through Tschotsch...Room temperature ionic liquids were used as a "green" recyclable alternative to conventional solvents in the synthesis of pharmaceutically useful compounds 2-arylimidazo[1, 2-a] pyrimidines through Tschotschibabin reaction of a-bromoacetophenones with 2-aminopyrimidine in good yields.展开更多
The Cu（Ⅱ）complexes of 2-aminopyrimidine were synthesized and characterized by elemental analyses,TG-DTG.The dissolution enthalpies of the[AP（s）+CuCl2·2H2O（s）]and Cu（AP） Cl2（s）in 100.00 mL 2 mol.L-1HCl ...The Cu（Ⅱ）complexes of 2-aminopyrimidine were synthesized and characterized by elemental analyses,TG-DTG.The dissolution enthalpies of the[AP（s）+CuCl2·2H2O（s）]and Cu（AP） Cl2（s）in 100.00 mL 2 mol.L-1HCl solution were measured at 298.15 K by classical solution calorimetry.The standard molar reaction enthalpy of the coondination reaction of 2-aminopyrimidine with Cu（Ⅱ）has been determined by a thermochemical cycle(ΔrH<sup>○-m=-1.92±0.27kJ·mol-1).From the result,the standard molar enthalpy of formation ΔfH<sup>○-m[Cu（AP）Cl2,s,298.15K] of Cu（AP）Cl2 has been calculated to be-297.46±1.72kJ·mol-1.展开更多
The compound, N-（pyrimidin-2-yl）-N＇-methoxycarbonyl-thiourea, has been synthesized. The single crystal structure has been determined by an X-ray diffractometer. The crystal belongs to triclinic with space group P-1...The compound, N-（pyrimidin-2-yl）-N＇-methoxycarbonyl-thiourea, has been synthesized. The single crystal structure has been determined by an X-ray diffractometer. The crystal belongs to triclinic with space group P-1 and a=0.72152（4） nm, b=0.8056（4） nm, c=0.90772（5） nm, α= 105.141（4）°, β=94.588（4）°, γ= 115.415（4）°, F（000）= 220, the unit cell volume V=0.45704（4） nm^3, the molecule number in one unit cell Z=2, the absorption coefficient μ=0.333 mm^-1, the calculated density Dc= 1.542 g/cm^3. The theoretical investigation of the title compound was carried out with B3LYP/6-311G, HF/6-311G and MP2/6-311G methods, and the atomic charges and natural bond orbital analysis were also discussed.展开更多
The chain [ Cu2I2(PPh3)2(C4H5N3)] has been synthesized and characterized by X-ray crystallography.It crystallizes in the triclinic system,space group P 1,with a=0.9985(2)nm,b=1.0998(2)nm,c=1.5174(2)nm,a=87.89(1),P=76... The chain [ Cu2I2(PPh3)2(C4H5N3)] has been synthesized and characterized by X-ray crystallography.It crystallizes in the triclinic system,space group P 1,with a=0.9985(2)nm,b=1.0998(2)nm,c=1.5174(2)nm,a=87.89(1),P=76.73(l),7=77.77(1),V=1.5849(5)nm3,Z=2,Bc=2.095g/cm3 [Gu2I2(PPh3)2(Crh5N3)] has a dimmer unit [Cu2I2(PPh3)2(C4H5N3)].The two N atoms of the phenyl ring of 2-aminopyrimidine bridge two [CuI(PPh3)]2 units,by which a one-dimensional chain is constructed.The van der Waals force makes the molecules arrange in the three-dimensional space.展开更多
The title complex [Cu（ampym）（bapa）Cl]（ClO4） （C10H22Cl2CuN6O4） was synthesized and characterized by elemental analysis, IR and X-ray single-crystal diffraction. The crystal crystallizes in the orthorhombic syst...The title complex [Cu（ampym）（bapa）Cl]（ClO4） （C10H22Cl2CuN6O4） was synthesized and characterized by elemental analysis, IR and X-ray single-crystal diffraction. The crystal crystallizes in the orthorhombic system, space group Pna21 with a = 11.9904（12）, b = 15.9796（16）, c = 8.9 i 43（9） A^°, V = 1708.0（3）A^°3 Mr = 424.78, Z = 4, F（000） = 876, Dc = 1.652 g/cm^3, T = 293 K,μ =1 .619 mm^-1 and λ=0.71073 A^°. The structure was refined to R = 0.0240 and wR ： 0.0564 for 2905 observed reflections with I 〉 2σ（I）. Flack = 0.039（12）.展开更多
文摘Synthesis and characterization of 2-amino-6-trifluoromethylpyrimidine derivatives were reported in this paper.Condensation of guanidine hydrochloride with ethy1-4,4,4-triflu oroacetoacetate,in which the yield can reach 82%,and then chlorination with phosphorus oxychloride resulted in 2-amino-4-chloro-6-trifluoromethylpyrimidine,which,upon reaction with nucleophiles,gave hight yields of the corresponding 2-aminopyrimidines derivatives.Mass spectra show that outgrowth of chlorination is 2-amino-4-（2-amino-6-trifluoromethyl-4-chloro）-6-trifluoromethy1 pyirmidine.The structures were characterized by IR,MS and （）1H NMR spectra.
文摘A novel potential tridentate Schiff base was prepared by condensing equimolar quantities of 2-hydroxyacetophenone and 2-aminopyrimidine in methanol. This ligand was versatile in forming a series of complexes with lanthanide ions such as La（III）, Pr（III）, Nd（III）, Sm（III）, Gd（III）, Dy（III） and Yb（III）. The ligand and the metal complexes were characterized through elemental analysis, molar conductance, UV-Visible, IR, 1H NMR, and mass spectral studies. The spectral studies indicated that the ligand was coordinated to the metal ion in neutral tridentate fashion through the azomethine nitrogen, one of the nitrogen atoms in the pyrimidine ring and the phenolic oxygen without deprotonation. Thermal decomposition and luminescence property of lanthanum（III） complex were also examined. The X-ray diffraction patterns showed the crystalline nature of the ligand and its lanthanum（III） complex. The DNA cleavage studies of the ligand and the metal complexes were carried out and it was observed that the lanthanum（III） and neo-dymium（III） complexes cleaved the pUC19 DNA effectively. The ligand and the metal complexes were screened for their antibacte-rial activities. The metal complexes were found to be more potent bactericides than the ligand.
文摘Room temperature ionic liquids were used as a "green" recyclable alternative to conventional solvents in the synthesis of pharmaceutically useful compounds 2-arylimidazo[1, 2-a] pyrimidines through Tschotschibabin reaction of a-bromoacetophenones with 2-aminopyrimidine in good yields.
文摘The Cu（Ⅱ）complexes of 2-aminopyrimidine were synthesized and characterized by elemental analyses,TG-DTG.The dissolution enthalpies of the[AP（s）+CuCl2·2H2O（s）]and Cu（AP） Cl2（s）in 100.00 mL 2 mol.L-1HCl solution were measured at 298.15 K by classical solution calorimetry.The standard molar reaction enthalpy of the coondination reaction of 2-aminopyrimidine with Cu（Ⅱ）has been determined by a thermochemical cycle(ΔrH<sup>○-m=-1.92±0.27kJ·mol-1).From the result,the standard molar enthalpy of formation ΔfH<sup>○-m[Cu（AP）Cl2,s,298.15K] of Cu（AP）Cl2 has been calculated to be-297.46±1.72kJ·mol-1.
基金Project supported by the National Natural Science Foundation of China （No. 20571060） and Education Committee of Shaanxi Province （No. 05JK294）.
文摘The compound, N-（pyrimidin-2-yl）-N＇-methoxycarbonyl-thiourea, has been synthesized. The single crystal structure has been determined by an X-ray diffractometer. The crystal belongs to triclinic with space group P-1 and a=0.72152（4） nm, b=0.8056（4） nm, c=0.90772（5） nm, α= 105.141（4）°, β=94.588（4）°, γ= 115.415（4）°, F（000）= 220, the unit cell volume V=0.45704（4） nm^3, the molecule number in one unit cell Z=2, the absorption coefficient μ=0.333 mm^-1, the calculated density Dc= 1.542 g/cm^3. The theoretical investigation of the title compound was carried out with B3LYP/6-311G, HF/6-311G and MP2/6-311G methods, and the atomic charges and natural bond orbital analysis were also discussed.
基金Project (No. 952871800) supported by Beijing Talent Found for Young Sci-Tech Researchers
文摘 The chain [ Cu2I2(PPh3)2(C4H5N3)] has been synthesized and characterized by X-ray crystallography.It crystallizes in the triclinic system,space group P 1,with a=0.9985(2)nm,b=1.0998(2)nm,c=1.5174(2)nm,a=87.89(1),P=76.73(l),7=77.77(1),V=1.5849(5)nm3,Z=2,Bc=2.095g/cm3 [Gu2I2(PPh3)2(Crh5N3)] has a dimmer unit [Cu2I2(PPh3)2(C4H5N3)].The two N atoms of the phenyl ring of 2-aminopyrimidine bridge two [CuI(PPh3)]2 units,by which a one-dimensional chain is constructed.The van der Waals force makes the molecules arrange in the three-dimensional space.
基金This project was supported by the Foundation of Science Committee of Jiangsu province (BK2005045)
文摘The title complex [Cu（ampym）（bapa）Cl]（ClO4） （C10H22Cl2CuN6O4） was synthesized and characterized by elemental analysis, IR and X-ray single-crystal diffraction. The crystal crystallizes in the orthorhombic system, space group Pna21 with a = 11.9904（12）, b = 15.9796（16）, c = 8.9 i 43（9） A^°, V = 1708.0（3）A^°3 Mr = 424.78, Z = 4, F（000） = 876, Dc = 1.652 g/cm^3, T = 293 K,μ =1 .619 mm^-1 and λ=0.71073 A^°. The structure was refined to R = 0.0240 and wR ： 0.0564 for 2905 observed reflections with I 〉 2σ（I）. Flack = 0.039（12）.
