The herbal medicine Tong Luo Jiu Nao （TLJN） contains geniposide （GP） and ginsenoside Rgl at a molar ratio of i0：1. Rgl is the major component of another herbal medicine, panax notoginseng saponin （PNS）. TLJN ha...The herbal medicine Tong Luo Jiu Nao （TLJN） contains geniposide （GP） and ginsenoside Rgl at a molar ratio of i0：1. Rgl is the major component of another herbal medicine, panax notoginseng saponin （PNS）. TLJN has been shown to strengthen brain function in humans, and in animals it improves learning and memory. We have previously shown that TLJN reduces amyloi- dogenic processing in Alzheimer＇s disease （AD） mouse models. Together this suggests TLJN may be a potential treatment for patients with dementia. Because chronic damage of the central nervous system by formaldehyde （FA） has been presented as a risk factor for age-associated cognitive dysfunction, in the present study we investigated the protective effect of both TLJN and GP in neuron-like cells exposed to FA. FA-exposed murine N2a neuroblastoma cells were incubated with TLJN, its main in- gredient GP, as well as PNS, to measure cell viability and morphology, the rate of apoptosis and expression of genes encoding Akt, FOXO3, Bcl2 and p53. The CCK-8 assay, cytoskeletal staining and flow cytometry were used to test cell viability, mor- phology and apoptosis, respectively. Fluorescent quantitative real-time PCR （qRT-PCR） was used to monitor changes in gene expression, and HPLC to determine the rate of FA clearance. Treatment of N2a cells with 0.09 mmol L-1 FA for 24 h signifi- cantly reduced cell viability, changed cell morphology and promoted apoptosis. Both TLJN and GP conferred neuroprotection to FA-treated N2a cells, whereas PNS, which had to be used at lower concentrations because of its toxicity, did not. Our data demonstrate that TLJN can rescue neuronal damage caused by FA and that its main ingredient, GP, has a major role in this ef- ficacy. This presents purified GP as a drug or lead compound for the treatment of AD.展开更多
The acupuncture treatment with Zi Wu Dao Jiu needling was used to treat thepostpartum retention of urine and produced a therapeutic effect better than that of urethral catheteri-zation. The remarkable effectiveness ra...The acupuncture treatment with Zi Wu Dao Jiu needling was used to treat thepostpartum retention of urine and produced a therapeutic effect better than that of urethral catheteri-zation. The remarkable effectiveness rate in patients with a clinical course less than 4 days was 99％.The acupuncture at Huiyang (BL 35) point might stimulate pudendal nerve and relax muscles of uri-nary bladder and urethra to facilitate the discharge of urine.展开更多
Li Po’s poems have been translated and disseminated internationally for hundreds of years.His poems about“jiu”have attracted many Western readers’attention after translation and introduction.Based on Li Po’s poem...Li Po’s poems have been translated and disseminated internationally for hundreds of years.His poems about“jiu”have attracted many Western readers’attention after translation and introduction.Based on Li Po’s poems,this paper proves the fact that Li Po’s Jiu poems play an important role in the international communication of Chinese Jiu culture.With Chinese culture’s“going out”,translators should translate the types of Chinese Jiu and drinking vessels as well as the drinking customs more accurately,so as to make western readers realize the significance of Li Po’s Jiu poems for understanding Chinese Jiu culture.展开更多
基金supported by the National Basic Research Program of China(2012CB911004,2010CB912303)Queensland-Chinese Academy of Sciences Biotechnology Fund(GJHZ1131,GJHZ201302)
文摘The herbal medicine Tong Luo Jiu Nao （TLJN） contains geniposide （GP） and ginsenoside Rgl at a molar ratio of i0：1. Rgl is the major component of another herbal medicine, panax notoginseng saponin （PNS）. TLJN has been shown to strengthen brain function in humans, and in animals it improves learning and memory. We have previously shown that TLJN reduces amyloi- dogenic processing in Alzheimer＇s disease （AD） mouse models. Together this suggests TLJN may be a potential treatment for patients with dementia. Because chronic damage of the central nervous system by formaldehyde （FA） has been presented as a risk factor for age-associated cognitive dysfunction, in the present study we investigated the protective effect of both TLJN and GP in neuron-like cells exposed to FA. FA-exposed murine N2a neuroblastoma cells were incubated with TLJN, its main in- gredient GP, as well as PNS, to measure cell viability and morphology, the rate of apoptosis and expression of genes encoding Akt, FOXO3, Bcl2 and p53. The CCK-8 assay, cytoskeletal staining and flow cytometry were used to test cell viability, mor- phology and apoptosis, respectively. Fluorescent quantitative real-time PCR （qRT-PCR） was used to monitor changes in gene expression, and HPLC to determine the rate of FA clearance. Treatment of N2a cells with 0.09 mmol L-1 FA for 24 h signifi- cantly reduced cell viability, changed cell morphology and promoted apoptosis. Both TLJN and GP conferred neuroprotection to FA-treated N2a cells, whereas PNS, which had to be used at lower concentrations because of its toxicity, did not. Our data demonstrate that TLJN can rescue neuronal damage caused by FA and that its main ingredient, GP, has a major role in this ef- ficacy. This presents purified GP as a drug or lead compound for the treatment of AD.
文摘The acupuncture treatment with Zi Wu Dao Jiu needling was used to treat thepostpartum retention of urine and produced a therapeutic effect better than that of urethral catheteri-zation. The remarkable effectiveness rate in patients with a clinical course less than 4 days was 99％.The acupuncture at Huiyang (BL 35) point might stimulate pudendal nerve and relax muscles of uri-nary bladder and urethra to facilitate the discharge of urine.
基金This essay is an achievement of the project“The International Dissemination of Chinese Jiu Culture Based on Li Po and Du Fu’s Poems”(CJCB2019-05)funded by Research Center for International Transmission of Sichuan Liquor Culture“Ideological and Political Education in English and American Literature Courses”(BKJX2019073)supported by Chengdu University of Information Technology.
文摘Li Po’s poems have been translated and disseminated internationally for hundreds of years.His poems about“jiu”have attracted many Western readers’attention after translation and introduction.Based on Li Po’s poems,this paper proves the fact that Li Po’s Jiu poems play an important role in the international communication of Chinese Jiu culture.With Chinese culture’s“going out”,translators should translate the types of Chinese Jiu and drinking vessels as well as the drinking customs more accurately,so as to make western readers realize the significance of Li Po’s Jiu poems for understanding Chinese Jiu culture.
